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- U-90042 abstract "U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6. It produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys, but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to benzodiazepine drugs. It was developed by a team at Novo Nordisk in the 1980s.".
- U-90042 casNumber "134516-99-7".
- U-90042 iupacName "11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,2-c:1',5'-a]quinazoline".
- U-90042 pubchem "9928470".
- U-90042 thumbnail U-90042.png?width=300.
- U-90042 wikiPageID "18324309".
- U-90042 wikiPageLength "3278".
- U-90042 wikiPageOutDegree "15".
- U-90042 wikiPageRevisionID "673940191".
- U-90042 wikiPageWikiLink Amnesia.
- U-90042 wikiPageWikiLink Ataxia.
- U-90042 wikiPageWikiLink Benzodiazepine.
- U-90042 wikiPageWikiLink Category:Chloroarenes.
- U-90042 wikiPageWikiLink Category:Cyclopropanes.
- U-90042 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- U-90042 wikiPageWikiLink Category:Oxadiazoles.
- U-90042 wikiPageWikiLink Category:Sedatives.
- U-90042 wikiPageWikiLink Diazepam.
- U-90042 wikiPageWikiLink Dissociation_constant.
- U-90042 wikiPageWikiLink GABAA_receptor.
- U-90042 wikiPageWikiLink GABA_A_receptor.
- U-90042 wikiPageWikiLink Hypnotic.
- U-90042 wikiPageWikiLink Nonbenzodiazepine.
- U-90042 wikiPageWikiLink Sedation.
- U-90042 wikiPageWikiLink Sedative.
- U-90042 c "17".
- U-90042 casNumber "134516".
- U-90042 chemspiderid "8104103".
- U-90042 cl "1".
- U-90042 h "13".
- U-90042 hasPhotoCollection U-90042.
- U-90042 inchi "1".
- U-90042 inchikey "CLPSAAPUJUVQPP-UHFFFAOYAK".
- U-90042 iupacName "60.0".
- U-90042 molecularWeight "352.78".
- U-90042 n "6".
- U-90042 o "1".
- U-90042 pubchem "9928470".
- U-90042 smiles "ClC1=CC2=CN3C=NC=C3N6C2=NCC6".
- U-90042 stdinchi "1".
- U-90042 stdinchikey "CLPSAAPUJUVQPP-UHFFFAOYSA-N".
- U-90042 verifiedfields "changed".
- U-90042 verifiedrevid "448131874".
- U-90042 watchedfields "changed".
- U-90042 width "140".
- U-90042 wikiPageUsesTemplate Template:Drugbox.
- U-90042 wikiPageUsesTemplate Template:GABAAR_PAMs.
- U-90042 wikiPageUsesTemplate Template:Hypnotics_and_sedatives.
- U-90042 wikiPageUsesTemplate Template:Sedative-stub.
- U-90042 subject Category:Chloroarenes.
- U-90042 subject Category:Cyclopropanes.
- U-90042 subject Category:GABAA_receptor_positive_allosteric_modulators.
- U-90042 subject Category:Oxadiazoles.
- U-90042 subject Category:Sedatives.
- U-90042 hypernym Sedative.
- U-90042 type Article.
- U-90042 type ChemicalSubstance.
- U-90042 type Drug.
- U-90042 type Article.
- U-90042 type Chemical.
- U-90042 type Drug.
- U-90042 type Heterocycle.
- U-90042 type Organohalide.
- U-90042 type Organohalide.
- U-90042 type ChemicalObject.
- U-90042 type Thing.
- U-90042 type Q8386.
- U-90042 comment "U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6.".
- U-90042 label "U-90042".
- U-90042 sameAs m.04cy166.
- U-90042 sameAs U-90042.
- U-90042 sameAs U-90042.
- U-90042 sameAs Q15410174.
- U-90042 sameAs Q15410174.
- U-90042 wasDerivedFrom U-90042?oldid=673940191.
- U-90042 depiction U-90042.png.
- U-90042 isPrimaryTopicOf U-90042.