Matches in DBpedia 2015-04 for { <http://dbpedia.org/resource/NEDD4L> ?p ?o }
- NEDD4L abstract "Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 (NEDD4-2) is an enzyme (ubiquitin ligase) of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.NEDD4-2 has been shown to ubiquitinate and therefore down regulate the epithelial sodium channel (ENaC) in the collecting ducts of the kidneys, therefore opposing the actions of aldosterone and increasing salt excretion. In Liddle's Syndrome NEDD4 is unable to bind to the ENaC and lead to salt retention and hypertension occur.NEDD4L belongs to the NEDD4 family of E3 HECT domain ubiquitin ligases. It is the closest homologue of NEDD4, the prototypic member of the family and probably arose as a result of gene duplication. While NEDD4 orthologues are present in all eukaryotes, NEDD4L proteins are limited to vertebrates. NEDD4L proteins are known to be involved in regulating many membrane proteins via ubiquitination and endocytosis.NEDD4L protein is expressed widely. The primary targets of NEDD4-2 include the epithelial sodium channel (ENaC), the Na+-Cl- co-transporter (NCC), and the voltage gated sodium channels (Navs), although additional targets are predicted from in vitro studies. NEDD4-2 gene in mice is essential for animal survival and the polymorphisms in NEDD4L are associated with human hypertension.".
- NEDD4L entrezgene "23327".
- NEDD4L wikiPageID "14157274".
- NEDD4L wikiPageRevisionID "644435875".
- NEDD4L doi "10.1007".
- NEDD4L doi "10.1016".
- NEDD4L doi "10.1038".
- NEDD4L doi "10.1046".
- NEDD4L doi "10.1073".
- NEDD4L doi "10.1074".
- NEDD4L doi "10.1093".
- NEDD4L doi "10.1128".
- NEDD4L doi "10.1152".
- NEDD4L doi "10.1385".
- NEDD4L hasPhotoCollection NEDD4L.
- NEDD4L issue "1".
- NEDD4L issue "11".
- NEDD4L issue "12".
- NEDD4L issue "2".
- NEDD4L issue "20".
- NEDD4L issue "22".
- NEDD4L issue "24".
- NEDD4L issue "33".
- NEDD4L issue "5".
- NEDD4L issue "7".
- NEDD4L journal "Am. J. Physiol. Renal Physiol.".
- NEDD4L journal "Biochim. Biophys. Acta".
- NEDD4L journal "C. R. Biol.".
- NEDD4L journal "Cell Biochem. Biophys.".
- NEDD4L journal "DNA Res.".
- NEDD4L journal "EMBO J.".
- NEDD4L journal "Eur. J. Hum. Genet.".
- NEDD4L journal "J. Biol. Chem.".
- NEDD4L journal "J. Hum. Genet.".
- NEDD4L journal "J. Neurochem.".
- NEDD4L journal "Mol. Cell. Biol.".
- NEDD4L journal "Mol. Cell. Endocrinol.".
- NEDD4L journal "Proc. Natl. Acad. Sci. U.S.A.".
- NEDD4L pages "105".
- NEDD4L pages "11199".
- NEDD4L pages "1181".
- NEDD4L pages "2795".
- NEDD4L pages "29406".
- NEDD4L pages "307".
- NEDD4L pages "5".
- NEDD4L pages "51".
- NEDD4L pages "59".
- NEDD4L pages "615".
- NEDD4L pages "665".
- NEDD4L pages "7052".
- NEDD4L pages "8526".
- NEDD4L pages "922".
- NEDD4L pages "9307".
- NEDD4L pages "F916-29".
- NEDD4L pmc "102158".
- NEDD4L pmc "125341".
- NEDD4L pmc "58707".
- NEDD4L pmid "11046148".
- NEDD4L pmid "11562473".
- NEDD4L pmid "11696533".
- NEDD4L pmid "11742982".
- NEDD4L pmid "11748237".
- NEDD4L pmid "11840194".
- NEDD4L pmid "12050153".
- NEDD4L pmid "12139396".
- NEDD4L pmid "12522688".
- NEDD4L pmid "12729930".
- NEDD4L pmid "12876068".
- NEDD4L pmid "12911626".
- NEDD4L pmid "14556380".
- NEDD4L pmid "14615060".
- NEDD4L pmid "8576257".
- NEDD4L pmid "9455477".
- NEDD4L title "Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains".
- NEDD4L title "Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells".
- NEDD4L title "Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance".
- NEDD4L title "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 and characterization of their interaction with E6-AP and RSP5".
- NEDD4L title "Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript".
- NEDD4L title "Identification of new partners of the epithelial sodium channel alpha subunit".
- NEDD4L title "Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases".
- NEDD4L title "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein".
- NEDD4L title "NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene".
- NEDD4L title "Patch-clamp studies on epithelial sodium channels in salivary duct cells".
- NEDD4L title "Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na channel cell surface expression".
- NEDD4L title "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro".
- NEDD4L title "Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells".
- NEDD4L title "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein".
- NEDD4L title "Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B".
- NEDD4L title "Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel".
- NEDD4L vauthors "Asher C, Sinha I, Garty H".
- NEDD4L vauthors "Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F".
- NEDD4L vauthors "Chen H, Ross CA, Wang N, Huo Y, MacKinnon DF, Potash JB, Simpson SG, McMahon FJ, DePaulo Jr JR, McInnis MG".
- NEDD4L vauthors "Cook DI, Dinudom A, Komwatana P, Kumar S, Young JA".
- NEDD4L vauthors "Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O".
- NEDD4L vauthors "Dunn DM, Ishigami T, Pankow J, von Niederhausern A, Alder J, Hunt SC, Leppert MF, Lalouel JM, Weiss RB".
- NEDD4L vauthors "Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S".
- NEDD4L vauthors "Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O".
- NEDD4L vauthors "Itani OA, Campbell JR, Herrero J, Snyder PM, Thomas CP".
- NEDD4L vauthors "Kikonyogo A, Bouamr F, Vana ML, Xiang Y, Aiyar A, Carter C, Leis J".
- NEDD4L vauthors "Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S".