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- TBX20 abstract "TBX20 (gene)is a member of the T-box family that encodes the transcription factor TBX20. Studies in mouse, human and fruitfly have shown that this gene is essential for early heart development, adult heart function and yolk sac vasculature remodeling and has been associated with congenital heart diseases. Tbx20 was also shown to be required for migration of hindbrain motor neurons and in facial neurons was proposed to be a positive regulator of the non-canonical Wnt signaling pathway. Tbx20 is a transcription factor that is essential for proper heart development in a growing fetus. Any mutations in this gene can result in various forms of congenital heart disease. One of the more serious examples is the presence of a septal defect. The interatrial septum is a piece of tissue that separates the left and right atria of the heart, which contain oxygenated and deoxygenated blood, respectively. In Tbx20 mutants, this divider does not form and results in deoxygenated blood flowing into the left atrium then left ventricle, which ships the blood to the organs and muscles. Since deoxygenated blood should not be delivered to the tissues, the result is cyanosis, or a bluish skin discoloration stemming from low oxygen concentration. Proper function of Tbx20 is essential because it controls other genes that regulate cardiomyocyte proliferation, such as Tbx2 and N-myc1. Cardiomyocytes are the basis for the correct architectural scheme of the heart, and if defects arise in these structures, proper heart development is likely unattainable.".
- TBX20 entrezgene "57057".
- TBX20 wikiPageExternalLink Q9ES03.
- TBX20 wikiPageExternalLink Q9UMR3.
- TBX20 wikiPageExternalLink 57057.html.
- TBX20 wikiPageID "32683007".
- TBX20 wikiPageLength "8693".
- TBX20 wikiPageOutDegree "37".
- TBX20 wikiPageRevisionID "625123927".
- TBX20 wikiPageWikiLink Atrium_(heart).
- TBX20 wikiPageWikiLink Cardiac_muscle.
- TBX20 wikiPageWikiLink Cardiac_muscle_cell.
- TBX20 wikiPageWikiLink Cardiomyocyte.
- TBX20 wikiPageWikiLink Category:Transcription_factors.
- TBX20 wikiPageWikiLink Chromatin_immunoprecipitation.
- TBX20 wikiPageWikiLink Circulatory_system.
- TBX20 wikiPageWikiLink Congenital_heart_defect.
- TBX20 wikiPageWikiLink Congenital_heart_disease.
- TBX20 wikiPageWikiLink Cyanosis.
- TBX20 wikiPageWikiLink Depolarization.
- TBX20 wikiPageWikiLink Drosophila.
- TBX20 wikiPageWikiLink Embryo.
- TBX20 wikiPageWikiLink Embryos.
- TBX20 wikiPageWikiLink Fetus.
- TBX20 wikiPageWikiLink Fluorescent_protein.
- TBX20 wikiPageWikiLink GATA4.
- TBX20 wikiPageWikiLink Gene.
- TBX20 wikiPageWikiLink Genes.
- TBX20 wikiPageWikiLink Genome.
- TBX20 wikiPageWikiLink Green_fluorescent_protein.
- TBX20 wikiPageWikiLink Hindbrain.
- TBX20 wikiPageWikiLink Homeobox_protein_Nkx-2.5.
- TBX20 wikiPageWikiLink Homolog.
- TBX20 wikiPageWikiLink Homology_(biology).
- TBX20 wikiPageWikiLink Homozygous.
- TBX20 wikiPageWikiLink Hypoplasia.
- TBX20 wikiPageWikiLink Hypoplastic.
- TBX20 wikiPageWikiLink Interatrial_septum.
- TBX20 wikiPageWikiLink Knockout_mouse.
- TBX20 wikiPageWikiLink Left_atrioventricular_opening.
- TBX20 wikiPageWikiLink Left_atrioventricular_orifice.
- TBX20 wikiPageWikiLink Left_ventricle.
- TBX20 wikiPageWikiLink Motor_neuron.
- TBX20 wikiPageWikiLink Motor_neurons.
- TBX20 wikiPageWikiLink Myocardium.
- TBX20 wikiPageWikiLink Myofibril.
- TBX20 wikiPageWikiLink Myofibrillar.
- TBX20 wikiPageWikiLink NKX2-5.
- TBX20 wikiPageWikiLink Neuromancer.
- TBX20 wikiPageWikiLink Oxygen_saturation_(medicine).
- TBX20 wikiPageWikiLink Oxygenation_(medicine).
- TBX20 wikiPageWikiLink Septal_defect.
- TBX20 wikiPageWikiLink T-box.
- TBX20 wikiPageWikiLink Transcription_factor.
- TBX20 wikiPageWikiLink Vasculature.
- TBX20 wikiPageWikiLink Ventricle_(heart).
- TBX20 wikiPageWikiLink Wnt_signaling_pathway.
- TBX20 wikiPageWikiLink Yolk_sac.
- TBX20 wikiPageWikiLink Zygosity.
- TBX20 wikiPageWikiLinkText "TBX20".
- TBX20 hasPhotoCollection TBX20.
- TBX20 wikiPageUsesTemplate Template:PBB.
- TBX20 wikiPageUsesTemplate Template:Reflist.
- TBX20 subject Category:Transcription_factors.
- TBX20 hypernym Member.
- TBX20 type Biomolecule.
- TBX20 type Person.
- TBX20 type Protein.
- TBX20 type Factor.
- TBX20 type Thing.
- TBX20 type Q206229.
- TBX20 type Q8054.
- TBX20 comment "TBX20 (gene)is a member of the T-box family that encodes the transcription factor TBX20. Studies in mouse, human and fruitfly have shown that this gene is essential for early heart development, adult heart function and yolk sac vasculature remodeling and has been associated with congenital heart diseases. Tbx20 was also shown to be required for migration of hindbrain motor neurons and in facial neurons was proposed to be a positive regulator of the non-canonical Wnt signaling pathway.".
- TBX20 label "TBX20".
- TBX20 sameAs m.0h3nmsr.
- TBX20 sameAs Q7669574.
- TBX20 sameAs Q7669574.
- TBX20 wasDerivedFrom TBX20?oldid=625123927.
- TBX20 isPrimaryTopicOf TBX20.