Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Serpin> ?p ?o }
- Serpin abstract "Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors).The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation (e.g. Figure 1) and inflammation, respectively. Initially, research focused upon their role in human disease: antithrombin deficiency results in thrombosis and antitrypsin deficiency causes emphysema. In 1980 Hunt and Dayhoff made the surprising discovery that both these molecules share significant amino acid sequence similarity to the major protein in chicken egg white, ovalbumin, and they proposed a new protein superfamily. Over 1000 serpins have now been identified, these include 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors.While most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and molecular chaperones (HSP47). The term serpin is used to describe these latter members as well, despite their noninhibitory function.As serpins control processes such as coagulation and inflammation, these proteins are the target of medical research. However, serpins are also of particular interest to the structural biology and protein folding communities, because they undergo a unique and dramatic change in shape (or conformational change) when they inhibit target proteases. This is unusual — most classical protease inhibitors function as simple "lock and key" molecules that bind to and block access to the protease active site (see, for example, bovine pancreatic trypsin inhibitor). While the serpin mechanism of protease inhibition confers certain advantages, it also has drawbacks, and serpins are vulnerable to mutations that result in protein misfolding and the formation of inactive long-chain polymers (serpinopathies). Serpin polymerisation reduces the amount of active inhibitor, as well as accumulation of serpin polymers, causing cell death and organ failure. For example, the serpin antitrypsin is primarily produced in the liver, and antitrypsin polymerisation causes liver cirrhosis. Understanding serpinopathies also provides insights on protein misfolding in general, a process common to many human diseases, such as Alzheimer's and Creutzfeldt-Jakob disease.".
- Serpin symbol "Serpin".
- Serpin thumbnail Proteinzcomplex.png?width=300.
- Serpin wikiPageExternalLink huntingtonlab.cimr.cam.ac.uk.
- Serpin wikiPageExternalLink movies.html.
- Serpin wikiPageExternalLink merops.sanger.ac.uk.
- Serpin wikiPageExternalLink index.htm.
- Serpin wikiPageExternalLink %7Efcc.
- Serpin wikiPageExternalLink www.alphaone.org.
- Serpin wikiPageExternalLink troberts.html.
- Serpin wikiPageExternalLink viewer.fcgi?db=nuccore&id=47125085.
- Serpin wikiPageExternalLink structidSearch.do?structureId=2ZNH.
- Serpin wikiPageExternalLink www.pymol.org.
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- Serpin wikiPageExternalLink structidSearch.do?structureId=3B9F.
- Serpin wikiPageExternalLink fluhr.
- Serpin wikiPageExternalLink whisstock-lab.med.monash.edu.au.
- Serpin wikiPageID "564590".
- Serpin wikiPageLength "128646".
- Serpin wikiPageOutDegree "284".
- Serpin wikiPageRevisionID "679082285".
- Serpin wikiPageWikiLink 47_kDa_Heat_shock_protein.
- Serpin wikiPageWikiLink Active_site.
- Serpin wikiPageWikiLink Alpha-1_antitrypsin.
- Serpin wikiPageWikiLink Alpha_1-antichymotrypsin.
- Serpin wikiPageWikiLink Alpha_1-antitrypsin.
- Serpin wikiPageWikiLink Alpha_1-antitrypsin_deficiency.
- Serpin wikiPageWikiLink Alpha_2-antiplasmin.
- Serpin wikiPageWikiLink Alpha_helix.
- Serpin wikiPageWikiLink Alzheimers.
- Serpin wikiPageWikiLink Alzheimers_disease.
- Serpin wikiPageWikiLink Amino_acid.
- Serpin wikiPageWikiLink Amino_acids.
- Serpin wikiPageWikiLink Angioedema.
- Serpin wikiPageWikiLink Angiotensin.
- Serpin wikiPageWikiLink Angiotensin_I.
- Serpin wikiPageWikiLink Angiotensinogen.
- Serpin wikiPageWikiLink Anticoagulant.
- Serpin wikiPageWikiLink Antigen.
- Serpin wikiPageWikiLink Antithrombin.
- Serpin wikiPageWikiLink Antithrombin_III_deficiency.
- Serpin wikiPageWikiLink Antithrombin_deficiency.
- Serpin wikiPageWikiLink Antitrypsin.
- Serpin wikiPageWikiLink Antitrypsin-related_protein.