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Deleted_in_Colorectal_Cancer abstract "Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.".
Deleted_in_Colorectal_Cancer entrezgene "1630".
Deleted_in_Colorectal_Cancer wikiPageExternalLink default.htm.
Deleted_in_Colorectal_Cancer wikiPageExternalLink 3.htm.
Deleted_in_Colorectal_Cancer wikiPageExternalLink show_pathway?hsa04360+1630.
Deleted_in_Colorectal_Cancer wikiPageExternalLink show_pathway?hsa05210+1630.
Deleted_in_Colorectal_Cancer wikiPageExternalLink index.cfm?pagename=brainBriefings_axonGuidance.
Deleted_in_Colorectal_Cancer wikiPageID "6802179".
Deleted_in_Colorectal_Cancer wikiPageRevisionID "642297578".
Deleted_in_Colorectal_Cancer date "January 1996".
Deleted_in_Colorectal_Cancer doi "10.1002".
Deleted_in_Colorectal_Cancer doi "10.1006".
Deleted_in_Colorectal_Cancer doi "10.1007".
Deleted_in_Colorectal_Cancer doi "10.1016".
Deleted_in_Colorectal_Cancer doi "10.1038".
Deleted_in_Colorectal_Cancer doi "10.1073".
Deleted_in_Colorectal_Cancer doi "10.1101".
Deleted_in_Colorectal_Cancer doi "10.1126".
Deleted_in_Colorectal_Cancer hasPhotoCollection Deleted_in_Colorectal_Cancer.
Deleted_in_Colorectal_Cancer issue "1".
Deleted_in_Colorectal_Cancer issue "10".
Deleted_in_Colorectal_Cancer issue "11".
Deleted_in_Colorectal_Cancer issue "12".
Deleted_in_Colorectal_Cancer issue "16".
Deleted_in_Colorectal_Cancer issue "2".
Deleted_in_Colorectal_Cancer issue "20".
Deleted_in_Colorectal_Cancer issue "3".
Deleted_in_Colorectal_Cancer issue "4".
Deleted_in_Colorectal_Cancer issue "4938".
Deleted_in_Colorectal_Cancer issue "6".
Deleted_in_Colorectal_Cancer issue "6704".
Deleted_in_Colorectal_Cancer issue "6805".
Deleted_in_Colorectal_Cancer journal "Cancer Res.".
Deleted_in_Colorectal_Cancer journal "Cell Growth Differ.".
Deleted_in_Colorectal_Cancer journal "Cell".
Deleted_in_Colorectal_Cancer journal "Cold Spring Harb Symp Quant Biol.".
Deleted_in_Colorectal_Cancer journal "Gan to Kagaku Ryoho".
Deleted_in_Colorectal_Cancer journal "Genes Chromosomes Cancer".
Deleted_in_Colorectal_Cancer journal "Genes Dev.".
Deleted_in_Colorectal_Cancer journal "Genomics".
Deleted_in_Colorectal_Cancer journal "J Mol Med.".
Deleted_in_Colorectal_Cancer journal "J Pathol.".
Deleted_in_Colorectal_Cancer journal "Mol. Cell. Biol.".
Deleted_in_Colorectal_Cancer journal "Nature Reviews Cancer".
Deleted_in_Colorectal_Cancer journal "Nature".
Deleted_in_Colorectal_Cancer journal "Proc Natl Acad Sci USA.".
Deleted_in_Colorectal_Cancer journal "Science".
Deleted_in_Colorectal_Cancer pages "1174".
Deleted_in_Colorectal_Cancer pages "175".
Deleted_in_Colorectal_Cancer pages "249".
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Deleted_in_Colorectal_Cancer pmc "316613".
Deleted_in_Colorectal_Cancer pmc "83929".
Deleted_in_Colorectal_Cancer pmid "10719364".
Deleted_in_Colorectal_Cancer pmid "11048721".
Deleted_in_Colorectal_Cancer pmid "11248093".
Deleted_in_Colorectal_Cancer pmid "15573119".
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Deleted_in_Colorectal_Cancer pmid "2294591".
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Deleted_in_Colorectal_Cancer pmid "8109990".
Deleted_in_Colorectal_Cancer pmid "8187090".
Deleted_in_Colorectal_Cancer pmid "8188295".
Deleted_in_Colorectal_Cancer pmid "8834768".
Deleted_in_Colorectal_Cancer pmid "8861902".
Deleted_in_Colorectal_Cancer pmid "9334332".
Deleted_in_Colorectal_Cancer pmid "9796814".
Deleted_in_Colorectal_Cancer pmid "9858595".
Deleted_in_Colorectal_Cancer pmid "9950216".
Deleted_in_Colorectal_Cancer title "Deleted in Colorectal Cancer encodes a netrin receptor.".
Deleted_in_Colorectal_Cancer title "Expression and alternative splicing of the deleted in colorectal cancer gene in normal and malignant tissues.".
Deleted_in_Colorectal_Cancer title "Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.".
Deleted_in_Colorectal_Cancer title "Identification of a chromosome 18q gene that is altered in colorectal cancers.".
Deleted_in_Colorectal_Cancer title "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.".
Deleted_in_Colorectal_Cancer title "Netrin-1 and its receptors in tumorigenesis.".
Deleted_in_Colorectal_Cancer title "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.".
Deleted_in_Colorectal_Cancer title "Netrin-1: interaction with deleted in colorectal cancer and alterations in brain tumors and neuroblastomas.".
Deleted_in_Colorectal_Cancer title "Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors.".
Deleted_in_Colorectal_Cancer title "Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.".
Deleted_in_Colorectal_Cancer title "Scrambled exons.".
Deleted_in_Colorectal_Cancer title "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.".
Deleted_in_Colorectal_Cancer title "Studies of the deleted in colorectal cancer gene in normal and neoplastic tissues.".