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- Sf_caspase-1 abstract "The protein Sf caspase-1 is the insect ortholog of the human effector caspases CASP3 (CPP32) and CASP7 (MCH3) in the species Spodoptera frugiperda (Fall armyworm). It was identified as the target of the baculoviral caspase inhibitor protein P35, which it cleaves and by which it is inhibited. Like other caspases, Sf caspase-1 is an aspartate-specific cysteine protease that is produced as an inactive proenzyme and becomes activated by autocatalytic cleavage. The Sf caspase-1 proenzyme is cleaved after the amino acid residues Asp-28 and Asp-195, resulting in a smaller 12 kDa fragment and a larger 19 kDa fragment. Just like with human caspases CASP3 or CASP7, the two cleavage fragments form heterodimers, which again form biologically active dimers-of-heterodimers consisting of two smaller and two larger fragments. Some experiments also showed cleavage of Sf caspase-1 at the residue Asp-184, resulting in a 18 kDa instead of 19 kDa fragment, however this result is likely an in vitro artefact. The insect immunophilin FKBP46 is a substrate of Sf caspase-1, which cleaves full length FKBP46 (~46 kDa) resulting in a ~25 kDa fragment.".
- Sf_caspase-1 thumbnail Sf_caspase-1_structure_by_Ni_2006,_PDB_2NN3.jpg?width=300.
- Sf_caspase-1 wikiPageID "47189627".
- Sf_caspase-1 wikiPageLength "2960".
- Sf_caspase-1 wikiPageOutDegree "18".
- Sf_caspase-1 wikiPageRevisionID "676547218".
- Sf_caspase-1 wikiPageWikiLink Atomic_mass_unit.
- Sf_caspase-1 wikiPageWikiLink Autocatalytic_reaction.
- Sf_caspase-1 wikiPageWikiLink Baculoviridae.
- Sf_caspase-1 wikiPageWikiLink Baculovirus.
- Sf_caspase-1 wikiPageWikiLink Bond_cleavage.
- Sf_caspase-1 wikiPageWikiLink CASP3.
- Sf_caspase-1 wikiPageWikiLink CASP7.
- Sf_caspase-1 wikiPageWikiLink Caspase.
- Sf_caspase-1 wikiPageWikiLink Caspase_3.
- Sf_caspase-1 wikiPageWikiLink Caspase_7.
- Sf_caspase-1 wikiPageWikiLink Category:Animal_proteins.
- Sf_caspase-1 wikiPageWikiLink Category:Apoptosis.
- Sf_caspase-1 wikiPageWikiLink Category:EC_3.4.22.
- Sf_caspase-1 wikiPageWikiLink Cysteine_protease.
- Sf_caspase-1 wikiPageWikiLink Early_35_kDa_protein.
- Sf_caspase-1 wikiPageWikiLink Effector_caspase.
- Sf_caspase-1 wikiPageWikiLink FKBP46.
- Sf_caspase-1 wikiPageWikiLink Fall_armyworm.
- Sf_caspase-1 wikiPageWikiLink Homology_(biology).
- Sf_caspase-1 wikiPageWikiLink Immunophilin.
- Sf_caspase-1 wikiPageWikiLink Immunophilins.
- Sf_caspase-1 wikiPageWikiLink In_vitro.
- Sf_caspase-1 wikiPageWikiLink Kilodalton.
- Sf_caspase-1 wikiPageWikiLink Ortholog.
- Sf_caspase-1 wikiPageWikiLink Proenzyme.
- Sf_caspase-1 wikiPageWikiLink Zymogen.
- Sf_caspase-1 wikiPageWikiLinkText "Sf caspase-1".
- Sf_caspase-1 caption "Sf caspase-1 structure by Ni et al. 2006".
- Sf_caspase-1 hasPhotoCollection Sf_caspase-1.
- Sf_caspase-1 name "Sf caspase-1".
- Sf_caspase-1 organism "Spodoptera frugiperda".
- Sf_caspase-1 pdb "2".
- Sf_caspase-1 refseqmrna "U81510.1".
- Sf_caspase-1 refseqprotein "AAC47442.1".
- Sf_caspase-1 symbol "N/A".
- Sf_caspase-1 taxid "7108".
- Sf_caspase-1 uniprot "P89116".
- Sf_caspase-1 wikiPageUsesTemplate Template:Infobox_nonhuman_protein.
- Sf_caspase-1 wikiPageUsesTemplate Template:Reflist.
- Sf_caspase-1 subject Category:Animal_proteins.
- Sf_caspase-1 subject Category:Apoptosis.
- Sf_caspase-1 subject Category:EC_3.4.22.
- Sf_caspase-1 hypernym Ortholog.
- Sf_caspase-1 comment "The protein Sf caspase-1 is the insect ortholog of the human effector caspases CASP3 (CPP32) and CASP7 (MCH3) in the species Spodoptera frugiperda (Fall armyworm). It was identified as the target of the baculoviral caspase inhibitor protein P35, which it cleaves and by which it is inhibited. Like other caspases, Sf caspase-1 is an aspartate-specific cysteine protease that is produced as an inactive proenzyme and becomes activated by autocatalytic cleavage.".
- Sf_caspase-1 label "Sf caspase-1".
- Sf_caspase-1 wasDerivedFrom Sf_caspase-1?oldid=676547218.
- Sf_caspase-1 depiction Sf_caspase-1_structure_by_Ni_2006,_PDB_2NN3.jpg.
- Sf_caspase-1 isPrimaryTopicOf Sf_caspase-1.