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- TOM_complex abstract "The TIM/TOM complex is a process in cellular biochemistry which describes the translocation of proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA.The vast majority of proteins destined for the mitochondria are encoded in the nucleus and synthesized in the cytoplasm. These are tagged by an N-terminal signal sequence. Following transport through the cytosol from the nucleus, the signal sequence is recognized by a receptor protein in the transporter outer membrane (TOM) complex. The signal sequence and adjacent portions of the polypeptide chain are inserted in the TOM complex, then begin interaction with a transporter inner membrane (TIM) complex, which are hypothesized to be transiently linked at sites of close contact between the two membranes. The signal sequence is then translocated into the matrix in a process that requires an electrochemical hydrogen ion gradient across the inner membrane. Mitochondrial Hsp70 binds to regions of the polypeptide chain and maintains it in an unfolded state as it moves into the matrix.".
- TOM_complex thumbnail Mitochondrial_dna_organization_cartoon.jpg?width=300.
- TOM_complex wikiPageExternalLink Figure-Pfanner2006.gif.
- TOM_complex wikiPageExternalLink S0167488901001471.
- TOM_complex wikiPageID "7407236".
- TOM_complex wikiPageLength "2576".
- TOM_complex wikiPageOutDegree "15".
- TOM_complex wikiPageRevisionID "682439282".
- TOM_complex wikiPageWikiLink Biochemistry.
- TOM_complex wikiPageWikiLink Category:Mitochondria.
- TOM_complex wikiPageWikiLink Category:Transmembrane_proteins.
- TOM_complex wikiPageWikiLink Category:Transport_proteins.
- TOM_complex wikiPageWikiLink Cell_nucleus.
- TOM_complex wikiPageWikiLink Cytosol.
- TOM_complex wikiPageWikiLink DNA.
- TOM_complex wikiPageWikiLink Hsp70.
- TOM_complex wikiPageWikiLink Mitochondrial_DNA.
- TOM_complex wikiPageWikiLink Mitochondrion.
- TOM_complex wikiPageWikiLink Oxidative_phosphorylation.
- TOM_complex wikiPageWikiLink Peptide.
- TOM_complex wikiPageWikiLink Polypeptide.
- TOM_complex wikiPageWikiLink Protein.
- TOM_complex wikiPageWikiLink Proteins.
- TOM_complex wikiPageWikiLink TOC_complex.
- TOM_complex wikiPageWikiLink File:Mitochondrial_dna_organization_cartoon.jpg.
- TOM_complex wikiPageWikiLinkText "TIM/TOM complex".
- TOM_complex wikiPageWikiLinkText "TOM and TIM".
- TOM_complex wikiPageWikiLinkText "TOM/TIM Complex".
- TOM_complex hasPhotoCollection TOM_complex.
- TOM_complex wikiPageUsesTemplate Template:Biochemistry-stub.
- TOM_complex wikiPageUsesTemplate Template:Reflist.
- TOM_complex subject Category:Mitochondria.
- TOM_complex subject Category:Transmembrane_proteins.
- TOM_complex subject Category:Transport_proteins.
- TOM_complex hypernym Process.
- TOM_complex type Election.
- TOM_complex comment "The TIM/TOM complex is a process in cellular biochemistry which describes the translocation of proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. Only 13 proteins necessary for a mitochondrion are actually coded in mitochondrial DNA.The vast majority of proteins destined for the mitochondria are encoded in the nucleus and synthesized in the cytoplasm. These are tagged by an N-terminal signal sequence.".
- TOM_complex label "TIM/TOM complex".
- TOM_complex sameAs TOM_komplex.
- TOM_complex sameAs TOM.
- TOM_complex sameAs m.0260rdm.
- TOM_complex sameAs TOM-komplex.
- TOM_complex sameAs Q3504639.
- TOM_complex sameAs Q3504639.
- TOM_complex wasDerivedFrom TOM_complex?oldid=682439282.
- TOM_complex depiction Mitochondrial_dna_organization_cartoon.jpg.
- TOM_complex isPrimaryTopicOf TOM_complex.