Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Tryptophan-rich_sensory_protein> ?p ?o }
- Tryptophan-rich_sensory_protein abstract "Tryptophan-rich sensory proteins (TspO) are a family of proteins that are involved in transmembrane signalling. In both prokaryotes and mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. They are associated with the major outer membrane porins (in prokaryotes) and with the voltage-dependent anion channel (in mitochondria).TspO of Rhodobacter sphaeroides is involved in signal transduction, functioning as a negative regulator of the expression of some photosynthesis genes (PpsR/AppA repressor/antirepressor regulon). This down-regulation is believed to be in response to oxygen levels. TspO works through (or modulates) the PpsR/AppA system and acts upstream of the site of action of these regulatory proteins. It has been suggested that the TspO regulatory pathway works by regulating the efflux of certain tetrapyrrole intermediates of the haem/bacteriochlorophyll biosynthetic pathways in response to the availability of molecular oxygen, thereby causing the accumulation of a biosynthetic intermediate that serves as a corepressor for the regulated genes. A homologue of the TspO protein in Rhizobium meliloti is involved in regulating expression of the ndi locus in response to stress conditions.In animals, the peripheral benzodiazepine receptor is a mitochondrial protein (located in the outer mitochondrial membrane) characterised by its ability to bind with nanomolar affinity to a variety of benzodiazepine-like drugs, as well as to dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. Depending upon the tissue, it was shown to be involved in steroidogenesis, haem biosynthesis, apoptosis, cell growth and differentiation, mitochondrial respiratory control, and immune and stress response, but the precise function of the PBR remains unclear. The role of PBR in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis, has been studied in detail. PBR is required for the binding, uptake and release, upon ligand activation, of the substrate cholesterol. PBR forms a multimeric complex with the voltage-dependent anion channel (VDAC) and adenine nucleotide carrier. Molecular modeling of PBR suggested that it might function as a channel for cholesterol. Indeed, cholesterol uptake and transport by bacterial cells was induced upon PBR expression. Mutagenesis studies identified a cholesterol recognition/interaction motif (CRAC) in the cytoplasmic C terminus of PBR.In complementation experiments, rat PBR (pk18) protein functionally substitutes for its homologue TspO in R. sphaeroides, negatively affecting transcription of specific photosynthesis genes. This suggests that PBR may function as an oxygen sensor, transducing an oxygen-triggered signal leading to an adaptive cellular response.These observations suggest that fundamental aspects of this receptor and the downstream signal transduction pathway are conserved in bacteria and higher eukaryotic mitochondria. The alpha-3 subdivision of the purple bacteria is considered to be a likely source of the endosymbiont that ultimately gave rise to the mitochondrion. Therefore, it is possible that the mammalian PBR remains both evolutionarily and functionally related to the TspO of R. sphaeroides.".
- Tryptophan-rich_sensory_protein symbol "TspO_MBR".
- Tryptophan-rich_sensory_protein wikiPageID "35853778".
- Tryptophan-rich_sensory_protein wikiPageLength "8494".
- Tryptophan-rich_sensory_protein wikiPageOutDegree "60".
- Tryptophan-rich_sensory_protein wikiPageRevisionID "608371462".
- Tryptophan-rich_sensory_protein wikiPageWikiLink Adenine_nucleotide.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Adenine_nucleotide_translocator.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Apoptosis.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Benzodiazepine.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Biosynthetic_pathway.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Category:Protein_families.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Category:Signal_transduction.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Category:Transmembrane_proteins.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cell_(biology).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cell_growth.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cell_signaling.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cell_signalling.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cholesterol.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Complementation_(genetics).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Complementation_experiments.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Corepressor.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Corepressor_(genetics).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Cytoplasm.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Efflux_(microbiology).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Electron_transport_chain.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Enzyme_substrate.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Expression_(genetics).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Fight-or-flight_response.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Gene.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Gene_expression.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Gene_regulation.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Haem.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Haem_biosynthesis.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Heme.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Homology_(biology).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Immune_system.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Ligand_(biochemistry).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Locus_(genetics).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Metabolism.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Mitochondria.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Mitochondrion.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Molecular_binding.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Multiprotein_complex.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Mutagenesis.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Outer_mitochondrial_membrane.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Oxygen.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Peripheral_benzodiazepine_receptor.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Photosynthesis.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Porin_(protein).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Prokaryote.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Prokaryotes.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Protein.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Protein_complex.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Protein_motif.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Purple_bacteria.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Rat.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Reaction_intermediate.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Regulation_of_gene_expression.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Regulon.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Rhizobium_meliloti.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Rhodobacter_sphaeroides.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Signal_transduction.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Signal_transduction_pathway.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Sinorhizobium_meliloti.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Steroid.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Steroidogenesis.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Stress_(biology).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Stress_(medicine).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Stress_response.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Structural_motif.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Substrate_(chemistry).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Tetrapyrrole.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Transcription_(genetics).
- Tryptophan-rich_sensory_protein wikiPageWikiLink Translocator_protein.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Upstream_and_downstream_(DNA).
- Tryptophan-rich_sensory_protein wikiPageWikiLink VDAC.
- Tryptophan-rich_sensory_protein wikiPageWikiLink Voltage-dependent_anion_channel.
- Tryptophan-rich_sensory_protein wikiPageWikiLinkText "tryptophan-rich sensory protein".
- Tryptophan-rich_sensory_protein hasPhotoCollection Tryptophan-rich_sensory_protein.
- Tryptophan-rich_sensory_protein interpro "IPR004307".
- Tryptophan-rich_sensory_protein name "TspO_MBR".
- Tryptophan-rich_sensory_protein pfam "PF03073".
- Tryptophan-rich_sensory_protein symbol "TspO_MBR".
- Tryptophan-rich_sensory_protein wikiPageUsesTemplate Template:Infobox_protein_family.
- Tryptophan-rich_sensory_protein wikiPageUsesTemplate Template:InterPro_content.
- Tryptophan-rich_sensory_protein wikiPageUsesTemplate Template:Reflist.
- Tryptophan-rich_sensory_protein subject Category:Protein_families.
- Tryptophan-rich_sensory_protein subject Category:Signal_transduction.
- Tryptophan-rich_sensory_protein subject Category:Transmembrane_proteins.
- Tryptophan-rich_sensory_protein hypernym Family.
- Tryptophan-rich_sensory_protein type Biomolecule.
- Tryptophan-rich_sensory_protein type Protein.
- Tryptophan-rich_sensory_protein type Thing.
- Tryptophan-rich_sensory_protein type Q206229.
- Tryptophan-rich_sensory_protein type Q8054.
- Tryptophan-rich_sensory_protein comment "Tryptophan-rich sensory proteins (TspO) are a family of proteins that are involved in transmembrane signalling. In both prokaryotes and mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway.".
- Tryptophan-rich_sensory_protein label "Tryptophan-rich sensory protein".
- Tryptophan-rich_sensory_protein sameAs m.0jwsnfq.
- Tryptophan-rich_sensory_protein sameAs Q7848802.