Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Signal_peptidase> ?p ?o }
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- Signal_peptidase abstract "Signal peptidases are enzymes that convert secretory and some membrane proteins to their mature forms by cleaving their signal peptides from their N-terminals.Signal peptidases were initially observed in endoplasmic reticulum (ER)-derived membrane fractions isolated from mouse myeloma cells. The key observation by César Milstein and colleagues was that immunoglobulin light chains were produced in a higher molecular weight form, which became processed by the ER membrane fraction. This finding was directly followed by the discovery of the translocation machinery. Signal peptidases are also found in prokaryotes as well as the protein import machinery of mitochondria and chloroplasts.All signal peptidases described so far are serine proteases. The active site that endoproteolytically cleaves signal peptides from translocated precursor proteins is located at the extracytoplasmic site of the membrane. The eukaryotic signal peptidase is an integral membrane protein complex. The first subunit, which was identified by yeast genetics is Sec11, a 17 kDa membrane protein that is associated with three subunits termed Spc3p (21 kDa), Spc2p (18 kDa) and Spc1p (11 kDa). Sec11 is the only essential factor for signal peptide processing as can be deduced from a growth defect upon its deletion. The functional signal peptidase complex was first purified from a canine ER membrane fraction. The five mammalian subunits are named SPC12, SPC18, SPC21, SPC22/23 and SPC25 according to their molecular weight.".
- Signal_peptidase symbol "Peptidase_S26".
- Signal_peptidase wikiPageID "32181058".
- Signal_peptidase wikiPageLength "4077".
- Signal_peptidase wikiPageOutDegree "21".
- Signal_peptidase wikiPageRevisionID "607874133".
- Signal_peptidase wikiPageWikiLink Category:EC_3.4.21.
- Signal_peptidase wikiPageWikiLink Category:EC_3.4.23.
- Signal_peptidase wikiPageWikiLink Chloroplast.
- Signal_peptidase wikiPageWikiLink Chloroplasts.
- Signal_peptidase wikiPageWikiLink César_Milstein.
- Signal_peptidase wikiPageWikiLink Endoplasmic_reticulum.
- Signal_peptidase wikiPageWikiLink Enzyme.
- Signal_peptidase wikiPageWikiLink Membrane_protein.
- Signal_peptidase wikiPageWikiLink Mitochondria.
- Signal_peptidase wikiPageWikiLink Mitochondrion.
- Signal_peptidase wikiPageWikiLink Multiple_myeloma.
- Signal_peptidase wikiPageWikiLink Myeloma.
- Signal_peptidase wikiPageWikiLink N-terminus.
- Signal_peptidase wikiPageWikiLink Prokaryote.
- Signal_peptidase wikiPageWikiLink Prokaryotes.
- Signal_peptidase wikiPageWikiLink SEC11A.
- Signal_peptidase wikiPageWikiLink SPC18.
- Signal_peptidase wikiPageWikiLink SPC25.
- Signal_peptidase wikiPageWikiLink SPCS1.
- Signal_peptidase wikiPageWikiLink SPCS3.
- Signal_peptidase wikiPageWikiLink Serine_protease.
- Signal_peptidase wikiPageWikiLink Serine_proteases.
- Signal_peptidase wikiPageWikiLink Signal_peptide.
- Signal_peptidase wikiPageWikiLink Signal_peptide_peptidase.
- Signal_peptidase wikiPageWikiLink Signal_peptides.
- Signal_peptidase wikiPageWikiLink Translocon.
- Signal_peptidase wikiPageWikiLinkText "Signal peptidase".
- Signal_peptidase wikiPageWikiLinkText "signal peptidase".
- Signal_peptidase casNumber "171715".
- Signal_peptidase casNumber "65979".
- Signal_peptidase ecNumber "3.4".
- Signal_peptidase goCode "9004".
- Signal_peptidase goCode "9005".
- Signal_peptidase hasPhotoCollection Signal_peptidase.
- Signal_peptidase interpro "IPR019533".
- Signal_peptidase iubmbEcNumber "3".
- Signal_peptidase merops "S26".
- Signal_peptidase name "Peptidase_S26".
- Signal_peptidase name "Signal peptidase I".
- Signal_peptidase name "Signal peptidase II".
- Signal_peptidase opmFamily "178".
- Signal_peptidase opmProtein "604800.0".
- Signal_peptidase pfam "PF10502".
- Signal_peptidase pfamClan "CL0299".
- Signal_peptidase symbol "Peptidase_S26".
- Signal_peptidase wikiPageUsesTemplate Template:Enzyme.
- Signal_peptidase wikiPageUsesTemplate Template:Infobox_protein_family.
- Signal_peptidase wikiPageUsesTemplate Template:MeshName.
- Signal_peptidase wikiPageUsesTemplate Template:Reflist.
- Signal_peptidase subject Category:EC_3.4.21.
- Signal_peptidase subject Category:EC_3.4.23.
- Signal_peptidase hypernym Enzymes.
- Signal_peptidase type Biomolecule.
- Signal_peptidase type Protein.
- Signal_peptidase type Thing.
- Signal_peptidase type Q206229.
- Signal_peptidase type Q8054.
- Signal_peptidase comment "Signal peptidases are enzymes that convert secretory and some membrane proteins to their mature forms by cleaving their signal peptides from their N-terminals.Signal peptidases were initially observed in endoplasmic reticulum (ER)-derived membrane fractions isolated from mouse myeloma cells. The key observation by César Milstein and colleagues was that immunoglobulin light chains were produced in a higher molecular weight form, which became processed by the ER membrane fraction.".
- Signal_peptidase label "Signal peptidase".
- Signal_peptidase sameAs Peptidasi_del_segnale.
- Signal_peptidase sameAs m.0gy18zg.
- Signal_peptidase sameAs Q7512720.
- Signal_peptidase sameAs Q7512720.
- Signal_peptidase wasDerivedFrom Signal_peptidase?oldid=607874133.
- Signal_peptidase isPrimaryTopicOf Signal_peptidase.