Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Single-domain_antibody> ?p ?o }
- Single-domain_antibody abstract "A single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, single-domain antibodies are much smaller than common antibodies (150–160 kDa) which are composed of two heavy protein chains and two light chains, and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 kDa, two variable domains, one from a light and one from a heavy chain).The first single-domain antibodies were engineered from heavy-chain antibodies found in camelids; these are called VHH fragments. Cartilaginous fishes also have heavy-chain antibodies (IgNAR, 'immunoglobulin new antigen receptor'), from which single-domain antibodies called VNAR fragments can be obtained. An alternative approach is to split the dimeric variable domains from common immunoglobulin G (IgG) from humans or mice into monomers. Although most research into single-domain antibodies is currently based on heavy chain variable domains, nanobodies derived from light chains have also been shown to bind specifically to target epitopes.Single-domain camelids antibodies have been shown to be just as specific as a regular antibody and in some cases they are more robust. As well, they are easily isolated using the same phage panning procedure used for traditional antibodies, allowing them to cultured in vitro in large concentrations. The smaller size and single domain make these antibodies easier to transform into bacterial cells for bulk production, making them ideal for research purposes. Single-domain antibodies are being researched for multiple pharmaceutical applications and have potential for use in the treatment of acute coronary syndrome, cancer and Alzheimer's disease.".
- Single-domain_antibody thumbnail 1I3V_(Lama_VHH_domain_unligated).png?width=300.
- Single-domain_antibody wikiPageID "2468191".
- Single-domain_antibody wikiPageLength "23068".
- Single-domain_antibody wikiPageOutDegree "87".
- Single-domain_antibody wikiPageRevisionID "678367968".
- Single-domain_antibody wikiPageWikiLink Ablynx.
- Single-domain_antibody wikiPageWikiLink Absorption_(pharmacokinetics).
- Single-domain_antibody wikiPageWikiLink Acute_coronary_syndrome.
- Single-domain_antibody wikiPageWikiLink Affinity_maturation.
- Single-domain_antibody wikiPageWikiLink Alpaca.
- Single-domain_antibody wikiPageWikiLink Alzheimers_disease.
- Single-domain_antibody wikiPageWikiLink Amino_acid.
- Single-domain_antibody wikiPageWikiLink Antibody.
- Single-domain_antibody wikiPageWikiLink Antigen.
- Single-domain_antibody wikiPageWikiLink Atomic_mass_unit.
- Single-domain_antibody wikiPageWikiLink Biological_half-life.
- Single-domain_antibody wikiPageWikiLink Biosensor.
- Single-domain_antibody wikiPageWikiLink Blood–brain_barrier.
- Single-domain_antibody wikiPageWikiLink Brain_tumor.
- Single-domain_antibody wikiPageWikiLink CDR3.
- Single-domain_antibody wikiPageWikiLink Camel.
- Single-domain_antibody wikiPageWikiLink Camelid.
- Single-domain_antibody wikiPageWikiLink Cancer.
- Single-domain_antibody wikiPageWikiLink Cancer_of_the_brain.
- Single-domain_antibody wikiPageWikiLink Cartilaginous_fishes.
- Single-domain_antibody wikiPageWikiLink Category:Monoclonal_antibodies.
- Single-domain_antibody wikiPageWikiLink Chaperone_(protein).
- Single-domain_antibody wikiPageWikiLink Chondrichthyes.
- Single-domain_antibody wikiPageWikiLink Chromobody.
- Single-domain_antibody wikiPageWikiLink Clinical_trial.
- Single-domain_antibody wikiPageWikiLink Clinical_trials.
- Single-domain_antibody wikiPageWikiLink Clone_(genetics).
- Single-domain_antibody wikiPageWikiLink Colon_cancer.
- Single-domain_antibody wikiPageWikiLink Colorectal_cancer.
- Single-domain_antibody wikiPageWikiLink Complement_system.
- Single-domain_antibody wikiPageWikiLink Complementarity_determining_region.
- Single-domain_antibody wikiPageWikiLink Crystallization.
- Single-domain_antibody wikiPageWikiLink Cytotoxicity.
- Single-domain_antibody wikiPageWikiLink DNA_sequence.
- Single-domain_antibody wikiPageWikiLink Dandruff.
- Single-domain_antibody wikiPageWikiLink Detergent.
- Single-domain_antibody wikiPageWikiLink Digestion.
- Single-domain_antibody wikiPageWikiLink Dromedaries.
- Single-domain_antibody wikiPageWikiLink Dromedary.
- Single-domain_antibody wikiPageWikiLink E._coli.
- Single-domain_antibody wikiPageWikiLink Enzyme.
- Single-domain_antibody wikiPageWikiLink Epitope.
- Single-domain_antibody wikiPageWikiLink Epitopes.
- Single-domain_antibody wikiPageWikiLink Escherichia_coli.
- Single-domain_antibody wikiPageWikiLink Fab_fragment.
- Single-domain_antibody wikiPageWikiLink Fc_region.
- Single-domain_antibody wikiPageWikiLink Fibroblast.
- Single-domain_antibody wikiPageWikiLink Fibroblasts.
- Single-domain_antibody wikiPageWikiLink Fluorophore.
- Single-domain_antibody wikiPageWikiLink Fragment_antigen-binding.
- Single-domain_antibody wikiPageWikiLink Fragment_crystallizable_region.
- Single-domain_antibody wikiPageWikiLink Gastric_acid.
- Single-domain_antibody wikiPageWikiLink Gastrointestinal_tract.
- Single-domain_antibody wikiPageWikiLink Green_fluorescent_protein.
- Single-domain_antibody wikiPageWikiLink HER2.
- Single-domain_antibody wikiPageWikiLink neu.
- Single-domain_antibody wikiPageWikiLink Heavy-chain_antibodies.
- Single-domain_antibody wikiPageWikiLink Heavy-chain_antibody.
- Single-domain_antibody wikiPageWikiLink Hemagglutinin.
- Single-domain_antibody wikiPageWikiLink Hemaglutinin.
- Single-domain_antibody wikiPageWikiLink Homology_(biology).
- Single-domain_antibody wikiPageWikiLink Human_gastrointestinal_tract.
- Single-domain_antibody wikiPageWikiLink Humanized_antibody.
- Single-domain_antibody wikiPageWikiLink Immunoglobulin_G.
- Single-domain_antibody wikiPageWikiLink Immunoglobulin_heavy_chain.
- Single-domain_antibody wikiPageWikiLink Immunoglobulin_light_chain.
- Single-domain_antibody wikiPageWikiLink Inflammatory_bowel_disease.
- Single-domain_antibody wikiPageWikiLink Influenza_A_virus_subtype_H5N1.
- Single-domain_antibody wikiPageWikiLink Intestine.
- Single-domain_antibody wikiPageWikiLink KDa.
- Single-domain_antibody wikiPageWikiLink Kidney.
- Single-domain_antibody wikiPageWikiLink Lipophilic.
- Single-domain_antibody wikiPageWikiLink Lipophilicity.
- Single-domain_antibody wikiPageWikiLink Llama.
- Single-domain_antibody wikiPageWikiLink MRNA.
- Single-domain_antibody wikiPageWikiLink Malassezia.
- Single-domain_antibody wikiPageWikiLink Malassezia_furfur.
- Single-domain_antibody wikiPageWikiLink Messenger_RNA.
- Single-domain_antibody wikiPageWikiLink Molecular_cloning.
- Single-domain_antibody wikiPageWikiLink Molecular_mass.
- Single-domain_antibody wikiPageWikiLink Monomer.
- Single-domain_antibody wikiPageWikiLink Murinae.
- Single-domain_antibody wikiPageWikiLink Murine.
- Single-domain_antibody wikiPageWikiLink Mutagenesis.
- Single-domain_antibody wikiPageWikiLink Nucleic_acid_sequence.
- Single-domain_antibody wikiPageWikiLink Peptide.
- Single-domain_antibody wikiPageWikiLink Percutaneous_coronary_intervention.
- Single-domain_antibody wikiPageWikiLink Phage_display.
- Single-domain_antibody wikiPageWikiLink Photothermal_therapy.
- Single-domain_antibody wikiPageWikiLink Polymerase_chain_reaction.
- Single-domain_antibody wikiPageWikiLink Prostate-specific_antigen.
- Single-domain_antibody wikiPageWikiLink Protease.
- Single-domain_antibody wikiPageWikiLink Proteases.
- Single-domain_antibody wikiPageWikiLink Protein_dimer.