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- Syntrophin abstract "The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in torpedo electric organ (originally called "58K protein"). Subsequently, alpha syntrophin was shown to be the predominant isoform in skeletal muscle where it is localized on the sarcolemma and enriched at the neuromuscular junction. The beta syntrophins and γ2 syntrophin are also present in skeletal muscle but also are in most other tissues. The expression of γ1 syntrophin is mostly confined to brain. The syntrophins are adapter proteins that use their multiple protein interaction domains (two pleckstrin homology domains and a PDZ domain) to localize a variety of signaling proteins (kinases, ion channels, water channels, nitric oxide synthase) to specific intracellular locations. α-Syntrophin binds to nNOS in the dystrophin associated glycoprotein complex in skeletal muscle cells. There it produces NO upon muscle contraction leading to dilation of the arteries in the local area.".
- Syntrophin wikiPageID "12783118".
- Syntrophin wikiPageLength "1631".
- Syntrophin wikiPageOutDegree "21".
- Syntrophin wikiPageRevisionID "554768473".
- Syntrophin wikiPageWikiLink Adapter_protein.
- Syntrophin wikiPageWikiLink Atomic_mass_unit.
- Syntrophin wikiPageWikiLink Becker_muscular_dystrophy.
- Syntrophin wikiPageWikiLink Beckers_muscular_dystrophy.
- Syntrophin wikiPageWikiLink Category:Proteins.
- Syntrophin wikiPageWikiLink Cell_signaling.
- Syntrophin wikiPageWikiLink Duchenne_muscular_dystrophy.
- Syntrophin wikiPageWikiLink Dystrophin.
- Syntrophin wikiPageWikiLink Gene.
- Syntrophin wikiPageWikiLink Ion_channel.
- Syntrophin wikiPageWikiLink Isoform.
- Syntrophin wikiPageWikiLink Kinase.
- Syntrophin wikiPageWikiLink Neuromuscular_junction.
- Syntrophin wikiPageWikiLink Nitric_oxide_synthase.
- Syntrophin wikiPageWikiLink PDZ_domain.
- Syntrophin wikiPageWikiLink Pleckstrin_homology_domain.
- Syntrophin wikiPageWikiLink Protein.
- Syntrophin wikiPageWikiLink Protein_domain.
- Syntrophin wikiPageWikiLink Protein_isoform.
- Syntrophin wikiPageWikiLink Sarcolemma.
- Syntrophin wikiPageWikiLink Signal_transducing_adaptor_protein.
- Syntrophin wikiPageWikiLink Signaling_protein.
- Syntrophin wikiPageWikiLink Skeletal_muscle.
- Syntrophin wikiPageWikiLink Torpedo_electric_organ.
- Syntrophin wikiPageWikiLink Water_channel.
- Syntrophin wikiPageWikiLinkText "Syntrophin".
- Syntrophin wikiPageWikiLinkText "syntrophin".
- Syntrophin hasPhotoCollection Syntrophin.
- Syntrophin wikiPageUsesTemplate Template:MeshName.
- Syntrophin wikiPageUsesTemplate Template:Muscle_tissue.
- Syntrophin wikiPageUsesTemplate Template:Protein-stub.
- Syntrophin wikiPageUsesTemplate Template:Reflist.
- Syntrophin subject Category:Proteins.
- Syntrophin hypernym Family.
- Syntrophin type Biomolecule.
- Syntrophin type Biomolecule.
- Syntrophin type Nutrient.
- Syntrophin comment "The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in torpedo electric organ (originally called "58K protein").".
- Syntrophin label "Syntrophin".
- Syntrophin sameAs m.02x4rn_.
- Syntrophin sameAs Q7662829.
- Syntrophin sameAs Q7662829.
- Syntrophin wasDerivedFrom Syntrophin?oldid=554768473.
- Syntrophin isPrimaryTopicOf Syntrophin.