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- Sheddase abstract "Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface. Many sheddases are members of the ADAM or aspartic protease (BACE) protein families.These enzymes can activate a transmembrane protein if it is a receptor (e.g., HER2), or cut off the part of the transmembrane protein which has already bound an agonist (e.g., in the case of EGFR), allowing this agonist to go and stimulate a receptor on another cell. Hence, sheddases demultiply the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy.".
- Sheddase thumbnail Ectodomain_shedding_en.svg?width=300.
- Sheddase wikiPageID "7528603".
- Sheddase wikiPageLength "1370".
- Sheddase wikiPageOutDegree "13".
- Sheddase wikiPageRevisionID "544570329".
- Sheddase wikiPageWikiLink ADAM10.
- Sheddase wikiPageWikiLink ADAM17.
- Sheddase wikiPageWikiLink ADAM_protein.
- Sheddase wikiPageWikiLink A_disintegrin_and_metalloproteinase.
- Sheddase wikiPageWikiLink BACE.
- Sheddase wikiPageWikiLink Beta-secretase_1.
- Sheddase wikiPageWikiLink Category:EC_3.4.
- Sheddase wikiPageWikiLink Category:Membrane_proteins.
- Sheddase wikiPageWikiLink Ectodomain.
- Sheddase wikiPageWikiLink Ectodomain_shedding.
- Sheddase wikiPageWikiLink Enzyme.
- Sheddase wikiPageWikiLink Epidermal_growth_factor_receptor.
- Sheddase wikiPageWikiLink HER2.
- Sheddase wikiPageWikiLink neu.
- Sheddase wikiPageWikiLink Proteases_in_angiogenesis.
- Sheddase wikiPageWikiLink Transmembrane_protein.
- Sheddase wikiPageWikiLink File:Ectodomain_shedding_en.svg.
- Sheddase wikiPageWikiLinkText "sheddase".
- Sheddase hasPhotoCollection Sheddase.
- Sheddase wikiPageUsesTemplate Template:Hydrolase-stub.
- Sheddase wikiPageUsesTemplate Template:Membrane-protein-stub.
- Sheddase wikiPageUsesTemplate Template:Reflist.
- Sheddase wikiPageUsesTemplate Template:What.
- Sheddase subject Category:EC_3.4.
- Sheddase subject Category:Membrane_proteins.
- Sheddase hypernym Enzymes.
- Sheddase type Article.
- Sheddase type Biomolecule.
- Sheddase type Article.
- Sheddase comment "Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface.".
- Sheddase label "Sheddase".
- Sheddase sameAs Sheddase.
- Sheddase sameAs m.0264fq8.
- Sheddase sameAs Шеддазы.
- Sheddase sameAs Q426772.
- Sheddase sameAs Q426772.
- Sheddase wasDerivedFrom Sheddase?oldid=544570329.
- Sheddase depiction Ectodomain_shedding_en.svg.
- Sheddase isPrimaryTopicOf Sheddase.