Matches in DBpedia 2015-04 for { <http://dbpedia.org/resource/GPNMB> ?p ?o }
- GPNMB abstract "Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.".
- GPNMB entrezgene "10457".
- GPNMB wikiPageExternalLink pmidlookup?view=long&pmid=12176896.
- GPNMB wikiPageExternalLink pmidlookup?view=long&pmid=9847074.
- GPNMB wikiPageExternalLink abstract.php?id=1468.
- GPNMB wikiPageID "14794357".
- GPNMB wikiPageRevisionID "641692427".
- GPNMB authorSeparator ",".
- GPNMB bibcode "2005".
- GPNMB date "April 2005".
- GPNMB date "April 2006".
- GPNMB date "December 2005".
- GPNMB date "February 2005".
- GPNMB date "July 2004".
- GPNMB date "March 2003".
- GPNMB date "November 1998".
- GPNMB date "November 2005".
- GPNMB date "November 2006".
- GPNMB date "October 2002".
- GPNMB date "October 2003".
- GPNMB date "October 2005".
- GPNMB date "October 2007".
- GPNMB date "September 2002".
- GPNMB doi "10.1007".
- GPNMB doi "10.1016".
- GPNMB doi "10.1021".
- GPNMB doi "10.1038".
- GPNMB doi "10.1073".
- GPNMB doi "10.1101".
- GPNMB doi "10.1158".
- GPNMB doi "10.4161".
- GPNMB doiBrokendate "2015-01-09".
- GPNMB first "Center".
- GPNMB hasPhotoCollection GPNMB.
- GPNMB issue "1".
- GPNMB issue "10".
- GPNMB issue "11".
- GPNMB issue "12".
- GPNMB issue "2".
- GPNMB issue "3".
- GPNMB issue "4".
- GPNMB issue "44".
- GPNMB issue "5".
- GPNMB issue "7".
- GPNMB issue "7062".
- GPNMB journal "Blood".
- GPNMB journal "Brain Research. Gene Expression Patterns".
- GPNMB journal "Cell Cycle".
- GPNMB journal "Clinical Cancer Research".
- GPNMB journal "Critical Reviews in Eukaryotic Gene Expression".
- GPNMB journal "Genome Research".
- GPNMB journal "Journal of Hepatology".
- GPNMB journal "Journal of Proteome Research".
- GPNMB journal "Mammalian Genome".
- GPNMB journal "Molecular Cancer Research".
- GPNMB journal "Nature".
- GPNMB journal "Proceedings of the National Academy of Sciences of the United States of America".
- GPNMB journal "Regulatory Peptides".
- GPNMB last "Armbrust".
- GPNMB last "Fernandes".
- GPNMB last "Genome Sequencing".
- GPNMB last "Gross".
- GPNMB last "Pepin".
- GPNMB last "Ramadori".
- GPNMB last "Russo".
- GPNMB last "Schröder".
- GPNMB last "Yehia".
- GPNMB pages "1001".
- GPNMB pages "1097".
- GPNMB pages "1173".
- GPNMB pages "1324".
- GPNMB pages "159".
- GPNMB pages "16013".
- GPNMB pages "169".
- GPNMB pages "1742".
- GPNMB pages "1970".
- GPNMB pages "205".
- GPNMB pages "2265".
- GPNMB pages "3135".
- GPNMB pages "315".
- GPNMB pages "565".
- GPNMB pages "69".
- GPNMB pages "942".
- GPNMB pmc "1266037".
- GPNMB pmc "403697".
- GPNMB pmc "442148".
- GPNMB pmid "12176896".
- GPNMB pmid "12609765".
- GPNMB pmid "12638126".
- GPNMB pmid "12643545".
- GPNMB pmid "12975309".
- GPNMB pmid "14696968".
- GPNMB pmid "15231748".
- GPNMB pmid "15684612".
- GPNMB pmid "15763343".
- GPNMB pmid "16189514".
- GPNMB pmid "16247014".
- GPNMB pmid "16341674".
- GPNMB pmid "16609006".
- GPNMB pmid "17081065".