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- Zona_glomerulosa abstract "The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule. Its cells are ovoid and arranged in clusters or arches (glomus is Latin for "ball").In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. Although sustained production of aldosterone requires persistent calcium entry through low-voltage activated Ca2+ channels, isolated zona glomerulosa cells are considered nonexcitable, with recorded membrane voltages that are too hyperpolarized to permit Ca2+ channels entry. However, mouse zona glomerulosa cells within adrenal slices spontaneously generate membrane potential oscillations of low periodicity; this innate electrical excitability of zona glomerulosa cells provides a platform for the production of a recurrent Ca2+ channels signal that can be controlled by angiotensin II and extracellular potassium, the 2 major regulators of aldosterone production. Aldosterone regulates the body's concentration of electrolytes, primarily sodium and potassium, by acting on the distal convoluted tubule of kidney nephrons to: increase sodium reabsorption, increase potassium excretion, increase water reabsorption through osmosis.The enzyme aldosterone synthase (also known as CYP11B2) acts in this location The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues has been predicted and reported by several authors and it was suggested that the expression of proteins like the neuronal cell adhesion molecule (NCAM) in the cells of the zona glomerulosa reflects the regenerative feature of these cells, which would lose NCAM immunoreactivity after moving to the zona fasciculata. However, together with other data on neuroendocrine properties of zona glomerulosa cells, NCAM expression may reflect a neuroendocrine differentiation of these cells. Voltage-dependent calcium channels have been detected in the zona glomerulosa of the human adrenal, which suggests that calcium-channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo.".
- Zona_glomerulosa dorlandsPrefix "z_01".
- Zona_glomerulosa dorlandsSuffix "12869730".
- Zona_glomerulosa grayPage "1278".
- Zona_glomerulosa graySubject "277".
- Zona_glomerulosa thumbnail Gray1185.png?width=300.
- Zona_glomerulosa wikiPageID "2648999".
- Zona_glomerulosa wikiPageLength "7888".
- Zona_glomerulosa wikiPageOutDegree "31".
- Zona_glomerulosa wikiPageRevisionID "656324563".
- Zona_glomerulosa wikiPageWikiLink Adrenal_cortex.
- Zona_glomerulosa wikiPageWikiLink Adrenal_gland.
- Zona_glomerulosa wikiPageWikiLink Aldosterone.
- Zona_glomerulosa wikiPageWikiLink Aldosterone_synthase.
- Zona_glomerulosa wikiPageWikiLink Angiotensin.
- Zona_glomerulosa wikiPageWikiLink Angiotensin_II.
- Zona_glomerulosa wikiPageWikiLink Calcium.
- Zona_glomerulosa wikiPageWikiLink Calcium-channel_blocker.
- Zona_glomerulosa wikiPageWikiLink Calcium_channel.
- Zona_glomerulosa wikiPageWikiLink Calcium_channel_blocker.
- Zona_glomerulosa wikiPageWikiLink Category:Adrenal_gland.
- Zona_glomerulosa wikiPageWikiLink Distal_convoluted_tubule.
- Zona_glomerulosa wikiPageWikiLink Electrolyte.
- Zona_glomerulosa wikiPageWikiLink Excretion.
- Zona_glomerulosa wikiPageWikiLink Kidney.
- Zona_glomerulosa wikiPageWikiLink Latin.
- Zona_glomerulosa wikiPageWikiLink Latin_language.
- Zona_glomerulosa wikiPageWikiLink Mineralocorticoid.
- Zona_glomerulosa wikiPageWikiLink Nephron.
- Zona_glomerulosa wikiPageWikiLink Neural_cell_adhesion_molecule.
- Zona_glomerulosa wikiPageWikiLink Neuronal_cell_adhesion_molecule.
- Zona_glomerulosa wikiPageWikiLink Osmosis.
- Zona_glomerulosa wikiPageWikiLink Potassium.
- Zona_glomerulosa wikiPageWikiLink Renal_capsule.
- Zona_glomerulosa wikiPageWikiLink Renal_circulation.
- Zona_glomerulosa wikiPageWikiLink Renin.
- Zona_glomerulosa wikiPageWikiLink Renin-angiotensin_system.
- Zona_glomerulosa wikiPageWikiLink Renin–angiotensin_system.
- Zona_glomerulosa wikiPageWikiLink Sodium.
- Zona_glomerulosa wikiPageWikiLink Voltage-dependent_calcium_channel.
- Zona_glomerulosa wikiPageWikiLink Zona_fasciculata.
- Zona_glomerulosa wikiPageWikiLink File:Adrenal_gland_(zona_glomerulosa).JPG.
- Zona_glomerulosa wikiPageWikiLinkText "Zona glomerulosa".
- Zona_glomerulosa wikiPageWikiLinkText "cells".
- Zona_glomerulosa wikiPageWikiLinkText "zona glomerulosa".
- Zona_glomerulosa caption "Layers of cortex.".
- Zona_glomerulosa dorlandspre "z_01".
- Zona_glomerulosa dorlandssuf "12869730".
- Zona_glomerulosa graypage "1278".
- Zona_glomerulosa graysubject "277".
- Zona_glomerulosa hasPhotoCollection Zona_glomerulosa.
- Zona_glomerulosa latin "Zona glomerulosa".
- Zona_glomerulosa name "Zona glomerulosa".
- Zona_glomerulosa wikiPageUsesTemplate Template:Adrenal_gland.
- Zona_glomerulosa wikiPageUsesTemplate Template:AnatomyAtlasesMicroscopic.
- Zona_glomerulosa wikiPageUsesTemplate Template:BUHistology.
- Zona_glomerulosa wikiPageUsesTemplate Template:Infobox_anatomy.
- Zona_glomerulosa wikiPageUsesTemplate Template:Reflist.
- Zona_glomerulosa subject Category:Adrenal_gland.
- Zona_glomerulosa type AnatomicalStructure.
- Zona_glomerulosa type Article.
- Zona_glomerulosa type Article.
- Zona_glomerulosa type Thing.
- Zona_glomerulosa type Q4936952.
- Zona_glomerulosa comment "The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule. Its cells are ovoid and arranged in clusters or arches (glomus is Latin for "ball").In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system.".
- Zona_glomerulosa label "Zona glomerulosa".
- Zona_glomerulosa sameAs Zona_glomerular.
- Zona_glomerulosa sameAs Zona_glomerulosa.
- Zona_glomerulosa sameAs m.02p6rxb.
- Zona_glomerulosa sameAs Zona_glomerulosa.
- Zona_glomerulosa sameAs Q3551060.
- Zona_glomerulosa sameAs Q3551060.
- Zona_glomerulosa wasDerivedFrom Zona_glomerulosa?oldid=656324563.
- Zona_glomerulosa depiction Gray1185.png.
- Zona_glomerulosa isPrimaryTopicOf Zona_glomerulosa.
- Zona_glomerulosa name "Zona glomerulosa".