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- T-HCA abstract "trans-4-Hydroxycrotonic acid, or T-HCA, is an agent used in scientific research to study the high-affinity GHB receptor. It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, where it acts as an agonist, but does not bind to the low-affinity GHB binding site, the GABAB receptor. Because of this, T-HCA does not produce sedation, and instead causes convulsions, which are thought to be caused by high-affinity GHB receptor activation-evoked increases in extracellular glutamate concentrations, with one notable area where this occurs being the hippocampus.".
- T-HCA atcPrefix "None".
- T-HCA casNumber "24587-49-3".
- T-HCA iupacName "(2E)-4-hydroxybut-2-enoic acid".
- T-HCA pubchem "6155526".
- T-HCA thumbnail Trans-4-hydroxycrotonic_acid.svg?width=300.
- T-HCA wikiPageID "20168884".
- T-HCA wikiPageLength "6319".
- T-HCA wikiPageOutDegree "20".
- T-HCA wikiPageRevisionID "674580972".
- T-HCA wikiPageWikiLink Active_metabolite.
- T-HCA wikiPageWikiLink Agonist.
- T-HCA wikiPageWikiLink Category:Carboxylic_acids.
- T-HCA wikiPageWikiLink Category:Convulsants.
- T-HCA wikiPageWikiLink Category:GHB_receptor_agonists.
- T-HCA wikiPageWikiLink Category:Neurotransmitters.
- T-HCA wikiPageWikiLink Central_nervous_system.
- T-HCA wikiPageWikiLink Convulsion.
- T-HCA wikiPageWikiLink Drug.
- T-HCA wikiPageWikiLink Endogenous.
- T-HCA wikiPageWikiLink Endogeny_(biology).
- T-HCA wikiPageWikiLink Extracellular.
- T-HCA wikiPageWikiLink GABAB_receptor.
- T-HCA wikiPageWikiLink GHB_receptor.
- T-HCA wikiPageWikiLink Gamma-Hydroxybutyric_acid.
- T-HCA wikiPageWikiLink Glutamate.
- T-HCA wikiPageWikiLink Glutamic_acid.
- T-HCA wikiPageWikiLink HOCPCA.
- T-HCA wikiPageWikiLink Hippocampus.
- T-HCA wikiPageWikiLink Scientific_method.
- T-HCA wikiPageWikiLink Scientific_research.
- T-HCA wikiPageWikiLink Sedation.
- T-HCA wikiPageWikiLink Structural_analog.
- T-HCA wikiPageWikiLink Γ-hydroxybutyric_acid.
- T-HCA wikiPageWikiLinkText "''trans''-Hydroxycrotonic acid".
- T-HCA wikiPageWikiLinkText "T-HCA".
- T-HCA atcPrefix "None".
- T-HCA c "4".
- T-HCA casNumber "24587".
- T-HCA chembl "507046".
- T-HCA chemspiderid "4825947".
- T-HCA h "6".
- T-HCA hasPhotoCollection T-HCA.
- T-HCA inchi "1".
- T-HCA inchikey "RMQJECWPWQIIPW-OWOJBTEDBE".
- T-HCA iupacName "-4".
- T-HCA molecularWeight "102.09".
- T-HCA o "3".
- T-HCA pubchem "6155526".
- T-HCA smiles "O=C\C=C\CO".
- T-HCA stdinchi "1".
- T-HCA stdinchikey "RMQJECWPWQIIPW-OWOJBTEDSA-N".
- T-HCA synonyms "(trans-4-hydroxycrotonic acid)".
- T-HCA verifiedfields "changed".
- T-HCA verifiedrevid "470475872".
- T-HCA watchedfields "changed".
- T-HCA width "200".
- T-HCA wikiPageUsesTemplate Template:Drugbox.
- T-HCA wikiPageUsesTemplate Template:GHBergics.
- T-HCA wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- T-HCA wikiPageUsesTemplate Template:Neurotransmitters.
- T-HCA wikiPageUsesTemplate Template:Reflist.
- T-HCA subject Category:Carboxylic_acids.
- T-HCA subject Category:Convulsants.
- T-HCA subject Category:GHB_receptor_agonists.
- T-HCA subject Category:Neurotransmitters.
- T-HCA hypernym Agent.
- T-HCA type Article.
- T-HCA type ChemicalSubstance.
- T-HCA type Drug.
- T-HCA type Group.
- T-HCA type Article.
- T-HCA type Chemical.
- T-HCA type Group.
- T-HCA type Modulator.
- T-HCA type ChemicalObject.
- T-HCA type Thing.
- T-HCA type Q8386.
- T-HCA comment "trans-4-Hydroxycrotonic acid, or T-HCA, is an agent used in scientific research to study the high-affinity GHB receptor. It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well.".
- T-HCA label "T-HCA".
- T-HCA sameAs m.04y6sdp.
- T-HCA sameAs T-HCA.
- T-HCA sameAs T-HCA.
- T-HCA sameAs Q7667802.
- T-HCA sameAs Q7667802.
- T-HCA wasDerivedFrom T-HCA?oldid=674580972.
- T-HCA depiction Trans-4-hydroxycrotonic_acid.svg.
- T-HCA isPrimaryTopicOf T-HCA.