Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Tofisopam> ?p ?o }
- Tofisopam abstract "Tofisopam (Emandaxin, Grandaxin, Sériel) is an anxiolytic that is marketed in several European countries. Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines (which are generally 1,4- or 1,5-substituted) however, tofisopam does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. While it may not be an anticonvulsant in and of itself, it has been shown to enhance the anticonvulsant action of classical 1,4-benzodiazepines such as diazepam (but not sodium valproate, carbamazepine, phenobarbital, or phenytoin). Tofisopam is indicated for the treatment of anxiety and alcohol withdrawal, and is prescribed in a dosage of 50–300 mg per day divided into three doses. Peak plasma levels are attained two hours after an oral dose. Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines, but is still recommended to be prescribed for a maximum of 12 weeks.Tofisopam is not approved for sale in the United States or Canada. However, Vela Pharmaceuticals of New Jersey is developing the D-enantiomer (dextofisopam) as a treatment for irritable bowel syndrome, with moderate efficacy demonstrated in clinical trials so far.Tofisopam is also claimed to be a PDE10A inhibitor, which may provide an alternative mechanism of action for its various therapeutic effects, and this action has been proposed to make tofisopam potentially useful as a treatment for schizophrenia.Tofisopam has been shown to act as an inhibitor of the liver enzyme CYP3A4, and this could potentially cause dangerous drug interactions with other medications metabolised by this enzyme, although the clinical significance of these findings remains unclear.".
- Tofisopam atcPrefix "N05".
- Tofisopam atcSuffix "BA23".
- Tofisopam casNumber "22345-47-7".
- Tofisopam drugbank "DB08811".
- Tofisopam fdaUniiCode "UZC80HAU42".
- Tofisopam iupacName "1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine".
- Tofisopam pubchem "5502".
- Tofisopam thumbnail Tofisopam_structure.svg?width=300.
- Tofisopam wikiPageExternalLink pim686.htm.
- Tofisopam wikiPageID "4145371".
- Tofisopam wikiPageLength "6958".
- Tofisopam wikiPageOutDegree "26".
- Tofisopam wikiPageRevisionID "648330080".
- Tofisopam wikiPageWikiLink Alcohol_withdrawal.
- Tofisopam wikiPageWikiLink Alcohol_withdrawal_syndrome.
- Tofisopam wikiPageWikiLink Amnesia.
- Tofisopam wikiPageWikiLink Anticonvulsant.
- Tofisopam wikiPageWikiLink Anxiety.
- Tofisopam wikiPageWikiLink Anxiolytic.
- Tofisopam wikiPageWikiLink Benzodiazepine.
- Tofisopam wikiPageWikiLink CYP3A4.
- Tofisopam wikiPageWikiLink Carbamazepine.
- Tofisopam wikiPageWikiLink Category:Anxiolytics.
- Tofisopam wikiPageWikiLink Category:Benzodiazepines.
- Tofisopam wikiPageWikiLink Category:Phenol_ethers.
- Tofisopam wikiPageWikiLink Category:Phosphodiesterase_inhibitors.
- Tofisopam wikiPageWikiLink Enantiomer.
- Tofisopam wikiPageWikiLink Europe.
- Tofisopam wikiPageWikiLink Irritable_bowel_syndrome.
- Tofisopam wikiPageWikiLink Kidney.
- Tofisopam wikiPageWikiLink Liver.
- Tofisopam wikiPageWikiLink Motor_skill.
- Tofisopam wikiPageWikiLink Muscle_relaxant.
- Tofisopam wikiPageWikiLink Phenobarbital.
- Tofisopam wikiPageWikiLink Phenytoin.
- Tofisopam wikiPageWikiLink Phosphodiesterase_inhibitor.
- Tofisopam wikiPageWikiLink Schizophrenia.
- Tofisopam wikiPageWikiLink Sedative.
- Tofisopam wikiPageWikiLink Sodium_valproate.
- Tofisopam wikiPageWikiLink Valproate.
- Tofisopam wikiPageWikiLink Vela_Pharmaceuticals.
- Tofisopam wikiPageWikiLinkText "Tofisopam".
- Tofisopam wikiPageWikiLinkText "tofisopam".
- Tofisopam atcPrefix "N05".
- Tofisopam atcSuffix "BA23".
- Tofisopam bioavailability "?".
- Tofisopam c "22".
- Tofisopam casNumber "22345".
- Tofisopam chembl "404216".
- Tofisopam chemspiderid "5301".
- Tofisopam drugbank "DB08811".
- Tofisopam eliminationHalfLife "-28800.0".
- Tofisopam excretion Kidney.
- Tofisopam h "26".
- Tofisopam hasPhotoCollection Tofisopam.
- Tofisopam image "Tofisopam3d.png".
- Tofisopam inchi "1".
- Tofisopam inchikey "RUJBDQSFYCKFAA-UHFFFAOYAV".
- Tofisopam iupacName "1".
- Tofisopam kegg "D01254".
- Tofisopam legalStatus "?".
- Tofisopam metabolism Liver.
- Tofisopam molecularWeight "382.5".
- Tofisopam n "2".
- Tofisopam o "4".
- Tofisopam pregnancyCategory "?".
- Tofisopam pubchem "5502".
- Tofisopam routesOfAdministration "Oral".
- Tofisopam smiles "OC".
- Tofisopam stdinchi "1".
- Tofisopam stdinchikey "RUJBDQSFYCKFAA-UHFFFAOYSA-N".
- Tofisopam synonyms "(6--2-ethyl-9,10-dimethoxy-3-methyl-4,5-diazabicyclo[5.4.0]undeca-3,5,7,9,11-pentaene)".
- Tofisopam unii "UZC80HAU42".
- Tofisopam verifiedrevid "443236809".
- Tofisopam width "180".
- Tofisopam wikiPageUsesTemplate Template:Anxiolytics.
- Tofisopam wikiPageUsesTemplate Template:Benzodiazepines.
- Tofisopam wikiPageUsesTemplate Template:Drugbox.
- Tofisopam wikiPageUsesTemplate Template:Phosphodiesterase_inhibitors.
- Tofisopam wikiPageUsesTemplate Template:Reflist.
- Tofisopam subject Category:Anxiolytics.
- Tofisopam subject Category:Benzodiazepines.
- Tofisopam subject Category:Phenol_ethers.
- Tofisopam subject Category:Phosphodiesterase_inhibitors.
- Tofisopam type Article.
- Tofisopam type ChemicalSubstance.
- Tofisopam type Drug.
- Tofisopam type Anticonvulsant.
- Tofisopam type Article.
- Tofisopam type Benzodiazepine.
- Tofisopam type Drug.
- Tofisopam type Ether.
- Tofisopam type Heterocycle.
- Tofisopam type Inhibitor.
- Tofisopam type ChemicalObject.
- Tofisopam type Thing.
- Tofisopam type Q8386.
- Tofisopam comment "Tofisopam (Emandaxin, Grandaxin, Sériel) is an anxiolytic that is marketed in several European countries. Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines (which are generally 1,4- or 1,5-substituted) however, tofisopam does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties.".
- Tofisopam label "Tofisopam".