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- Sickle_cell_nephropathy abstract "Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease, it causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors sickling of red blood cells, with resultant local infarction (papillary necrosis). Functional tubule defects in patients with sickle cell disease are likely the result of partial ischemic injury to the renal tubules.Also the sickle cell disease in young patients is characterized by renal hyperperfusion, glomerular hypertrophy, and glomerular hyperfiltration. Many of these individuals eventually develop a glomerulopathy leading to glomerular proteinuria (present in as many as 30%) and, in some, the nephrotic syndrome. Co-inheritance of microdeletions in the -globin gene (thalassemia) appear to protect against the development of nephropathy and are associated with lower mean arterial pressure and less protein in the urine.Mild increases in the blood levels of nitrogen and uric acid can also develop. Advanced kidney failure and high blood urea levels occur in 10% of cases. Pathologic examination reveals the typical lesion of "hyperfiltration nephropathy" namely, focal segmental glomerular sclerosis. This finding has led to the suggestion that anemia-induced hyperfiltration in childhood is the principal cause of the adult glomerulopathy. Nephron loss secondary to ischemic injury also contributes to the development of azotemia in these patients.In addition to the glomerulopathy described above, kidney complications of sickle cell disease include cortical infarcts leading to loss of function, persistent bloody urine, and perinephric hematomas. Papillary infarcts, demonstrable radiographically in 50% of patients with sickle trait, lead to an increased risk of bacterial infection in the scarred kidney tissues and functional tubule abnormalities. The presence of visible blood in the urine without pain occurs with a higher frequency in sickle trait than in sickle cell disease and likely results from infarctive episodes in the renal medulla. Functional tubule abnormalities such as nephrogenic diabetes insipidus result from marked reduction in vasa recta blood flow, combined with ischemic tubule injury. This concentrating defect places these patients at increased risk of dehydration and, hence, sickling crises. The concentrating defect also occurs in individuals with sickle trait. Other tubule defects involve potassium and hydrogen ion excretion, occasionally leading to high blood potassium, metabolic acidosis, and a defect in uric acid excretion which, combined with increased purine synthesis in the bone marrow, results in high blood uric acid levels.".
- Sickle_cell_nephropathy wikiPageID "21751036".
- Sickle_cell_nephropathy wikiPageLength "4090".
- Sickle_cell_nephropathy wikiPageOutDegree "68".
- Sickle_cell_nephropathy wikiPageRevisionID "656029491".
- Sickle_cell_nephropathy wikiPageWikiLink ACE_inhibitor.
- Sickle_cell_nephropathy wikiPageWikiLink ACE_inhibitors.
- Sickle_cell_nephropathy wikiPageWikiLink Adipose_capsule_of_kidney.
- Sickle_cell_nephropathy wikiPageWikiLink Adult.
- Sickle_cell_nephropathy wikiPageWikiLink Anemia.
- Sickle_cell_nephropathy wikiPageWikiLink Azotemia.
- Sickle_cell_nephropathy wikiPageWikiLink Bacteria.
- Sickle_cell_nephropathy wikiPageWikiLink Bacterial.
- Sickle_cell_nephropathy wikiPageWikiLink Blood.
- Sickle_cell_nephropathy wikiPageWikiLink Bone_marrow.
- Sickle_cell_nephropathy wikiPageWikiLink Category:Kidney_diseases.
- Sickle_cell_nephropathy wikiPageWikiLink Cerebral_cortex.
- Sickle_cell_nephropathy wikiPageWikiLink Childhood.
- Sickle_cell_nephropathy wikiPageWikiLink Chronic_kidney_disease.
- Sickle_cell_nephropathy wikiPageWikiLink Dehydration.
- Sickle_cell_nephropathy wikiPageWikiLink Deletion_(genetics).
- Sickle_cell_nephropathy wikiPageWikiLink End-stage_kidney_disease.
- Sickle_cell_nephropathy wikiPageWikiLink Excretion.
- Sickle_cell_nephropathy wikiPageWikiLink Focal_segmental_glomerular_sclerosis.
- Sickle_cell_nephropathy wikiPageWikiLink Focal_segmental_glomerulosclerosis.
- Sickle_cell_nephropathy wikiPageWikiLink Gene.
- Sickle_cell_nephropathy wikiPageWikiLink Globin.
- Sickle_cell_nephropathy wikiPageWikiLink Glomerular_hyperfiltration.
- Sickle_cell_nephropathy wikiPageWikiLink Glomerular_hypertrophy.
- Sickle_cell_nephropathy wikiPageWikiLink Glomerulopathy.
- Sickle_cell_nephropathy wikiPageWikiLink Graft_(surgery).
- Sickle_cell_nephropathy wikiPageWikiLink Hematoma.
- Sickle_cell_nephropathy wikiPageWikiLink Hematomas.
- Sickle_cell_nephropathy wikiPageWikiLink Hematuria.
- Sickle_cell_nephropathy wikiPageWikiLink Hydrogen.
- Sickle_cell_nephropathy wikiPageWikiLink Hyperfiltration_nephropathy.
- Sickle_cell_nephropathy wikiPageWikiLink Hyperkalemia.
- Sickle_cell_nephropathy wikiPageWikiLink Hyperperfusion.
- Sickle_cell_nephropathy wikiPageWikiLink Hypertonic.
- Sickle_cell_nephropathy wikiPageWikiLink Hyperuricemia.
- Sickle_cell_nephropathy wikiPageWikiLink Hypoxia_(medical).
- Sickle_cell_nephropathy wikiPageWikiLink Infarction.
- Sickle_cell_nephropathy wikiPageWikiLink Infarcts.
- Sickle_cell_nephropathy wikiPageWikiLink Infection.
- Sickle_cell_nephropathy wikiPageWikiLink Ischemia.
- Sickle_cell_nephropathy wikiPageWikiLink Ischemic.
- Sickle_cell_nephropathy wikiPageWikiLink Ischemic_injury.
- Sickle_cell_nephropathy wikiPageWikiLink Kidney.
- Sickle_cell_nephropathy wikiPageWikiLink Kidney_disease.
- Sickle_cell_nephropathy wikiPageWikiLink Kidney_failure.
- Sickle_cell_nephropathy wikiPageWikiLink Kidney_transplant.
- Sickle_cell_nephropathy wikiPageWikiLink Kidney_transplantation.
- Sickle_cell_nephropathy wikiPageWikiLink Mean_arterial_pressure.
- Sickle_cell_nephropathy wikiPageWikiLink Medical_grafting.
- Sickle_cell_nephropathy wikiPageWikiLink Metabolic_acidosis.
- Sickle_cell_nephropathy wikiPageWikiLink Microvasculature.
- Sickle_cell_nephropathy wikiPageWikiLink Microvessel.
- Sickle_cell_nephropathy wikiPageWikiLink Nephrogenic_diabetes_insipidus.
- Sickle_cell_nephropathy wikiPageWikiLink Nephron.
- Sickle_cell_nephropathy wikiPageWikiLink Nephropathy.
- Sickle_cell_nephropathy wikiPageWikiLink Nephrotic_syndrome.
- Sickle_cell_nephropathy wikiPageWikiLink Papillary_necrosis.
- Sickle_cell_nephropathy wikiPageWikiLink Pathologic.
- Sickle_cell_nephropathy wikiPageWikiLink Perinephric.
- Sickle_cell_nephropathy wikiPageWikiLink Phenotypic_trait.
- Sickle_cell_nephropathy wikiPageWikiLink Potassium.
- Sickle_cell_nephropathy wikiPageWikiLink Proteinuria.
- Sickle_cell_nephropathy wikiPageWikiLink Purine.
- Sickle_cell_nephropathy wikiPageWikiLink Red_blood_cell.
- Sickle_cell_nephropathy wikiPageWikiLink Red_blood_cells.
- Sickle_cell_nephropathy wikiPageWikiLink Renal_failure.
- Sickle_cell_nephropathy wikiPageWikiLink Renal_medulla.
- Sickle_cell_nephropathy wikiPageWikiLink Renal_papilla.
- Sickle_cell_nephropathy wikiPageWikiLink Renal_papillary_necrosis.
- Sickle_cell_nephropathy wikiPageWikiLink Renal_tubules.
- Sickle_cell_nephropathy wikiPageWikiLink Scar.
- Sickle_cell_nephropathy wikiPageWikiLink Scarred.
- Sickle_cell_nephropathy wikiPageWikiLink Sickle-cell_disease.
- Sickle_cell_nephropathy wikiPageWikiLink Sickle_cell_disease.
- Sickle_cell_nephropathy wikiPageWikiLink Straight_arterioles_of_kidney.
- Sickle_cell_nephropathy wikiPageWikiLink Thalassemia.
- Sickle_cell_nephropathy wikiPageWikiLink Tonicity.
- Sickle_cell_nephropathy wikiPageWikiLink Uremia.
- Sickle_cell_nephropathy wikiPageWikiLink Uric_acid.
- Sickle_cell_nephropathy wikiPageWikiLink Vasa_recta.
- Sickle_cell_nephropathy wikiPageWikiLinkText "Sickle cell nephropathy".
- Sickle_cell_nephropathy wikiPageWikiLinkText "sickle-cell nephropathy".
- Sickle_cell_nephropathy hasPhotoCollection Sickle_cell_nephropathy.
- Sickle_cell_nephropathy wikiPageUsesTemplate Template:Reflist.
- Sickle_cell_nephropathy subject Category:Kidney_diseases.
- Sickle_cell_nephropathy hypernym Nephropathy.
- Sickle_cell_nephropathy comment "Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease, it causes kidney complications as a result of sickling of red blood cells in the small blood vessels. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors sickling of red blood cells, with resultant local infarction (papillary necrosis).".
- Sickle_cell_nephropathy label "Sickle cell nephropathy".
- Sickle_cell_nephropathy sameAs m.05mx550.
- Sickle_cell_nephropathy sameAs Q7507640.
- Sickle_cell_nephropathy sameAs Q7507640.
- Sickle_cell_nephropathy wasDerivedFrom Sickle_cell_nephropathy?oldid=656029491.
- Sickle_cell_nephropathy isPrimaryTopicOf Sickle_cell_nephropathy.