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- Spider_toxin abstract "Spider toxins are a family of proteins produced by spiders which function as neurotoxins. The mechanism of many spider toxins is through blockage of calcium channels.A remotely related group of atracotoxins operate by opening sodium channels. Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels. The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix. The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides and other spider toxins, of the CSTX family.Spider potassium channel inhibitory toxins is another group of spider toxins. A representative of this group is hanatoxin, a 35 amino acid peptide toxin which was isolated from Chilean rose tarantula (Grammostola rosea, syn. G. spatulata) venom. It inhibits the drk1 voltage-gated potassium channel by altering the energetics of gating. See also Huwentoxin-1 IPR013140.".
- Spider_toxin symbol "Atracotoxin".
- Spider_toxin symbol "Toxin_12".
- Spider_toxin symbol "Toxin_35".
- Spider_toxin symbol "Toxin_9".
- Spider_toxin thumbnail 1IVA.pdb.png?width=300.
- Spider_toxin wikiPageID "14853309".
- Spider_toxin wikiPageLength "4496".
- Spider_toxin wikiPageOutDegree "16".
- Spider_toxin wikiPageRevisionID "593082598".
- Spider_toxin wikiPageWikiLink Agelenopsis_aperta.
- Spider_toxin wikiPageWikiLink Atracotoxin.
- Spider_toxin wikiPageWikiLink Calcium_channel.
- Spider_toxin wikiPageWikiLink Category:Invertebrate_toxins.
- Spider_toxin wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Spider_toxin wikiPageWikiLink Category:Protein_domains.
- Spider_toxin wikiPageWikiLink Chilean_rose_tarantula.
- Spider_toxin wikiPageWikiLink Delta_atracotoxin.
- Spider_toxin wikiPageWikiLink Hanatoxin.
- Spider_toxin wikiPageWikiLink Inhibitor_cystine_knot.
- Spider_toxin wikiPageWikiLink Neurotoxin.
- Spider_toxin wikiPageWikiLink Protein_family.
- Spider_toxin wikiPageWikiLink Raventoxin.
- Spider_toxin wikiPageWikiLink Sodium_channel.
- Spider_toxin wikiPageWikiLink Spider.
- Spider_toxin wikiPageWikiLink Synonym_(taxonomy).
- Spider_toxin wikiPageWikiLink Voltage-gated_potassium_channel.
- Spider_toxin wikiPageWikiLinkText "Spider toxin".
- Spider_toxin wikiPageWikiLinkText "spider toxin".
- Spider_toxin caption "Solution structure of omega-agatoxin-Aa4a from Agelenopsis aperta.".
- Spider_toxin hasPhotoCollection Spider_toxin.
- Spider_toxin interpro "IPR004169".
- Spider_toxin interpro "IPR008017".
- Spider_toxin interpro "IPR011142".
- Spider_toxin interpro "IPR011696".
- Spider_toxin name "Delta Atracotoxin".
- Spider_toxin name "Spider potassium channel inhibitory toxin".
- Spider_toxin name "Spider toxin CSTX family".
- Spider_toxin name "Spider toxin".
- Spider_toxin opmFamily "120".
- Spider_toxin opmProtein "1".
- Spider_toxin pdb ":1-42 :1-42".
- Spider_toxin pdb ":4-48 :4-48 :4-48 :39-83 :39-73 :39-83".
- Spider_toxin pdb "A:49-79 A:1-31 A:53-85 A:1-33 A:1-33 A:1-33 A:2-28 A:50-77 A:47-78 A:1-30 A:1-30 A:1-32".
- Spider_toxin pfam "PF02819".
- Spider_toxin pfam "PF05353".
- Spider_toxin pfam "PF07740".
- Spider_toxin pfam "PF10530".
- Spider_toxin pfamClan "CL0083".
- Spider_toxin prosite "PDOC60029".
- Spider_toxin scop "1".
- Spider_toxin scop "3600.0".
- Spider_toxin symbol "Atracotoxin".
- Spider_toxin symbol "Toxin_12".
- Spider_toxin symbol "Toxin_35".
- Spider_toxin symbol "Toxin_9".
- Spider_toxin wikiPageUsesTemplate Template:Cite_journal.
- Spider_toxin wikiPageUsesTemplate Template:InterPro.
- Spider_toxin wikiPageUsesTemplate Template:InterPro_content.
- Spider_toxin wikiPageUsesTemplate Template:Membrane-protein-stub.
- Spider_toxin wikiPageUsesTemplate Template:Pfam_box.
- Spider_toxin wikiPageUsesTemplate Template:Refbegin.
- Spider_toxin wikiPageUsesTemplate Template:Refend.
- Spider_toxin wikiPageUsesTemplate Template:Reflist.
- Spider_toxin subject Category:Invertebrate_toxins.
- Spider_toxin subject Category:Peripheral_membrane_proteins.
- Spider_toxin subject Category:Protein_domains.
- Spider_toxin hypernym Family.
- Spider_toxin type Biomolecule.
- Spider_toxin type Protein.
- Spider_toxin type Chemical.
- Spider_toxin type Domain.
- Spider_toxin type Toxin.
- Spider_toxin type Thing.
- Spider_toxin type Q206229.
- Spider_toxin type Q8054.
- Spider_toxin comment "Spider toxins are a family of proteins produced by spiders which function as neurotoxins. The mechanism of many spider toxins is through blockage of calcium channels.A remotely related group of atracotoxins operate by opening sodium channels. Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels.".
- Spider_toxin label "Spider toxin".
- Spider_toxin sameAs m.03g_68t.
- Spider_toxin sameAs Q7577067.
- Spider_toxin sameAs Q7577067.
- Spider_toxin wasDerivedFrom Spider_toxin?oldid=593082598.
- Spider_toxin depiction 1IVA.pdb.png.
- Spider_toxin isPrimaryTopicOf Spider_toxin.