Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Sialic_acid-binding_Ig-like_lectin_12> ?p ?o }
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- Sialic_acid-binding_Ig-like_lectin_12 abstract "Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.".
- Sialic_acid-binding_Ig-like_lectin_12 entrezgene "89858".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageID "14812422".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageLength "4978".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageOutDegree "11".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageRevisionID "679083323".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Gene.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Glycolipid.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Glycoprotein.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Immunoglobulin_superfamily.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Lectin.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Macrophage.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Protein.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Receptor_(biochemistry).
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLink Sialic_acid.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageWikiLinkText "Sialic acid-binding Ig-like lectin 12".
- Sialic_acid-binding_Ig-like_lectin_12 hasPhotoCollection Sialic_acid-binding_Ig-like_lectin_12.
- Sialic_acid-binding_Ig-like_lectin_12 requireManualInspection "no".
- Sialic_acid-binding_Ig-like_lectin_12 summaryText "Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.".
- Sialic_acid-binding_Ig-like_lectin_12 updateCitations "yes".
- Sialic_acid-binding_Ig-like_lectin_12 updatePage "yes".
- Sialic_acid-binding_Ig-like_lectin_12 updateProteinBox "yes".
- Sialic_acid-binding_Ig-like_lectin_12 updateSummary "yes".
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:Gene-19-stub.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:PBB.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:PBB_Controls.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:PBB_Further_reading.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:PBB_Summary.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:Refbegin.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:Refend.
- Sialic_acid-binding_Ig-like_lectin_12 wikiPageUsesTemplate Template:Reflist.
- Sialic_acid-binding_Ig-like_lectin_12 hypernym Protein.
- Sialic_acid-binding_Ig-like_lectin_12 type Article.
- Sialic_acid-binding_Ig-like_lectin_12 type Biomolecule.
- Sialic_acid-binding_Ig-like_lectin_12 type Protein.
- Sialic_acid-binding_Ig-like_lectin_12 type Article.
- Sialic_acid-binding_Ig-like_lectin_12 type Thing.
- Sialic_acid-binding_Ig-like_lectin_12 type Q206229.
- Sialic_acid-binding_Ig-like_lectin_12 type Q8054.
- Sialic_acid-binding_Ig-like_lectin_12 comment "Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs.".
- Sialic_acid-binding_Ig-like_lectin_12 label "Sialic acid-binding Ig-like lectin 12".
- Sialic_acid-binding_Ig-like_lectin_12 sameAs m.03gyrxc.
- Sialic_acid-binding_Ig-like_lectin_12 sameAs Q7506659.
- Sialic_acid-binding_Ig-like_lectin_12 sameAs Q7506659.
- Sialic_acid-binding_Ig-like_lectin_12 wasDerivedFrom Sialic_acid-binding_Ig-like_lectin_12?oldid=679083323.
- Sialic_acid-binding_Ig-like_lectin_12 isPrimaryTopicOf Sialic_acid-binding_Ig-like_lectin_12.