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- Trevena_Inc abstract "Trevena Inc a clinical stage biopharmaceutical company, headquartered in King of Prussia, PA, and is the leader in the discovery and development of G-protein coupled receptors (GPCR) biased ligands. Trevena was founded with technology licensed from Duke University, which originated in the labs of company founders Robert Lefkowitz winner of the 2012 Nobel Prize in Chemistry and Howard Rockman. Trevena's innovative approach to drug discovery is based on utilizing ligand bias, or functional selectivity, at GPCR targets to produce drugs with improved efficacy and reduced side effect profiles. In 2008, the company raised $25 Million in a Series A financing round led by Alta Partners, Polaris Ventures, New Enterprise Associates, Healthcare Ventures, and Yasuda Economic Development Corporation. Trevena was named one of the top 15 US startups of 2008 by Business Week. The company raised an additional $35 million USD in a B round of venture financing in the summer of 2010.Trevena's lead program, TRV027 for acute heart failure, targets the angiotensin receptor utilizing beta-arrestin bias, an approach that has shown numerous beneficial cardiovascular and renal actions in preclinical species. Trevena completed Phase I clinical trials in 2010. Phase 2 clinical trials on TRV027 began in the spring of 2011.Trevena is also developing TRV130, a G protein-biased ligand for the intravenous treatment of acute moderate-to-severe post-operative pain. The Phase I first-in-human clinical trial of TRV130 is complete. The drug was safe and generally well-tolerated in this study, with pharmacodynamic effects recapitulating its exciting preclinical profile. The next clinical study of TRV130 will investigate analgesic efficacy and tolerability, and will include intravenous morphine, a gold-standard post-operative analgesic, as a comparator. Trevena’s expertise lies in engineering "biased ligands" that activate only the beneficial signaling pathways downstream of a GPCR to unlock new biology and avoid drug adverse effects. In addition to TRV027, Trevena’s pipeline currently includes a clinical stage mu-opioid biased ligand for post-operative pain, and discovery-stage programs for chronic pain, and Parkinson’s disease. In early 2009, Trevena entered into a collaborative agreement with Ligand Pharmaceuticals to identify biased ligands at numerous GPCRs from a large, diverse chemical library. Later that year, Trevena received a competitively awarded American Recovery and Reinvestment Act Grand Opportunities Grant, spanning two years and funding $7.65 million USD of research. The company has disclosed specific interests in the mu Opioid receptor and kappa Opioid receptor. In 2011, Treveva received another NIH grant as part of the NIH Blueprint Neurotherapeutics Network, potentially worth up to $10M USD, to support preclinical development of a delta opioid receptor biased ligand for major depressive disorder. Trevena has received funding from the Michael J. Fox Foundation to explore the potential for delta opioid receptor biased ligands to treat Parkinson's disease.".
- Trevena_Inc locationCity King_of_Prussia,_Pennsylvania.
- Trevena_Inc locationCountry United_States.
- Trevena_Inc thumbnail Trevena-logo.gif?width=300.
- Trevena_Inc type Public_company.
- Trevena_Inc wikiPageExternalLink www.trevenainc.com.
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- Trevena_Inc wikiPageWikiLink American_Recovery_and_Reinvestment_Act.
- Trevena_Inc wikiPageWikiLink American_Recovery_and_Reinvestment_Act_of_2009.
- Trevena_Inc wikiPageWikiLink Angiotensin_receptor.
- Trevena_Inc wikiPageWikiLink Biopharmaceutical.
- Trevena_Inc wikiPageWikiLink Category:Biotechnology_companies_of_the_United_States.
- Trevena_Inc wikiPageWikiLink Category:Companies_based_in_Pennsylvania.
- Trevena_Inc wikiPageWikiLink Category:Companies_listed_on_NASDAQ.
- Trevena_Inc wikiPageWikiLink Category:Pharmaceutical_companies_of_the_United_States.
- Trevena_Inc wikiPageWikiLink Category:Privately_held_companies_based_in_Pennsylvania.
- Trevena_Inc wikiPageWikiLink Delta_opioid_receptor.
- Trevena_Inc wikiPageWikiLink Duke_University.
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- Trevena_Inc wikiPageWikiLink Functional_selectivity.
- Trevena_Inc wikiPageWikiLink G-protein_coupled_receptors.
- Trevena_Inc wikiPageWikiLink G_protein–coupled_receptor.
- Trevena_Inc wikiPageWikiLink Heart_failure.
- Trevena_Inc wikiPageWikiLink Kappa_Opioid_receptor.
- Trevena_Inc wikiPageWikiLink King_of_Prussia,_Pennsylvania.
- Trevena_Inc wikiPageWikiLink Major_depressive_disorder.
- Trevena_Inc wikiPageWikiLink Michael_J._Fox_Foundation.
- Trevena_Inc wikiPageWikiLink Mu_Opioid_receptor.
- Trevena_Inc wikiPageWikiLink New_Enterprise_Associates.
- Trevena_Inc wikiPageWikiLink Nobel_Prize.
- Trevena_Inc wikiPageWikiLink Parkinsons_disease.
- Trevena_Inc wikiPageWikiLink Polaris_Partners.
- Trevena_Inc wikiPageWikiLink Polaris_Ventures.
- Trevena_Inc wikiPageWikiLink Public_company.
- Trevena_Inc wikiPageWikiLink Robert_Lefkowitz.
- Trevena_Inc wikiPageWikiLink TRV130.
- Trevena_Inc wikiPageWikiLink The_Michael_J._Fox_Foundation.
- Trevena_Inc wikiPageWikiLink USA.
- Trevena_Inc wikiPageWikiLink United_States.
- Trevena_Inc wikiPageWikiLink Δ-opioid_receptor.
- Trevena_Inc wikiPageWikiLink Κ-opioid_receptor.
- Trevena_Inc wikiPageWikiLink Μ-opioid_receptor.
- Trevena_Inc wikiPageWikiLinkText "Trevena Inc".
- Trevena_Inc hasPhotoCollection Trevena_Inc.
- Trevena_Inc homepage www.trevenainc.com.
- Trevena_Inc industry "Biotechnology / Pharmaceutical".
- Trevena_Inc keyPeople "Maxine Gowen , Michael Lark".
- Trevena_Inc locationCity King_of_Prussia,_Pennsylvania.
- Trevena_Inc locationCountry USA.
- Trevena_Inc locationCountry United_States.
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- Trevena_Inc name "Trevena Inc".
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- Trevena_Inc subject Category:Biotechnology_companies_of_the_United_States.
- Trevena_Inc subject Category:Companies_based_in_Pennsylvania.
- Trevena_Inc subject Category:Companies_listed_on_NASDAQ.
- Trevena_Inc subject Category:Pharmaceutical_companies_of_the_United_States.
- Trevena_Inc subject Category:Privately_held_companies_based_in_Pennsylvania.
- Trevena_Inc hypernym Leader.
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- Trevena_Inc comment "Trevena Inc a clinical stage biopharmaceutical company, headquartered in King of Prussia, PA, and is the leader in the discovery and development of G-protein coupled receptors (GPCR) biased ligands. Trevena was founded with technology licensed from Duke University, which originated in the labs of company founders Robert Lefkowitz winner of the 2012 Nobel Prize in Chemistry and Howard Rockman.".
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- Trevena_Inc depiction Trevena-logo.gif.
- Trevena_Inc homepage www.trevenainc.com.
- Trevena_Inc isPrimaryTopicOf Trevena_Inc.
- Trevena_Inc name "Trevena Inc".