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Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Sofosbuvir> ?p ?o }

• Sofosbuvir abstract "Sofosbuvir (brand names Sovaldi, Hepcinat, Resof, Hepcvir, SoviHep) is a nucleotide analog used in combination with other drugs for the treatment of hepatitis C virus (HCV) infection. It has been marketed since 2013. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon, an injectable drug with severe side effects that is a key component of older drug combinations for the treatment of HCV.Sofosbuvir inhibits the RNA polymerase that the hepatitis C virus uses to replicate its RNA. It was discovered at Pharmasset and developed by Gilead Sciences.In 2013, the FDA approved sofosbuvir in combination with ribavirin (RBV) for oral dual therapy of HCV genotypes 2 and 3, and for triple therapy with injected pegylated interferon (pegIFN) and RBV for treatment-naive patients with HCV genotypes 1 and 4. In 2014 a combination of sofosbuvir with the viral NS5A inhibitor ledipasvir was approved. This latter combination provides high cure rates in people infected with genotype 1 (the most common subtype in the U.S., Japan, and much of Europe) without the use of interferon, irrespective of prior treatment failure or the presence of cirrhosis.The price of sofosbuvir, quoted in various media sources as $84,000 to $168,000 for a course of treatment in the U.S., £35,000 in the UK for 12 weeks has engendered considerable controversy. In September 2014, Gilead announced that it would permit generic manufacturers to sell sofosbuvir in 91 developing countries and that it would sell a name brand version of the product in India for approximately $300 per course of treatment.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.".
• Sofosbuvir atcPrefix "J05".
• Sofosbuvir atcSuffix "AX15".
• Sofosbuvir bioavailability "92.0".
• Sofosbuvir casNumber "1190307-88-0".
• Sofosbuvir chEBI "85083".
• Sofosbuvir drugbank "DB08934".
• Sofosbuvir fdaUniiCode "WJ6CA3ZU8B".
• Sofosbuvir iupacName "Isopropyl (2S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate".
• Sofosbuvir pubchem "45375808".
• Sofosbuvir thumbnail Sofosbuvir.svg?width=300.
• Sofosbuvir wikiPageExternalLink www.ribavirinpregnancyregistry.com.
• Sofosbuvir wikiPageID "33832492".
• Sofosbuvir wikiPageLength "32307".
• Sofosbuvir wikiPageOutDegree "72".
• Sofosbuvir wikiPageRevisionID "679283061".
• Sofosbuvir wikiPageWikiLink Active_metabolite.
• Sofosbuvir wikiPageWikiLink American_Association_for_the_Study_of_Liver_Diseases.
• Sofosbuvir wikiPageWikiLink Amiodarone.
• Sofosbuvir wikiPageWikiLink Artificial_cardiac_pacemaker.
• Sofosbuvir wikiPageWikiLink Breakthrough_therapy.
• Sofosbuvir wikiPageWikiLink Bristol-Myers_Squibb.
• Sofosbuvir wikiPageWikiLink Cardiac_arrest.
• Sofosbuvir wikiPageWikiLink Cardiff_University.
• Sofosbuvir wikiPageWikiLink Category:Anti-hepatitis_C_agents.
• Sofosbuvir wikiPageWikiLink Category:Breakthrough_therapy.
• Sofosbuvir wikiPageWikiLink Category:Organofluorides.
• Sofosbuvir wikiPageWikiLink Category:Prodrugs.
• Sofosbuvir wikiPageWikiLink Category:Propionates.
• Sofosbuvir wikiPageWikiLink Category:Pyrimidinediones.
• Sofosbuvir wikiPageWikiLink Ciclosporin.
• Sofosbuvir wikiPageWikiLink Coinfection.
• Sofosbuvir wikiPageWikiLink Daclatasvir.
• Sofosbuvir wikiPageWikiLink Darunavir.
• Sofosbuvir wikiPageWikiLink Doctors_of_the_World.
• Sofosbuvir wikiPageWikiLink Doctors_without_Borders.
• Sofosbuvir wikiPageWikiLink Drug_development.
• Sofosbuvir wikiPageWikiLink Efavirenz.
• Sofosbuvir wikiPageWikiLink Emtricitabine.
• Sofosbuvir wikiPageWikiLink European_Patent_Office.
• Sofosbuvir wikiPageWikiLink FDA.
• Sofosbuvir wikiPageWikiLink Food_and_Drug_Administration.
• Sofosbuvir wikiPageWikiLink Gilead_Sciences.
• Sofosbuvir wikiPageWikiLink HIV.
• Sofosbuvir wikiPageWikiLink Harvoni.
• Sofosbuvir wikiPageWikiLink Health_system.
• Sofosbuvir wikiPageWikiLink Hepatitis_C.
• Sofosbuvir wikiPageWikiLink Hepatitis_C_virus.
• Sofosbuvir wikiPageWikiLink Hypericum_perforatum.
• Sofosbuvir wikiPageWikiLink India.
• Sofosbuvir wikiPageWikiLink Indian_Patent_Office.
• Sofosbuvir wikiPageWikiLink Infectious_Diseases_Society_of_America.
• Sofosbuvir wikiPageWikiLink Intestinal_epithelium.
• Sofosbuvir wikiPageWikiLink Johnson_&_Johnson.
• Sofosbuvir wikiPageWikiLink Ledipasvir.
• Sofosbuvir wikiPageWikiLink sofosbuvir.
• Sofosbuvir wikiPageWikiLink Methadone.
• Sofosbuvir wikiPageWikiLink Médecins_Sans_Frontières.
• Sofosbuvir wikiPageWikiLink Médecins_du_Monde.
• Sofosbuvir wikiPageWikiLink NS5A.
• Sofosbuvir wikiPageWikiLink NS5B.
• Sofosbuvir wikiPageWikiLink Neutropenia.
• Sofosbuvir wikiPageWikiLink New_Drug_Application.
• Sofosbuvir wikiPageWikiLink New_drug_application_(FDA).
• Sofosbuvir wikiPageWikiLink P-glycoprotein.
• Sofosbuvir wikiPageWikiLink Pacemaker.
• Sofosbuvir wikiPageWikiLink Pegylated_interferon.
• Sofosbuvir wikiPageWikiLink Pharmasset.
• Sofosbuvir wikiPageWikiLink Philadelphia.
• Sofosbuvir wikiPageWikiLink Prodrug.
• Sofosbuvir wikiPageWikiLink Protide.
• Sofosbuvir wikiPageWikiLink RNA-dependent_RNA_polymerase.
• Sofosbuvir wikiPageWikiLink RNA_polymerase.
• Sofosbuvir wikiPageWikiLink Raltegravir.
• Sofosbuvir wikiPageWikiLink Ribavirin.
• Sofosbuvir wikiPageWikiLink Rilpivirine.
• Sofosbuvir wikiPageWikiLink Ritonavir.
• Sofosbuvir wikiPageWikiLink SEPTA.
• Sofosbuvir wikiPageWikiLink Simeprevir.
• Sofosbuvir wikiPageWikiLink Sofosbuvir.
• Sofosbuvir wikiPageWikiLink Sovaldi.
• Sofosbuvir wikiPageWikiLink St._Johns_wort.
• Sofosbuvir wikiPageWikiLink Tacrolimus.
• Sofosbuvir wikiPageWikiLink Tenofovir.
• Sofosbuvir wikiPageWikiLink Tenofovir_disoproxil.
• Sofosbuvir wikiPageWikiLink Tipranavir.
• Sofosbuvir wikiPageWikiLink WHO_Model_List_of_Essential_Medicines.
• Sofosbuvir wikiPageWikiLink World_Health_Organizations_List_of_Essential_Medicines.
• Sofosbuvir wikiPageWikiLink nowiki%3E(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl%5Dmethoxy-phenoxy-phosphoryl%5Damino%5Dpropanoate.
• Sofosbuvir wikiPageWikiLink File:Sofosbuvir_prodrug_chemistry.svg.
• Sofosbuvir wikiPageWikiLinkText "Sofosbuvir".
• Sofosbuvir wikiPageWikiLinkText "Sovaldi".
• Sofosbuvir wikiPageWikiLinkText "sofosbuvir".
• Sofosbuvir atcPrefix "J05".
• Sofosbuvir atcSuffix "AX15".
• Sofosbuvir bioavailability "92.0".
• Sofosbuvir c "22".
• Sofosbuvir casNumber "1190307".
• Sofosbuvir chebi "85083".
• Sofosbuvir chembl "1259059".

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