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- Toll-Interleukin_receptor abstract "The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, interleukin-1 receptor, Toll receptor and many plant R proteins. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (UniProt Q99836) and TOLLIP (Toll interacting protein, UniProt Q9H0E2). In turn, these associate with various kinases to set off signaling cascades. In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (TLRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase. MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see IPR000488). Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense. As MyD88, these proteins are cytoplasmic.Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements.".
- Toll-Interleukin_receptor symbol "TIR".
- Toll-Interleukin_receptor thumbnail PDB_2js7_EBI.png?width=300.
- Toll-Interleukin_receptor wikiPageID "28952360".
- Toll-Interleukin_receptor wikiPageLength "5047".
- Toll-Interleukin_receptor wikiPageOutDegree "38".
- Toll-Interleukin_receptor wikiPageRevisionID "638368878".
- Toll-Interleukin_receptor wikiPageWikiLink Category:Protein_domains.
- Toll-Interleukin_receptor wikiPageWikiLink Category:Protein_families.
- Toll-Interleukin_receptor wikiPageWikiLink Category:Single-pass_transmembrane_proteins.
- Toll-Interleukin_receptor wikiPageWikiLink Drosophila_melanogaster.
- Toll-Interleukin_receptor wikiPageWikiLink IL18R1.
- Toll-Interleukin_receptor wikiPageWikiLink IL18RAP.
- Toll-Interleukin_receptor wikiPageWikiLink IL1R1.
- Toll-Interleukin_receptor wikiPageWikiLink IL1RAP.
- Toll-Interleukin_receptor wikiPageWikiLink IL1RAPL1.
- Toll-Interleukin_receptor wikiPageWikiLink IL1RAPL2.
- Toll-Interleukin_receptor wikiPageWikiLink IL1RL1.
- Toll-Interleukin_receptor wikiPageWikiLink IL1RL2.
- Toll-Interleukin_receptor wikiPageWikiLink Interleukin-1_receptor.
- Toll-Interleukin_receptor wikiPageWikiLink Interleukin_1_receptor,_type_I.
- Toll-Interleukin_receptor wikiPageWikiLink Limb_development.
- Toll-Interleukin_receptor wikiPageWikiLink MYD88.
- Toll-Interleukin_receptor wikiPageWikiLink MyD88.
- Toll-Interleukin_receptor wikiPageWikiLink Protein_kinase.
- Toll-Interleukin_receptor wikiPageWikiLink R_gene.
- Toll-Interleukin_receptor wikiPageWikiLink SIGIRR.
- Toll-Interleukin_receptor wikiPageWikiLink TLR1.
- Toll-Interleukin_receptor wikiPageWikiLink TLR10.
- Toll-Interleukin_receptor wikiPageWikiLink TLR2.
- Toll-Interleukin_receptor wikiPageWikiLink TLR3.
- Toll-Interleukin_receptor wikiPageWikiLink TLR4.
- Toll-Interleukin_receptor wikiPageWikiLink TLR5.
- Toll-Interleukin_receptor wikiPageWikiLink TLR6.
- Toll-Interleukin_receptor wikiPageWikiLink TLR7.
- Toll-Interleukin_receptor wikiPageWikiLink TLR8.
- Toll-Interleukin_receptor wikiPageWikiLink TLR9.
- Toll-Interleukin_receptor wikiPageWikiLink TLR_1.
- Toll-Interleukin_receptor wikiPageWikiLink TOLLIP.
- Toll-Interleukin_receptor wikiPageWikiLink Toll-like_receptor.
- Toll-Interleukin_receptor wikiPageWikiLink Transcription_factor.
- Toll-Interleukin_receptor wikiPageWikiLink UniProt.
- Toll-Interleukin_receptor wikiPageWikiLinkText "TIR".
- Toll-Interleukin_receptor wikiPageWikiLinkText "Toll-Interleukin receptor".
- Toll-Interleukin_receptor caption "Structure of the MyD88 TIR domain".
- Toll-Interleukin_receptor hasPhotoCollection Toll-Interleukin_receptor.
- Toll-Interleukin_receptor interpro "IPR000157".
- Toll-Interleukin_receptor name "TIR domain".
- Toll-Interleukin_receptor pdb "B:407-558 A:643-781 A:643-781 E:643-781 A:639-775".
- Toll-Interleukin_receptor pfam "PF01582".
- Toll-Interleukin_receptor scop "1".
- Toll-Interleukin_receptor symbol "TIR".
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:InterPro.
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:InterPro_content.
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:Membrane-protein-stub.
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:Pfam_box.
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:Reflist.
- Toll-Interleukin_receptor wikiPageUsesTemplate Template:Uniprot.
- Toll-Interleukin_receptor subject Category:Protein_domains.
- Toll-Interleukin_receptor subject Category:Protein_families.
- Toll-Interleukin_receptor subject Category:Single-pass_transmembrane_proteins.
- Toll-Interleukin_receptor hypernym Intracellular.
- Toll-Interleukin_receptor type Biomolecule.
- Toll-Interleukin_receptor type Protein.
- Toll-Interleukin_receptor type Chemical.
- Toll-Interleukin_receptor type Domain.
- Toll-Interleukin_receptor type Thing.
- Toll-Interleukin_receptor type Q206229.
- Toll-Interleukin_receptor type Q8054.
- Toll-Interleukin_receptor comment "The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, interleukin-1 receptor, Toll receptor and many plant R proteins. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease.".
- Toll-Interleukin_receptor label "Toll-Interleukin receptor".
- Toll-Interleukin_receptor sameAs m.0dgrf1c.
- Toll-Interleukin_receptor sameAs Q7814304.
- Toll-Interleukin_receptor sameAs Q7814304.
- Toll-Interleukin_receptor wasDerivedFrom Toll-Interleukin_receptor?oldid=638368878.
- Toll-Interleukin_receptor depiction PDB_2js7_EBI.png.
- Toll-Interleukin_receptor isPrimaryTopicOf Toll-Interleukin_receptor.