Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Trichostatin_A> ?p ?o }
- Trichostatin_A abstract "Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis-related genes, leading to cancerous cells surviving at lower rates, thus slowing the progression of cancer. Other mechanisms may include the activity of HDIs to induce cell differentiation, thus acting to "mature" some of the de-differentiated cells found in tumors. HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.TSA represses IL (interleukin)-1β/LPS (lipopolysaccharide)/IFNγ (interferon γ)-induced nitric oxide synthase (NOS)2 expression in murine macrophage-like cells but increases LPS-stimulated NOS2 expression in murine N9 and primary rat microglial cells.TSA has not been tested in clinical trials as of 2013-05-27.".
- Trichostatin_A atcPrefix "none".
- Trichostatin_A casNumber "58880-19-6".
- Trichostatin_A chEBI "46024".
- Trichostatin_A drugbank "DB04297".
- Trichostatin_A iupacName "7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide".
- Trichostatin_A pubchem "444732".
- Trichostatin_A thumbnail Trichostatin_A.svg?width=300.
- Trichostatin_A wikiPageExternalLink trichostatin_A-MSDS.htm.
- Trichostatin_A wikiPageID "3181579".
- Trichostatin_A wikiPageLength "5521".
- Trichostatin_A wikiPageOutDegree "31".
- Trichostatin_A wikiPageRevisionID "667237250".
- Trichostatin_A wikiPageWikiLink Acetyl.
- Trichostatin_A wikiPageWikiLink Apoptosis.
- Trichostatin_A wikiPageWikiLink Cancer.
- Trichostatin_A wikiPageWikiLink Category:Anilines.
- Trichostatin_A wikiPageWikiLink Category:Antibiotics.
- Trichostatin_A wikiPageWikiLink Category:Aromatic_ketones.
- Trichostatin_A wikiPageWikiLink Category:Histone_deacetylase_inhibitors.
- Trichostatin_A wikiPageWikiLink Category:Hydroxamic_acids.
- Trichostatin_A wikiPageWikiLink Cell_cycle.
- Trichostatin_A wikiPageWikiLink Chromatin.
- Trichostatin_A wikiPageWikiLink DNA.
- Trichostatin_A wikiPageWikiLink Enzyme.
- Trichostatin_A wikiPageWikiLink Enzyme_inhibitor.
- Trichostatin_A wikiPageWikiLink Eukaryote.
- Trichostatin_A wikiPageWikiLink Fermentek.
- Trichostatin_A wikiPageWikiLink Gene.
- Trichostatin_A wikiPageWikiLink Gene_expression.
- Trichostatin_A wikiPageWikiLink Histone.
- Trichostatin_A wikiPageWikiLink Histone_deacetylase.
- Trichostatin_A wikiPageWikiLink Histone_deacetylase_inhibitor.
- Trichostatin_A wikiPageWikiLink Histone_deacetylases.
- Trichostatin_A wikiPageWikiLink Histones.
- Trichostatin_A wikiPageWikiLink IC50.
- Trichostatin_A wikiPageWikiLink IL1B.
- Trichostatin_A wikiPageWikiLink Interferon_gamma.
- Trichostatin_A wikiPageWikiLink Interferon_γ.
- Trichostatin_A wikiPageWikiLink Lipopolysaccharide.
- Trichostatin_A wikiPageWikiLink Nitric_oxide_synthase.
- Trichostatin_A wikiPageWikiLink Sirtuin.
- Trichostatin_A wikiPageWikiLink Teratogenic.
- Trichostatin_A wikiPageWikiLink Teratology.
- Trichostatin_A wikiPageWikiLink Transcription_factor.
- Trichostatin_A wikiPageWikiLink Transcription_factors.
- Trichostatin_A wikiPageWikiLink Vorinostat.
- Trichostatin_A wikiPageWikiLinkText "Trichostatin A (TSA)".
- Trichostatin_A wikiPageWikiLinkText "Trichostatin A".
- Trichostatin_A wikiPageWikiLinkText "trichostatin A".
- Trichostatin_A alt "Space-filling model of the trichostatin A molecule".
- Trichostatin_A alt "Structural formula of trichostatin A".
- Trichostatin_A atcPrefix "none".
- Trichostatin_A c "17".
- Trichostatin_A casNumber "58880".
- Trichostatin_A chebi "46024".
- Trichostatin_A chembl "99".
- Trichostatin_A chemspiderid "392575".
- Trichostatin_A drugbank "DB04297".
- Trichostatin_A h "22".
- Trichostatin_A hasPhotoCollection Trichostatin_A.
- Trichostatin_A image "Trichostatin A 3D spacefill.png".
- Trichostatin_A inchi "1".
- Trichostatin_A inchikey "RTKIYFITIVXBLE-QEQCGCAPBF".
- Trichostatin_A iupacName "7".
- Trichostatin_A iupharLigand "7005".
- Trichostatin_A molecularWeight "302.37".
- Trichostatin_A n "2".
- Trichostatin_A o "3".
- Trichostatin_A pregnancyCategory "D—teratogenic".
- Trichostatin_A pubchem "444732".
- Trichostatin_A smiles "O=C\C=C\CC".
- Trichostatin_A stdinchi "1".
- Trichostatin_A stdinchikey "RTKIYFITIVXBLE-QEQCGCAPSA-N".
- Trichostatin_A verifiedfields "changed".
- Trichostatin_A verifiedrevid "470613588".
- Trichostatin_A width "250".
- Trichostatin_A wikiPageUsesTemplate Template:Cite_journal.
- Trichostatin_A wikiPageUsesTemplate Template:Drugbox.
- Trichostatin_A wikiPageUsesTemplate Template:Reflist.
- Trichostatin_A subject Category:Anilines.
- Trichostatin_A subject Category:Antibiotics.
- Trichostatin_A subject Category:Aromatic_ketones.
- Trichostatin_A subject Category:Histone_deacetylase_inhibitors.
- Trichostatin_A subject Category:Hydroxamic_acids.
- Trichostatin_A hypernym Compound.
- Trichostatin_A type ChemicalCompound.
- Trichostatin_A type ChemicalSubstance.
- Trichostatin_A type Drug.
- Trichostatin_A type Group.
- Trichostatin_A type Chemical.
- Trichostatin_A type Drug.
- Trichostatin_A type Enamine.
- Trichostatin_A type Group.
- Trichostatin_A type Inhibitor.
- Trichostatin_A type Ketone.
- Trichostatin_A type Product.
- Trichostatin_A type ChemicalObject.
- Trichostatin_A type Thing.
- Trichostatin_A type Q8386.