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- Voltage-gated_proton_channel abstract "Voltage-gated proton channels are ion channels that have the unique property of opening with depolarization, but in a strongly pH-sensitive manner. The result is that these channels open only when the electrochemical gradient is outward, such that their opening will only allow protons to leave cells. Their function thus appears to be acid extrusion from cells.Another important function occurs in phagocytes (e.g. eosinophils, neutrophils, and macrophages) during the respiratory burst. When bacteria or other microbes are engulfed by phagocytes, the enzyme NADPH oxidase assembles in the membrane and begins to produce reactive oxygen species (ROS) that help kill bacteria. NADPH oxidase is electrogenic, moving electrons across the membrane, and proton channels open to allow proton flux to balance the electron movement electrically.A group of small molecule inhibitors of the Hv1 channel are shown as chemotherapeutics and anti-inflammatory agents.".
- Voltage-gated_proton_channel wikiPageID "13437576".
- Voltage-gated_proton_channel wikiPageLength "3727".
- Voltage-gated_proton_channel wikiPageOutDegree "19".
- Voltage-gated_proton_channel wikiPageRevisionID "645092443".
- Voltage-gated_proton_channel wikiPageWikiLink Acid.
- Voltage-gated_proton_channel wikiPageWikiLink Bacteria.
- Voltage-gated_proton_channel wikiPageWikiLink Category:Immunology.
- Voltage-gated_proton_channel wikiPageWikiLink Category:Ion_channels.
- Voltage-gated_proton_channel wikiPageWikiLink Cell_(biology).
- Voltage-gated_proton_channel wikiPageWikiLink Depolarization.
- Voltage-gated_proton_channel wikiPageWikiLink Electrochemical_gradient.
- Voltage-gated_proton_channel wikiPageWikiLink Enzyme.
- Voltage-gated_proton_channel wikiPageWikiLink Eosinophil.
- Voltage-gated_proton_channel wikiPageWikiLink Eosinophil_granulocyte.
- Voltage-gated_proton_channel wikiPageWikiLink HVCN1.
- Voltage-gated_proton_channel wikiPageWikiLink Ion_channel.
- Voltage-gated_proton_channel wikiPageWikiLink Macrophage.
- Voltage-gated_proton_channel wikiPageWikiLink Microbe.
- Voltage-gated_proton_channel wikiPageWikiLink Microorganism.
- Voltage-gated_proton_channel wikiPageWikiLink NADPH_oxidase.
- Voltage-gated_proton_channel wikiPageWikiLink Neutrophil.
- Voltage-gated_proton_channel wikiPageWikiLink Neutrophil_granulocyte.
- Voltage-gated_proton_channel wikiPageWikiLink PH.
- Voltage-gated_proton_channel wikiPageWikiLink Phagocyte.
- Voltage-gated_proton_channel wikiPageWikiLink Reactive_oxygen_species.
- Voltage-gated_proton_channel wikiPageWikiLink Respiratory_burst.
- Voltage-gated_proton_channel wikiPageWikiLinkText "Voltage-gated proton channel".
- Voltage-gated_proton_channel wikiPageWikiLinkText "proton channel".
- Voltage-gated_proton_channel wikiPageWikiLinkText "voltage-gated proton channel".
- Voltage-gated_proton_channel hasPhotoCollection Voltage-gated_proton_channel.
- Voltage-gated_proton_channel wikiPageUsesTemplate Template:Ion_channels.
- Voltage-gated_proton_channel wikiPageUsesTemplate Template:Refimprove.
- Voltage-gated_proton_channel wikiPageUsesTemplate Template:Reflist.
- Voltage-gated_proton_channel subject Category:Immunology.
- Voltage-gated_proton_channel subject Category:Ion_channels.
- Voltage-gated_proton_channel hypernym Channels.
- Voltage-gated_proton_channel type Article.
- Voltage-gated_proton_channel type TelevisionStation.
- Voltage-gated_proton_channel type Article.
- Voltage-gated_proton_channel type Biophysic.
- Voltage-gated_proton_channel type Channel.
- Voltage-gated_proton_channel type Specialty.
- Voltage-gated_proton_channel comment "Voltage-gated proton channels are ion channels that have the unique property of opening with depolarization, but in a strongly pH-sensitive manner. The result is that these channels open only when the electrochemical gradient is outward, such that their opening will only allow protons to leave cells. Their function thus appears to be acid extrusion from cells.Another important function occurs in phagocytes (e.g. eosinophils, neutrophils, and macrophages) during the respiratory burst.".
- Voltage-gated_proton_channel label "Voltage-gated proton channel".
- Voltage-gated_proton_channel sameAs m.03c5b1p.
- Voltage-gated_proton_channel sameAs Q7940729.
- Voltage-gated_proton_channel sameAs Q7940729.
- Voltage-gated_proton_channel wasDerivedFrom Voltage-gated_proton_channel?oldid=645092443.
- Voltage-gated_proton_channel isPrimaryTopicOf Voltage-gated_proton_channel.