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- Spindle_poison abstract "A spindle poison, also known as a spindle toxin, is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles. Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC). Unfortunately, spindle poisons, as numerous and varied as they are, still are yet to be 100% effective at ending the formation of tumors (neoplasms).Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments. The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins; each other in the activity of appropriately segregating replicated chromosomes. Certain compounds affecting the mitotic spindle have proven highly effective against solid tumors and hematological malignancies. Two specific families of antimitotic agents, vinca alkaloids and taxanes, interrupt the cell’s division by the agitation of microtubule dynamics. The vinca alkaloids work by causing the inhibition of the polymerization of tubulin into microtubules, resulting in the G2/M arrest within the cell cycle and eventually cell death. In contrast, the taxanes arrest the mitotic cell cycle by stabilizing microtubules against depolymerization. Even though numerous other spindle proteins exist that could be the target of novel chemotherapeutics, tubulin-binding agents are the only types in clinical use. Agents that affect the motor proteinkinesin are beginning to enter clinical trials. Another type, Paclitaxel, acts by attaching to tubulin within existing microtubules. Next, it stabilizes the polymer.".
- Spindle_poison wikiPageID "3027162".
- Spindle_poison wikiPageLength "5029".
- Spindle_poison wikiPageOutDegree "69".
- Spindle_poison wikiPageRevisionID "612557710".
- Spindle_poison wikiPageWikiLink Anaphase.
- Spindle_poison wikiPageWikiLink Anaphase-promoting_complex.
- Spindle_poison wikiPageWikiLink Anaphase_promoting_complex.
- Spindle_poison wikiPageWikiLink Aneuploidy.
- Spindle_poison wikiPageWikiLink Antimitotic_agents.
- Spindle_poison wikiPageWikiLink Apoptose.
- Spindle_poison wikiPageWikiLink Apoptosis.
- Spindle_poison wikiPageWikiLink Category:Mitotic_inhibitors.
- Spindle_poison wikiPageWikiLink Category:Poisons.
- Spindle_poison wikiPageWikiLink Cell_cycle.
- Spindle_poison wikiPageWikiLink Cell_division.
- Spindle_poison wikiPageWikiLink Centromere.
- Spindle_poison wikiPageWikiLink Chemotherapeutics.
- Spindle_poison wikiPageWikiLink Chemotherapy.
- Spindle_poison wikiPageWikiLink Chromatid.
- Spindle_poison wikiPageWikiLink Chromatids.
- Spindle_poison wikiPageWikiLink Chromosome.
- Spindle_poison wikiPageWikiLink Chromosomes.
- Spindle_poison wikiPageWikiLink Colchicine.
- Spindle_poison wikiPageWikiLink Cyclin-dependent_kinase.
- Spindle_poison wikiPageWikiLink Cyclin_B.
- Spindle_poison wikiPageWikiLink Cyclosome.
- Spindle_poison wikiPageWikiLink DNA.
- Spindle_poison wikiPageWikiLink Depolymerization.
- Spindle_poison wikiPageWikiLink Griseofulvin.
- Spindle_poison wikiPageWikiLink Kinesin.
- Spindle_poison wikiPageWikiLink Kinetochore.
- Spindle_poison wikiPageWikiLink Kinetochores.
- Spindle_poison wikiPageWikiLink Ligase.
- Spindle_poison wikiPageWikiLink Mebendazole.
- Spindle_poison wikiPageWikiLink Microtubule.
- Spindle_poison wikiPageWikiLink Microtubules.
- Spindle_poison wikiPageWikiLink Mitosis.
- Spindle_poison wikiPageWikiLink Mitotic_inhibitor.
- Spindle_poison wikiPageWikiLink Mitotic_spindle.
- Spindle_poison wikiPageWikiLink Neoplasm.
- Spindle_poison wikiPageWikiLink Neoplasms.
- Spindle_poison wikiPageWikiLink Paclitaxel.
- Spindle_poison wikiPageWikiLink Poison.
- Spindle_poison wikiPageWikiLink Polymer.
- Spindle_poison wikiPageWikiLink Protein.
- Spindle_poison wikiPageWikiLink Proteins.
- Spindle_poison wikiPageWikiLink Spindle_apparatus.
- Spindle_poison wikiPageWikiLink Taxane.
- Spindle_poison wikiPageWikiLink Taxanes.
- Spindle_poison wikiPageWikiLink Tubulin.
- Spindle_poison wikiPageWikiLink Tumors.
- Spindle_poison wikiPageWikiLink Ubiquitin_ligase.
- Spindle_poison wikiPageWikiLink Vinca_alkaloid.
- Spindle_poison wikiPageWikiLink Vinca_alkaloids.
- Spindle_poison wikiPageWikiLinkText "spindle poison".
- Spindle_poison hasPhotoCollection Spindle_poison.
- Spindle_poison wikiPageUsesTemplate Template:Chemotherapeutic_agents.
- Spindle_poison wikiPageUsesTemplate Template:Reflist.
- Spindle_poison subject Category:Mitotic_inhibitors.
- Spindle_poison subject Category:Poisons.
- Spindle_poison hypernym Poison.
- Spindle_poison type ChemicalCompound.
- Spindle_poison type Drug.
- Spindle_poison type Drug.
- Spindle_poison type Inhibitor.
- Spindle_poison comment "A spindle poison, also known as a spindle toxin, is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles. Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC).".
- Spindle_poison label "Spindle poison".
- Spindle_poison sameAs m.08lj6t.
- Spindle_poison sameAs Otrov_deobenog_vretena.
- Spindle_poison sameAs Otrov_deobenog_vretena.
- Spindle_poison sameAs Q7577503.
- Spindle_poison sameAs Q7577503.
- Spindle_poison wasDerivedFrom Spindle_poison?oldid=612557710.
- Spindle_poison isPrimaryTopicOf Spindle_poison.