Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Weinreb_ketone_synthesis> ?p ?o }
- Weinreb_ketone_synthesis abstract "The Weinreb–Nahm ketone synthesis is a chemical reaction used in organic chemistry to make carbon–carbon bonds. It was discovered in 1981 by Steven M. Weinreb and Steven Nahm as a method to synthesize ketones. The original reaction involved two subsequent nucleophilic acyl substitutions: the conversion of an acid chloride into an N,O-dimethylhydroxyamide, known as a Weinreb–Nahm amide, and subsequent treatment of this species with an organometallic reagent such as a Grignard reagent or organolithium reagent. Nahm and Weinreb also reported the synthesis of aldehydes by reduction of the amide with an excess of lithium aluminum hydride (see amide reduction).The major advantage of this method over addition of organometallic reagents to more typical acyl compounds is that it avoids the common problem of over-addition. For these latter reactions, two equivalents of the incoming group add to form an alcohol rather than a ketone or aldehyde. This occurs even if the equivalents of nucleophile are closely controlled. The Weinreb–Nahm amide has since been adopted into regular use by organic chemists as a dependable method for the synthesis of ketones. These functional groups are present in a large number of natural products and can be reliably reacted to form new carbon–carbon bonds or converted into other functional groups. This method has been used in a number of syntheses, including Macrosphelides A and B, Amphidinolide J, and Spirofungins A and B. (See Scope below)".
- Weinreb_ketone_synthesis thumbnail WeinrebAmideIntro.png?width=300.
- Weinreb_ketone_synthesis wikiPageID "3325084".
- Weinreb_ketone_synthesis wikiPageLength "11208".
- Weinreb_ketone_synthesis wikiPageOutDegree "73".
- Weinreb_ketone_synthesis wikiPageRevisionID "667069199".
- Weinreb_ketone_synthesis wikiPageWikiLink Acid_chloride.
- Weinreb_ketone_synthesis wikiPageWikiLink Acyl.
- Weinreb_ketone_synthesis wikiPageWikiLink Acyl_chloride.
- Weinreb_ketone_synthesis wikiPageWikiLink Alcohol.
- Weinreb_ketone_synthesis wikiPageWikiLink Aldehyde.
- Weinreb_ketone_synthesis wikiPageWikiLink Aliphatic.
- Weinreb_ketone_synthesis wikiPageWikiLink Aliphatic_compound.
- Weinreb_ketone_synthesis wikiPageWikiLink Alkene.
- Weinreb_ketone_synthesis wikiPageWikiLink Alkyne.
- Weinreb_ketone_synthesis wikiPageWikiLink Amide.
- Weinreb_ketone_synthesis wikiPageWikiLink Amide_reduction.
- Weinreb_ketone_synthesis wikiPageWikiLink Amino_acid.
- Weinreb_ketone_synthesis wikiPageWikiLink Amino_acids.
- Weinreb_ketone_synthesis wikiPageWikiLink Antibiotic.
- Weinreb_ketone_synthesis wikiPageWikiLink Antibiotics.
- Weinreb_ketone_synthesis wikiPageWikiLink Aryl.
- Weinreb_ketone_synthesis wikiPageWikiLink Carbodiimide.
- Weinreb_ketone_synthesis wikiPageWikiLink Carbon–carbon_bond.
- Weinreb_ketone_synthesis wikiPageWikiLink Category:Carbon-carbon_bond_forming_reactions.
- Weinreb_ketone_synthesis wikiPageWikiLink Category:Name_reactions.
- Weinreb_ketone_synthesis wikiPageWikiLink Category:Substitution_reactions.
- Weinreb_ketone_synthesis wikiPageWikiLink Chelation.
- Weinreb_ketone_synthesis wikiPageWikiLink Chiral_auxiliary.
- Weinreb_ketone_synthesis wikiPageWikiLink Enamine.
- Weinreb_ketone_synthesis wikiPageWikiLink Enol.
- Weinreb_ketone_synthesis wikiPageWikiLink Enolate.
- Weinreb_ketone_synthesis wikiPageWikiLink Equivalent_(chemistry).
- Weinreb_ketone_synthesis wikiPageWikiLink Ester.
- Weinreb_ketone_synthesis wikiPageWikiLink Functional_group.
- Weinreb_ketone_synthesis wikiPageWikiLink Grignard_reaction.
- Weinreb_ketone_synthesis wikiPageWikiLink Grignard_reagent.
- Weinreb_ketone_synthesis wikiPageWikiLink Hydroxybenzotriazole.
- Weinreb_ketone_synthesis wikiPageWikiLink Immunosuppressant.
- Weinreb_ketone_synthesis wikiPageWikiLink Immunosuppression.
- Weinreb_ketone_synthesis wikiPageWikiLink Ketone.
- Weinreb_ketone_synthesis wikiPageWikiLink Ketones.
- Weinreb_ketone_synthesis wikiPageWikiLink Lactam.
- Weinreb_ketone_synthesis wikiPageWikiLink Lactams.
- Weinreb_ketone_synthesis wikiPageWikiLink Lactone.
- Weinreb_ketone_synthesis wikiPageWikiLink Lithium_aluminium_hydride.
- Weinreb_ketone_synthesis wikiPageWikiLink Methoxy.
- Weinreb_ketone_synthesis wikiPageWikiLink N,O-Dimethylhydroxylamine.
- Weinreb_ketone_synthesis wikiPageWikiLink Natural_product.
- Weinreb_ketone_synthesis wikiPageWikiLink Nucleophile.
- Weinreb_ketone_synthesis wikiPageWikiLink Nucleophilic_acyl_substitution.
- Weinreb_ketone_synthesis wikiPageWikiLink Organic_chemistry.
- Weinreb_ketone_synthesis wikiPageWikiLink Organolithium.
- Weinreb_ketone_synthesis wikiPageWikiLink Organolithium_reagent.
- Weinreb_ketone_synthesis wikiPageWikiLink Organometallic.
- Weinreb_ketone_synthesis wikiPageWikiLink Organometallic_chemistry.
- Weinreb_ketone_synthesis wikiPageWikiLink Oxford.
- Weinreb_ketone_synthesis wikiPageWikiLink Peptide_synthesis.
- Weinreb_ketone_synthesis wikiPageWikiLink Pseudoephedrine.
- Weinreb_ketone_synthesis wikiPageWikiLink Reaction_mechanism.
- Weinreb_ketone_synthesis wikiPageWikiLink Redox.
- Weinreb_ketone_synthesis wikiPageWikiLink Silyl_ether.
- Weinreb_ketone_synthesis wikiPageWikiLink Stephen_G._Davies.
- Weinreb_ketone_synthesis wikiPageWikiLink Steven_M._Weinreb.
- Weinreb_ketone_synthesis wikiPageWikiLink Sulfonates.
- Weinreb_ketone_synthesis wikiPageWikiLink Sulfonic_acid.
- Weinreb_ketone_synthesis wikiPageWikiLink Synthon.
- Weinreb_ketone_synthesis wikiPageWikiLink Tetrahedral_carbonyl_addition_compound.
- Weinreb_ketone_synthesis wikiPageWikiLink Tetrahedral_intermediate.
- Weinreb_ketone_synthesis wikiPageWikiLink Triphenylphosphine.
- Weinreb_ketone_synthesis wikiPageWikiLink Weinreb_ketone_synthesis.
- Weinreb_ketone_synthesis wikiPageWikiLink Wittig_reaction.
- Weinreb_ketone_synthesis wikiPageWikiLink Work-up_(chemistry).
- Weinreb_ketone_synthesis wikiPageWikiLink File:Overaddition.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:WeinrebAmideIntro.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:WeinrebWittig.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebacid.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebaminocarb.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebdavies.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebelim.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebester.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebmechanism.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebonepot.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebsyntheses.png.
- Weinreb_ketone_synthesis wikiPageWikiLink File:Weinrebsynthons.png.
- Weinreb_ketone_synthesis wikiPageWikiLinkText "Scope".
- Weinreb_ketone_synthesis wikiPageWikiLinkText "Weinreb Amides".
- Weinreb_ketone_synthesis wikiPageWikiLinkText "Weinreb ketone synthesis".
- Weinreb_ketone_synthesis hasPhotoCollection Weinreb_ketone_synthesis.
- Weinreb_ketone_synthesis wikiPageUsesTemplate Template:Good_article.
- Weinreb_ketone_synthesis wikiPageUsesTemplate Template:Reflist.
- Weinreb_ketone_synthesis wikiPageUsesTemplate Template:Use_dmy_dates.
- Weinreb_ketone_synthesis subject Category:Carbon-carbon_bond_forming_reactions.
- Weinreb_ketone_synthesis subject Category:Name_reactions.
- Weinreb_ketone_synthesis subject Category:Substitution_reactions.
- Weinreb_ketone_synthesis hypernym Reaction.
- Weinreb_ketone_synthesis type Disease.
- Weinreb_ketone_synthesis type Eponym.
- Weinreb_ketone_synthesis type Reaction.
- Weinreb_ketone_synthesis comment "The Weinreb–Nahm ketone synthesis is a chemical reaction used in organic chemistry to make carbon–carbon bonds. It was discovered in 1981 by Steven M. Weinreb and Steven Nahm as a method to synthesize ketones.".