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- TRPC abstract "TRPC is a family of transient receptor potential cation channels in animals.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. In terms of structure, this family possesses a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.The predominant TRPC channels in the mammalian brain are the TRPC 1,4 and 5 and they are densely expressed in corticolimbic brain regions, like the hippocampus, prefrontal cortex and lateral septum. The TRPC channels 1,4 and 5 functional group is activated by the metabotropic glutamate receptor group 1 agonist DHPG.In general, TRPC channels can be activated by phospholipase C stimulation, with some members also activated by diacylglycerol. There is one at least one report that TRPC1 is also activated by stretching of the membrane and TRPC5 channels are activated by extracellular reduced thioredoxin.It has long been proposed that TRPC channels underlie the store-operated channels (SOC) observed in many cell types. These channels open due to the depletion of intracellular calcium stores. Two other proteins, stromal interaction molecules (STIMs) and the ORAIs, however, have more recently been implicated in this process. STIM1 and TRPC1 can coassemble, complicating the understanding of this phenomenon.TRPC6 has been implicated in late onset Alzheimer's disease.Role of TRPC Channels in Cardiomyopathies Research on the role of TRPC channels in cardiomyopathies is still in progress. An upregulation of TRPC1, TRPC3, and TRPC6 genes are seen in heart disease states including fibroblast formation and cardiovascular disease. The TRPC channels are suspected of responding to an overload of hormonal and mechanical stimulation in cardiovascular disease, contributing to pathological remodelling of the heart.TRPC1 channels are activated by receptors coupled to phospholipase C (PLC), mechanical stimulation, and depletion of intracellular calcium stores. TRPC1 channels are found on cardiomyocytes, smooth muscle, and endothelial cells. Upon stimulation of these channels in cardiovascular disease, there is an increase in hypertension and cardiac hypertrophy. TRPC1 channels mediate smooth muscle proliferation in the presence of pathological stimuli which contributes to hypertension. Mice with myocardial hypertrophy exhibit increased expression of TRPC1. The deletion of the TRPC1 gene in these mice resulted in reduced hypertrophy upon stimulation with hypertrophic stimuli, inferring that TRPC1 has a role in the progression of cardiac hypertrophy.TRPC3 and TRPC6 channels are activated by PLC stimulation and diacylglycerol (DAG) production. Both these TRPC channel types play a role in cardiac hypertrophy and vascular disease like TRPC1. In addition, TRPC3 is upregulated in the atria of patients with atrial fibrillation (AF). TRPC3 regulates angiotensin II-induced cardiac hypertrophy which contributes to the formation of fibroblasts. Accumulation of fibroblasts in the heart can manifest into AF. Experiments blocking TRPC3 show a decrease in fibroblast formation and reduced AF susceptibility.TRPC1, TRPC3, and TRPC6 channels are all involved in cardiac hypertrophy. The mechanism of how TRPC channels promote cardiac hypertrophy is through activation of the calcineurin pathway and the downstream transcription factor nuclear factor of activated T-cells (NFAT).Pathological stress or hypertrophic agonists will trigger G-protein coupled receptors (GPCRs) and activates PLC to form DAG and inositol triphosphate (IP3).IP3 promotes the release of internal calcium stores and the influx of calcium via TRPC. When intracellular calcium reaches a threshold, it will activate the calcineurin /NFAT pathway. DAG activates the calcineurin/NFAT pathway directly.NFAT translocate into the nucleus and induce gene transcription of more TRPC genes. This creates a positive feedback loop, leading to a state of hypertrophic gene expression and thus, cardiac growth and remodelling of the heart.TRPC channel’s involvement in well studied signaling pathways and significance in gene impact on human diseases make it a potential target for drug therapy.TRPC has been shown to potentiate inhibition in the olfactory bulb circuit, providing a mechanism for improving olfactory abilities".
- TRPC wikiPageExternalLink FamilyMenuForward?familyId=12.
- TRPC wikiPageExternalLink www.trpchannel.org.
- TRPC wikiPageID "9725350".
- TRPC wikiPageLength "10048".
- TRPC wikiPageOutDegree "40".
- TRPC wikiPageRevisionID "679094325".
- TRPC wikiPageWikiLink Angiotensin.
- TRPC wikiPageWikiLink Angiotensin_II.
- TRPC wikiPageWikiLink Ankyrin.
- TRPC wikiPageWikiLink Atrial_fibrillation.
- TRPC wikiPageWikiLink Calcineurin.
- TRPC wikiPageWikiLink Cardiac_muscle_cell.
- TRPC wikiPageWikiLink Cardiomyocytes.
- TRPC wikiPageWikiLink Cardiomyopathies.
- TRPC wikiPageWikiLink Cardiomyopathy.
- TRPC wikiPageWikiLink Cardiovascular_disease.
- TRPC wikiPageWikiLink Category:Ion_channels.
- TRPC wikiPageWikiLink Category:Membrane_biology.
- TRPC wikiPageWikiLink Diacylglycerol.
- TRPC wikiPageWikiLink Diglyceride.
- TRPC wikiPageWikiLink Drug_therapy.
- TRPC wikiPageWikiLink Endothelial_cells.
- TRPC wikiPageWikiLink Endothelium.
- TRPC wikiPageWikiLink Fibroblast.
- TRPC wikiPageWikiLink Fibroblasts.
- TRPC wikiPageWikiLink G-protein_coupled_receptors.
- TRPC wikiPageWikiLink G_protein–coupled_receptor.
- TRPC wikiPageWikiLink Hypertension.
- TRPC wikiPageWikiLink Hypertrophy.
- TRPC wikiPageWikiLink Inositol_triphosphate.
- TRPC wikiPageWikiLink Inositol_trisphosphate.
- TRPC wikiPageWikiLink Ion_channel.
- TRPC wikiPageWikiLink NFAT.
- TRPC wikiPageWikiLink Nuclear_factor_of_activated_T-cells.
- TRPC wikiPageWikiLink Pharmacotherapy.
- TRPC wikiPageWikiLink Phospholipase_C.
- TRPC wikiPageWikiLink Positive_feedback.
- TRPC wikiPageWikiLink Protein_targeting.
- TRPC wikiPageWikiLink Protein_translocation.
- TRPC wikiPageWikiLink STIM1.
- TRPC wikiPageWikiLink Smooth_muscle.
- TRPC wikiPageWikiLink Smooth_muscle_tissue.
- TRPC wikiPageWikiLink TRPC1.
- TRPC wikiPageWikiLink TRPC2.
- TRPC wikiPageWikiLink TRPC3.
- TRPC wikiPageWikiLink TRPC4.
- TRPC wikiPageWikiLink TRPC5.
- TRPC wikiPageWikiLink TRPC6.
- TRPC wikiPageWikiLink TRPC7.
- TRPC wikiPageWikiLink Thioredoxin.
- TRPC wikiPageWikiLink Transient_receptor_potential_channel.
- TRPC wikiPageWikiLinkText "TRPC".
- TRPC wikiPageWikiLinkText "transient receptor potential canonical (TRPC) family channels".
- TRPC wikiPageWikiLinkText "transient receptor potential canonical".
- TRPC hasPhotoCollection TRPC.
- TRPC wikiPageUsesTemplate Template:Cite_web.
- TRPC wikiPageUsesTemplate Template:Ion_channels.
- TRPC wikiPageUsesTemplate Template:MeshName.
- TRPC wikiPageUsesTemplate Template:Reflist.
- TRPC subject Category:Ion_channels.
- TRPC subject Category:Membrane_biology.
- TRPC hypernym Family.
- TRPC type Biophysic.
- TRPC type Channel.
- TRPC comment "TRPC is a family of transient receptor potential cation channels in animals.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. In terms of structure, this family possesses a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus.".
- TRPC label "TRPC".
- TRPC sameAs m.02pq8zk.
- TRPC sameAs Q7671459.
- TRPC sameAs Q7671459.
- TRPC wasDerivedFrom TRPC?oldid=679094325.
- TRPC isPrimaryTopicOf TRPC.