Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Tat_(HIV)> ?p ?o }
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- Tat_(HIV) abstract "In molecular biology, tat is a protein that is encoded for by the tat gene in HIV-1. Tat is a regulatory protein that drastically enhances the efficiency of viral transcription.Tat stands for "Trans-Activator of Transcription."The protein consists of between 86 and 101 amino acids depending on the subtype. Tat vastly increases the level of transcription of the HIV dsDNA. Before Tat is present, a small number of RNA transcripts will be made, which allow the Tat protein to be produced. Tat then binds to cellular factors and mediates their phosphorylation, resulting in increased transcription of all HIV genes, providing a positive feedback cycle. This in turn allows HIV to have an explosive response once a threshold amount of Tat is produced, a useful tool for defeating the body's response.Tat also appears to play a more direct role in the HIV disease process. The protein is released by infected cells in culture, and is found in the blood of HIV-1 infected patients.It can be absorbed by cells that are not infected with HIV, and can act directly as a toxin producing cell death via apoptosis in uninfected "bystander" T cells, assisting in progression toward AIDS.By antagonizing the CXCR4 receptor, Tat also appears to selectively encourage the reproduction of less virulent M-tropic (macrophage-tropic) strains of HIV (which use the CCR5 receptor) early in the course of infection, allowing the more rapidly pathogenic T-tropic (T-cell-tropic) strains (which use the CXCR4 receptor) to emerge later after mutating from M-tropic strains.".
- Tat_(HIV) symbol "Tat".
- Tat_(HIV) thumbnail PDB_1biv_EBI.jpg?width=300.
- Tat_(HIV) wikiPageID "20938024".
- Tat_(HIV) wikiPageLength "12870".
- Tat_(HIV) wikiPageOutDegree "47".
- Tat_(HIV) wikiPageRevisionID "683143903".
- Tat_(HIV) wikiPageWikiLink AIDS.
- Tat_(HIV) wikiPageWikiLink Alpha_helix.
- Tat_(HIV) wikiPageWikiLink Amino_acid.
- Tat_(HIV) wikiPageWikiLink Amino_acids.
- Tat_(HIV) wikiPageWikiLink Apoptosis.
- Tat_(HIV) wikiPageWikiLink Binding_site.
- Tat_(HIV) wikiPageWikiLink CCR5.
- Tat_(HIV) wikiPageWikiLink CDK9.
- Tat_(HIV) wikiPageWikiLink CXCR4.
- Tat_(HIV) wikiPageWikiLink AIDS.
- Tat_(HIV) wikiPageWikiLink Category:Viral_proteins.
- Tat_(HIV) wikiPageWikiLink Cell-penetrating_peptide.
- Tat_(HIV) wikiPageWikiLink Cell_membrane.
- Tat_(HIV) wikiPageWikiLink Cyclin-dependent_kinase_9.
- Tat_(HIV) wikiPageWikiLink Cyclin_T1.
- Tat_(HIV) wikiPageWikiLink Directionality_(molecular_biology).
- Tat_(HIV) wikiPageWikiLink Domain_(biology).
- Tat_(HIV) wikiPageWikiLink Gene.
- Tat_(HIV) wikiPageWikiLink Genome.
- Tat_(HIV) wikiPageWikiLink HIV.
- Tat_(HIV) wikiPageWikiLink AIDS.
- Tat_(HIV) wikiPageWikiLink HIV_tropism.
- Tat_(HIV) wikiPageWikiLink In_vitro.
- Tat_(HIV) wikiPageWikiLink Lentivirus.
- Tat_(HIV) wikiPageWikiLink Macrophage.
- Tat_(HIV) wikiPageWikiLink Molecular_binding.
- Tat_(HIV) wikiPageWikiLink Molecular_biology.
- Tat_(HIV) wikiPageWikiLink Multiprotein_complex.
- Tat_(HIV) wikiPageWikiLink N-terminus.
- Tat_(HIV) wikiPageWikiLink Nuclear_localization_sequence.
- Tat_(HIV) wikiPageWikiLink P-TEFb.
- Tat_(HIV) wikiPageWikiLink Phosphorylation.
- Tat_(HIV) wikiPageWikiLink Positive_feedback.
- Tat_(HIV) wikiPageWikiLink Promoter_(genetics).
- Tat_(HIV) wikiPageWikiLink Protein.
- Tat_(HIV) wikiPageWikiLink Protein_domain.
- Tat_(HIV) wikiPageWikiLink Protein–protein_interaction.
- Tat_(HIV) wikiPageWikiLink RNA_polymerase_II.
- Tat_(HIV) wikiPageWikiLink Regulation_of_gene_expression.
- Tat_(HIV) wikiPageWikiLink Regulatory_protein.
- Tat_(HIV) wikiPageWikiLink Sequence_(biology).
- Tat_(HIV) wikiPageWikiLink Stem-loop.
- Tat_(HIV) wikiPageWikiLink T_cell.
- Tat_(HIV) wikiPageWikiLink T_helper_cell.
- Tat_(HIV) wikiPageWikiLink Toxin.
- Tat_(HIV) wikiPageWikiLink Transcription_(genetics).
- Tat_(HIV) wikiPageWikiLink Transduction_(genetics).
- Tat_(HIV) wikiPageWikiLinkText "''Trans''-activator of transcription protein".
- Tat_(HIV) wikiPageWikiLinkText "HIV Tat".
- Tat_(HIV) wikiPageWikiLinkText "TAT".
- Tat_(HIV) wikiPageWikiLinkText "Tat (HIV)".
- Tat_(HIV) wikiPageWikiLinkText "Tat protein".
- Tat_(HIV) wikiPageWikiLinkText "Tat".
- Tat_(HIV) wikiPageWikiLinkText "tat protein".
- Tat_(HIV) wikiPageWikiLinkText "tat".
- Tat_(HIV) caption "Bovine immunodeficiency virus tat–tar complex, nmr, 5 structures".
- Tat_(HIV) hasPhotoCollection Tat_(HIV).
- Tat_(HIV) interpro "IPR001831".
- Tat_(HIV) name "Tat".
- Tat_(HIV) pfam "PF00539".
- Tat_(HIV) prosite "PDOC00836".
- Tat_(HIV) scop "1".
- Tat_(HIV) symbol "Tat".
- Tat_(HIV) tcdb "2".
- Tat_(HIV) wikiPageUsesTemplate Template:As_of.
- Tat_(HIV) wikiPageUsesTemplate Template:Infobox_protein_family.
- Tat_(HIV) wikiPageUsesTemplate Template:Reflist.
- Tat_(HIV) wikiPageUsesTemplate Template:Viral_proteins.
- Tat_(HIV) subject AIDS.
- Tat_(HIV) subject Category:Viral_proteins.
- Tat_(HIV) hypernym Protein.
- Tat_(HIV) type Biomolecule.
- Tat_(HIV) type Protein.
- Tat_(HIV) type Thing.
- Tat_(HIV) type Q206229.
- Tat_(HIV) type Q8054.
- Tat_(HIV) comment "In molecular biology, tat is a protein that is encoded for by the tat gene in HIV-1. Tat is a regulatory protein that drastically enhances the efficiency of viral transcription.Tat stands for "Trans-Activator of Transcription."The protein consists of between 86 and 101 amino acids depending on the subtype. Tat vastly increases the level of transcription of the HIV dsDNA. Before Tat is present, a small number of RNA transcripts will be made, which allow the Tat protein to be produced.".
- Tat_(HIV) label "Tat (HIV)".
- Tat_(HIV) sameAs Tat.
- Tat_(HIV) sameAs Tat_(proteina).
- Tat_(HIV) sameAs m.05b0nyf.
- Tat_(HIV) sameAs Q3981457.
- Tat_(HIV) sameAs Q3981457.
- Tat_(HIV) wasDerivedFrom Tat_(HIV)?oldid=683143903.
- Tat_(HIV) depiction PDB_1biv_EBI.jpg.
- Tat_(HIV) isPrimaryTopicOf Tat_(HIV).