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- Skewed_X-inactivation abstract "Skewed X chromosome inactivation occurs when the inactivation of one X chromosome is favored over the other, leading to an uneven number of cells with each chromosome inactivated. It is usually defined as one allele being found on the active X chromosome in over 75% of cells, and extreme skewing is when over 90% of cells have inactivated the same X chromosome. It can be caused by primary nonrandom inactivation, either by chance due to a small cell pool or directed by genes, or caused by secondary nonrandom inactivation, which occurs by selection. Most females will have some levels of skewing. It is relatively common in adult females; around 35% of women have skewed ratio over 70:30, and 7% of women have an extreme skewed ratio of over 90:10. This is of medical significance due to the potential for the expression of disease genes present on the X chromosome that are normally not expressed due to random X inactivation. X chromosome inactivation occurs in females to provide dosage compensation between the sexes. If females kept both X chromosomes active they would have twice the number of active X genes than males, who only have one copy of the X chromosome. At approximately the time of implantation (see Implantation (human embryo), one of the two X chromosomes is randomly selected for inactivation. The cell undergoes transcriptional and epigenetic changes to ensure this inactivation is permanent. All progeny from these initial cells will maintain the inactivation of the same chromosome, resulting in a mosaic pattern of cells in females.".
- Skewed_X-inactivation wikiPageID "22689624".
- Skewed_X-inactivation wikiPageLength "22889".
- Skewed_X-inactivation wikiPageOutDegree "36".
- Skewed_X-inactivation wikiPageRevisionID "683672542".
- Skewed_X-inactivation wikiPageWikiLink Atrophy.
- Skewed_X-inactivation wikiPageWikiLink Autism.
- Skewed_X-inactivation wikiPageWikiLink Autoimmune_disease.
- Skewed_X-inactivation wikiPageWikiLink Autoimmune_thyroiditis.
- Skewed_X-inactivation wikiPageWikiLink Blood_cell.
- Skewed_X-inactivation wikiPageWikiLink Category:Epigenetics.
- Skewed_X-inactivation wikiPageWikiLink Cis-Regulatory_element.
- Skewed_X-inactivation wikiPageWikiLink DNA_methylation.
- Skewed_X-inactivation wikiPageWikiLink Dosage_compensation.
- Skewed_X-inactivation wikiPageWikiLink Esophageal_cancer.
- Skewed_X-inactivation wikiPageWikiLink Exome_sequencing.
- Skewed_X-inactivation wikiPageWikiLink Genomic_imprinting.
- Skewed_X-inactivation wikiPageWikiLink Glycogen.
- Skewed_X-inactivation wikiPageWikiLink Glycogen_phosphorylase.
- Skewed_X-inactivation wikiPageWikiLink Glycogen_storage_disease.
- Skewed_X-inactivation wikiPageWikiLink Implantation_(human_embryo).
- Skewed_X-inactivation wikiPageWikiLink Ketoacidosis.
- Skewed_X-inactivation wikiPageWikiLink Klinefelter_syndrome.
- Skewed_X-inactivation wikiPageWikiLink MECP2.
- Skewed_X-inactivation wikiPageWikiLink Marsupial.
- Skewed_X-inactivation wikiPageWikiLink Messenger_RNA.
- Skewed_X-inactivation wikiPageWikiLink Miscarriage.
- Skewed_X-inactivation wikiPageWikiLink Ovarian_cancer.
- Skewed_X-inactivation wikiPageWikiLink Phosphorylase_kinase.
- Skewed_X-inactivation wikiPageWikiLink Phosphorylation.
- Skewed_X-inactivation wikiPageWikiLink Polymorphism_(biology).
- Skewed_X-inactivation wikiPageWikiLink Rett_Syndrome.
- Skewed_X-inactivation wikiPageWikiLink Rett_syndrome.
- Skewed_X-inactivation wikiPageWikiLink Scleroderma.
- Skewed_X-inactivation wikiPageWikiLink Sex_linkage.
- Skewed_X-inactivation wikiPageWikiLink Single-nucleotide_polymorphism.
- Skewed_X-inactivation wikiPageWikiLink Tsix.
- Skewed_X-inactivation wikiPageWikiLink Tumor_suppressor_gene.
- Skewed_X-inactivation wikiPageWikiLink X-inactivation.
- Skewed_X-inactivation wikiPageWikiLink XIST_(gene).
- Skewed_X-inactivation wikiPageWikiLinkText "Skewed X-inactivation".
- Skewed_X-inactivation wikiPageWikiLinkText "non-random".
- Skewed_X-inactivation wikiPageWikiLinkText "skewed X inactivation".
- Skewed_X-inactivation wikiPageWikiLinkText "skewed X-inactivation".
- Skewed_X-inactivation wikiPageWikiLinkText "skewed".
- Skewed_X-inactivation hasPhotoCollection Skewed_X-inactivation.
- Skewed_X-inactivation wikiPageUsesTemplate Template:Reflist.
- Skewed_X-inactivation subject Category:Epigenetics.
- Skewed_X-inactivation type Epigenetic.
- Skewed_X-inactivation comment "Skewed X chromosome inactivation occurs when the inactivation of one X chromosome is favored over the other, leading to an uneven number of cells with each chromosome inactivated. It is usually defined as one allele being found on the active X chromosome in over 75% of cells, and extreme skewing is when over 90% of cells have inactivated the same X chromosome.".
- Skewed_X-inactivation label "Skewed X-inactivation".
- Skewed_X-inactivation sameAs Inattivazione_non_casuale_del_cromosoma_X.
- Skewed_X-inactivation sameAs m.05zmj6r.
- Skewed_X-inactivation sameAs Q7534814.
- Skewed_X-inactivation sameAs Q7534814.
- Skewed_X-inactivation wasDerivedFrom Skewed_X-inactivation?oldid=683672542.
- Skewed_X-inactivation isPrimaryTopicOf Skewed_X-inactivation.