Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Von_Willebrand_factor_type_A_domain> ?p ?o }
- Von_Willebrand_factor_type_A_domain abstract "The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands. Fold recognition algorithms were used to score sequence compatibility with a library of known structures: the vWF domain fold was predicted to be a doubly wound, open, twisted beta-sheet flanked by alpha-helices. 3D structures have been determined for the I-domains of integrins CD11b (with bound magnesium) and CD11a (with bound manganese). The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. The residues constituting the MIDAS motif in the CD11b and CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly.".
- Von_Willebrand_factor_type_A_domain symbol "VWA".
- Von_Willebrand_factor_type_A_domain thumbnail PDB_1lfa_EBI.jpg?width=300.
- Von_Willebrand_factor_type_A_domain wikiPageID "24010016".
- Von_Willebrand_factor_type_A_domain wikiPageLength "7895".
- Von_Willebrand_factor_type_A_domain wikiPageOutDegree "64".
- Von_Willebrand_factor_type_A_domain wikiPageRevisionID "593289208".
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ANTXR1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ANTXR2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Alpha-helices.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Alpha_helix.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink BF_(protein).
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Beta-sheet.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Beta_sheet.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CACHD1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CACNA2D1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CACNA2D2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CACNA2D3.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CACNA2D4.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CD11a.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CD11c.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CD49a.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CD49b.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CLCA1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CLCA2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CLCA4.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COCH.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL12A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL14A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL20A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL21A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL22A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL28.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL6A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL6A2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL6A3.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COL7A1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink COLA1L.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink CaCC1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Category:Protein_domains.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Category:Single-pass_transmembrane_proteins.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Collagen,_type_VI,_alpha_1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Collagen,_type_VII,_alpha_1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Collagen,_type_XII,_alpha_1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Collagen,_type_XIV,_alpha_1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Complement_component_2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Complement_factor_B.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Glycoprotein.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink HCLCA1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink HCLCA2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGA1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGA10.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGA11.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGA2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGAD.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGAE.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGAL.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGAM.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITGAX.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH3.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH4.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH5.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink ITIH5L.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Integrin_alpha_M.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink LOC285929.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink LOC340267.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink LOC389462.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink LOH11CR2A.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink MATN1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink MATN2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink MATN3.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink MATN4.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink PARP4.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Proteasome.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink SEL-OB.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink SVEP1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink VIT_(protein).
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink VWA1.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink VWA2.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLink Von_Willebrand_factor.
- Von_Willebrand_factor_type_A_domain wikiPageWikiLinkText "Von Willebrand factor type A domain".
- Von_Willebrand_factor_type_A_domain wikiPageWikiLinkText "von Willebrand factor A".
- Von_Willebrand_factor_type_A_domain wikiPageWikiLinkText "von Willebrand factor type A domain".
- Von_Willebrand_factor_type_A_domain caption "Structure of the I-domain from the CD11a/CD18 integrin.".
- Von_Willebrand_factor_type_A_domain cdd "cd00198".
- Von_Willebrand_factor_type_A_domain hasPhotoCollection Von_Willebrand_factor_type_A_domain.
- Von_Willebrand_factor_type_A_domain interpro "IPR002035".
- Von_Willebrand_factor_type_A_domain name "von Willebrand factor type A domain".
- Von_Willebrand_factor_type_A_domain pdb "X:44-213 i:44-213 X:44-213 Y:44-212 A:270-468 A:270-468 A:270-468 A:270-468 A:172-331 A:172-338 A:172-333 B:172-355 B:172-355 A:174-355 A:174-361 C:174-361 A:174-361 B:1691-1864 B:1691-1864 C:1691-1864 A:1691-1864 A:150-328 1:150-328 2:150-328 2:150-328 :150-328 :150-328 A:150-328 A:150-328 A:150-328 A:151-329 A:156-327 A:156-327 B:156-327 A:156-327 A:156-327 A:156-327 :156-327 B:156-327 L:156-327 C:156-327 A:156-327 B:156-327 B:156-327 B:156-327 A:156-327 A:156-326 A:1277-1457 A:1277-1457 A:1277-1457 A:1277-1457 :1277-1457 A:1277-1457 C:1277-1457 A:1277-1457 A:1277-1457 C:1277-1453".
- Von_Willebrand_factor_type_A_domain pfam "PF00092".
- Von_Willebrand_factor_type_A_domain scop "1".
- Von_Willebrand_factor_type_A_domain symbol "VWA".
- Von_Willebrand_factor_type_A_domain wikiPageUsesTemplate Template:Cite_journal.
- Von_Willebrand_factor_type_A_domain wikiPageUsesTemplate Template:ELM.
- Von_Willebrand_factor_type_A_domain wikiPageUsesTemplate Template:InterPro_content.
- Von_Willebrand_factor_type_A_domain wikiPageUsesTemplate Template:Pfam_box.
- Von_Willebrand_factor_type_A_domain wikiPageUsesTemplate Template:Reflist.
- Von_Willebrand_factor_type_A_domain subject Category:Protein_domains.