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- Warfarin abstract "Warfarin, also known by the brand names Coumadin among others, is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body, respectively. It was initially introduced in 1948 as a pesticide against rats and mice, and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s, warfarin was found to be effective and relatively safe for preventing thrombosis and thromboembolism in many disorders. It was approved for use as a medication in 1954, and has remained popular ever since. Warfarin is the most widely prescribed oral anticoagulant drug in North America.Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or "greens," since these typically contain large amounts of vitamin K1) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. A high INR predisposes patients to an increased risk of bleeding, while an INR below the therapeutic target indicates the dose of warfarin is insufficient to protect against thromboembolic events.Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1. Thus, the pharmacologic action may always be reversed by fresh vitamin K1. When administered, these drugs do not anticoagulate blood immediately. Instead, onset of their effect requires about two to three days before remaining active clotting factors have had time to naturally disappear in metabolism, and the duration of action of a single dose of warfarin is 2 to 5 days. Reversal of warfarin's effect by discontinuing its use, or by administering vitamin K1, requires a similar period of time.Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant originally discovered in spoiled sweet clover-based animal feeds. Dicoumarol, in turn, is derived from coumarin, a sweet-smelling but coagulation-inactive chemical found naturally in "sweet" clover (to which it gives its odor and name), tonka beans (also known as "cumaru" from which coumarin's name derives), and many other plants. The name 'warfarin' stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization that funded the key research, "WARF" for the Wisconsin Alumni Research Foundation and the ending "-arin", indicating its link with coumarin.".
- Warfarin atcPrefix "B01".
- Warfarin atcSuffix "AA03".
- Warfarin bioavailability "79.0".
- Warfarin casNumber "81-81-2".
- Warfarin chEBI "10033".
- Warfarin drugbank "DB00682".
- Warfarin fdaUniiCode "5Q7ZVV76EI".
- Warfarin iupacName "(RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one".
- Warfarin pubchem "54678486".
- Warfarin thumbnail Warfarin.svg?width=300.
- Warfarin wikiPageExternalLink dpdirect.jsp?name=Warfarin.
- Warfarin wikiPageExternalLink npgd0665.html.
- Warfarin wikiPageExternalLink ?ligand=RWF.
- Warfarin wikiPageExternalLink ?ligand=SWF.
- Warfarin wikiPageExternalLink e5.full.
- Warfarin wikiPageExternalLink www.mdcalc.com.
- Warfarin wikiPageExternalLink atria-bleeding-risk-score.
- Warfarin wikiPageExternalLink has-bled-score-for-major-bleeding-risk.
- Warfarin wikiPageExternalLink index.jsp?cid=26&scid=34.
- Warfarin wikiPageID "238097".
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- Warfarin wikiPageRevisionID "679114721".
- Warfarin wikiPageWikiLink 4-Hydroxycoumarins.
- Warfarin wikiPageWikiLink 4-hydroxycoumarin.
- Warfarin wikiPageWikiLink Acenocoumarol.
- Warfarin wikiPageWikiLink Adverse_drug_reaction.
- Warfarin wikiPageWikiLink American_College_of_Chest_Physicians.
- Warfarin wikiPageWikiLink Anion.
- Warfarin wikiPageWikiLink Anticoagulant.
- Warfarin wikiPageWikiLink Anticoagulation_in_pregnancy.
- Warfarin wikiPageWikiLink Antiphospholipid_syndrome.
- Warfarin wikiPageWikiLink Antiplatelet_drug.
- Warfarin wikiPageWikiLink Antithrombin.
- Warfarin wikiPageWikiLink Apiaceae.
- Warfarin wikiPageWikiLink Apixaban.
- Warfarin wikiPageWikiLink Aromatic.
- Warfarin wikiPageWikiLink Aromaticity.
- Warfarin wikiPageWikiLink Artificial_heart_valve.
- Warfarin wikiPageWikiLink Aspirin.
- Warfarin wikiPageWikiLink Atrial_fibrillation.
- Warfarin wikiPageWikiLink Bait_(luring_substance).
- Warfarin wikiPageWikiLink Bioaccumulation.
- Warfarin wikiPageWikiLink Biological_half-life.
- Warfarin wikiPageWikiLink Bird_of_prey.
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- Warfarin wikiPageWikiLink Birth_defect.
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- Warfarin wikiPageWikiLink Borage_oil.
- Warfarin wikiPageWikiLink Borage_seed_oil.
- Warfarin wikiPageWikiLink Brachydactyly.
- Warfarin wikiPageWikiLink Broad-spectrum_antibiotic.
- Warfarin wikiPageWikiLink Broccoli.
- Warfarin wikiPageWikiLink Brodifacoum.
- Warfarin wikiPageWikiLink CYP1A2.
- Warfarin wikiPageWikiLink CYP2C19.
- Warfarin wikiPageWikiLink CYP2C9.
- Warfarin wikiPageWikiLink CYP3A4.
- Warfarin wikiPageWikiLink Cabbage.
- Warfarin wikiPageWikiLink Calcaneus.
- Warfarin wikiPageWikiLink Calcification.
- Warfarin wikiPageWikiLink Calcium.
- Warfarin wikiPageWikiLink Carboxylation.
- Warfarin wikiPageWikiLink Category:Coumarin_drugs.
- Warfarin wikiPageWikiLink Category:Ketones.
- Warfarin wikiPageWikiLink Category:Rodenticides.
- Warfarin wikiPageWikiLink Category:Teratogens.
- Warfarin wikiPageWikiLink Category:Vitamin_K_antagonists.
- Warfarin wikiPageWikiLink Centers_for_Medicare_and_Medicaid_Services.
- Warfarin wikiPageWikiLink Central_nervous_system.
- Warfarin wikiPageWikiLink Cholesterol.
- Warfarin wikiPageWikiLink Cholesterol_embolism.
- Warfarin wikiPageWikiLink Cilantro.
- Warfarin wikiPageWikiLink Clinical_practice_guidelines.
- Warfarin wikiPageWikiLink Clopidogrel.
- Warfarin wikiPageWikiLink Clotting.
- Warfarin wikiPageWikiLink Coagulation.
- Warfarin wikiPageWikiLink Committee_on_Safety_of_Medicines.
- Warfarin wikiPageWikiLink Congenital_disorder.
- Warfarin wikiPageWikiLink Conjugate_addition.
- Warfarin wikiPageWikiLink Contraindication.
- Warfarin wikiPageWikiLink Coriander.
- Warfarin wikiPageWikiLink Coumarin.
- Warfarin wikiPageWikiLink Coumatetralyl.
- Warfarin wikiPageWikiLink Cranberry.
- Warfarin wikiPageWikiLink Cruciferous_vegetables.
- Warfarin wikiPageWikiLink Dabigatran.
- Warfarin wikiPageWikiLink Deep_vein_thrombosis.
- Warfarin wikiPageWikiLink Deep_venous_thrombosis.
- Warfarin wikiPageWikiLink Des-gamma_carboxyprothrombin.
- Warfarin wikiPageWikiLink Developmental_disability.
- Warfarin wikiPageWikiLink Dicoumarol.
- Warfarin wikiPageWikiLink Dill.
- Warfarin wikiPageWikiLink Dipteryx_odorata.