Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/The_cGAS_–_STING_cytosolic_DNA_sensing_pathway> ?p ?o }
Showing triples 1 to 66 of
66
with 100 triples per page.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway abstract "The cGAS – STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes. DNA is normally found in the nucleus of the cell. Localization of DNA to the cytosol is associated with tumorigenesis or viral infection. The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response.Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers dimerization of AMP and GMP to form cyclic GMP-AMP (cGAMP). cGAMP binds to Stimulator of Interferon Genes (STING) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses.The innate immune system relies on germline encoded pattern recognition receptors (PRRs) to recognize distinct PAMPs. Upon recognition of a PAMP, PRRs generate signal cascades leading to transcription of genes associated with the immune response. Because all pathogens utilize nucleic acid to propagate, DNA and RNA can be recognized by PRRs to trigger immune activation. In normal cells, nucleic acid is confined to the nucleus or mitochondria. The presence of nucleic acid in the cytosol is indicative of cellular damage or infection and leads to activation genes associated with the immune response. One way cytosolic nucleic acid is sensed is via the cGAS/STING pathway. Cytosolic DNA is recognized by cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition cGAS dimerizes and stimulates the formation of cyclic-GMP-AMP (cGAMP). cGAMP then binds directly to stimulator of interferon genes (STING) which triggers phosphorylation/activation of the transcription factor IRF3 via TBK1. IRF3 is able to enter the nucleus to promote transcription of inflammatory genes, such as IFN-β.".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageID "47190749".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageLength "18081".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageOutDegree "56".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageRevisionID "671468442".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Adenosine_triphosphate.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Affinity_chromatography.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Aicardi–Goutières_syndrome.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Amino_acid.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink CCL2.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink CCL20.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Carcinogenesis.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Category:DNA.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Category:Immune_system.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Cell_nucleus.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Chemokine.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Cross-link.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Cyclic_GMP-AMP_synthase.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Cyclic_guanosine_monophosphate–adenosine_monophosphate.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Cytosol.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink DNA.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Dendritic_cell.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Endoplasmic_reticulum.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Fibroblast.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Germline.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Guanosine_triphosphate.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink IRF3.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Innate_immune_system.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Interferon_type_I.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Interleukin_2.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink IκB_kinase.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink MHC_class_II.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Mitochondrion.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink NF-κB.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink NKG2D.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Natural_killer_cell.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Nucleic_acid.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Nucleotidyltransferase.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Ovalbumin.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Pathogen-associated_molecular_pattern.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Pattern_recognition_receptor.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Phagocytosis.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink RNA.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink STAT6.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Sendai_virus.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Stimulator_of_interferon_genes.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Subtypes_of_hiv.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink TANK-binding_kinase_1.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink T_cell.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Transcription_(genetics).
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Transcription_factor.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Transfection.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Vesicular_stomatitis_virus.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink Virus.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink File:CGAS_bound_to_dsDNA.png.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLink File:STING_bound_to_cGAMP.png.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageWikiLinkText "cytosolic DNA sensor".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway hasPhotoCollection The_cGAS_–_STING_cytosolic_DNA_sensing_pathway.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageUsesTemplate Template:Orphan.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wikiPageUsesTemplate Template:Reflist.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway subject Category:DNA.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway subject Category:Immune_system.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway comment "The cGAS – STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes. DNA is normally found in the nucleus of the cell. Localization of DNA to the cytosol is associated with tumorigenesis or viral infection.".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway label "The cGAS – STING cytosolic DNA sensing pathway".
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway wasDerivedFrom The_cGAS_–_STING_cytosolic_DNA_sensing_pathway?oldid=671468442.
- The_cGAS_–_STING_cytosolic_DNA_sensing_pathway isPrimaryTopicOf The_cGAS_–_STING_cytosolic_DNA_sensing_pathway.