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- Serine_hydrolase abstract "The serine hydrolase superfamily is one of the largest known enzyme families comprising approximately ~200 enzymes or 1% of the genes in the human proteome. A characteristic defining feature of this superfamily is the presence of an active site nucleophilic serine that is used for the hydrolysis of substrates. Catalysis proceeds by the formation of an acyl-enzyme intermediate through this serine, followed by water/hydroxide-induced saponification of the intermediate and regeneration of the enzyme. Unlike other non-catalytic serines, the nucleophilic serine of these hydrolases is typically activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine) although variations on this mechanism exist.This family includes: serine proteases, including trypsin, chymotrypsin, and subtilisin Extracellular lipases, including pancreatic lipase, hepatic lipase, gastric lipase, endothelial lipase, and lipoprotein lipase Intracellular lipases, including hormone sensitive lipase, monoacylglycerol lipase, adipose triglyceride lipase, and diacylglycerol lipase Cholinesterases, including acetylcholinesterase and butyrylcholinesterase Small molecule thioesterases, including fatty acid synthase and the acyl-CoA thioesterases Some phospholipases, including phospholipase A2 and platelet activating factor acetylhydrolase Protein and glycan hydrolases, including protein phosphate methylesterase 1, acyloxyacyl hydrolase and sialic acid acetylesterase Some amidases, including fatty acid amide hydrolase Some peptidases, including dipeptidyl peptidase 4, fibroblast activation protein, and prolylendopeptidase↑".
- Serine_hydrolase wikiPageID "10227965".
- Serine_hydrolase wikiPageLength "2509".
- Serine_hydrolase wikiPageOutDegree "53".
- Serine_hydrolase wikiPageRevisionID "619651991".
- Serine_hydrolase wikiPageWikiLink ACOT2.
- Serine_hydrolase wikiPageWikiLink Acetylcholinesterase.
- Serine_hydrolase wikiPageWikiLink Active_site.
- Serine_hydrolase wikiPageWikiLink Activity-based_proteomics.
- Serine_hydrolase wikiPageWikiLink Activity_based_proteomics.
- Serine_hydrolase wikiPageWikiLink Acyloxyacyl_hydrolase.
- Serine_hydrolase wikiPageWikiLink Adipose_triglyceride_lipase.
- Serine_hydrolase wikiPageWikiLink beta_hydrolase_fold.
- Serine_hydrolase wikiPageWikiLink Amidase.
- Serine_hydrolase wikiPageWikiLink Amide.
- Serine_hydrolase wikiPageWikiLink Aspartate.
- Serine_hydrolase wikiPageWikiLink Aspartic_acid.
- Serine_hydrolase wikiPageWikiLink Butyrylcholinesterase.
- Serine_hydrolase wikiPageWikiLink Catalysis.
- Serine_hydrolase wikiPageWikiLink Category:EC_3.1.
- Serine_hydrolase wikiPageWikiLink Category:Hydrolases.
- Serine_hydrolase wikiPageWikiLink Cholinesterase.
- Serine_hydrolase wikiPageWikiLink Chymotrypsin.
- Serine_hydrolase wikiPageWikiLink Diacylglycerol_lipase.
- Serine_hydrolase wikiPageWikiLink Dipeptidyl_peptidase-4.
- Serine_hydrolase wikiPageWikiLink Dipeptidyl_peptidase_4.
- Serine_hydrolase wikiPageWikiLink Endothelial_lipase.
- Serine_hydrolase wikiPageWikiLink Enzyme.
- Serine_hydrolase wikiPageWikiLink Ester.
- Serine_hydrolase wikiPageWikiLink Fatty_acid_amide_hydrolase.
- Serine_hydrolase wikiPageWikiLink Fatty_acid_synthase.
- Serine_hydrolase wikiPageWikiLink Fibroblast_activation_protein.
- Serine_hydrolase wikiPageWikiLink Fibroblast_activation_protein,_alpha.
- Serine_hydrolase wikiPageWikiLink Gastric_lipase.
- Serine_hydrolase wikiPageWikiLink Glutamate.
- Serine_hydrolase wikiPageWikiLink Glutamic_acid.
- Serine_hydrolase wikiPageWikiLink Glycan.
- Serine_hydrolase wikiPageWikiLink Hepatic_lipase.
- Serine_hydrolase wikiPageWikiLink Histidine.
- Serine_hydrolase wikiPageWikiLink Hormone-sensitive_lipase.
- Serine_hydrolase wikiPageWikiLink Hormone_sensitive_lipase.
- Serine_hydrolase wikiPageWikiLink Hydrolysis.
- Serine_hydrolase wikiPageWikiLink Lipase.
- Serine_hydrolase wikiPageWikiLink Lipoprotein-associated_phospholipase_A2.
- Serine_hydrolase wikiPageWikiLink Lipoprotein_lipase.
- Serine_hydrolase wikiPageWikiLink List_of_enzymes.
- Serine_hydrolase wikiPageWikiLink Monoacylglycerol_lipase.
- Serine_hydrolase wikiPageWikiLink Nucleophile.
- Serine_hydrolase wikiPageWikiLink Nucleophilic.
- Serine_hydrolase wikiPageWikiLink PAF-AH.
- Serine_hydrolase wikiPageWikiLink PNPLA2.
- Serine_hydrolase wikiPageWikiLink Pancreatic_lipase.
- Serine_hydrolase wikiPageWikiLink Phospholipase.
- Serine_hydrolase wikiPageWikiLink Phospholipase_A2.
- Serine_hydrolase wikiPageWikiLink Prolyl_endopeptidase.
- Serine_hydrolase wikiPageWikiLink Protein.
- Serine_hydrolase wikiPageWikiLink Proton_relay.
- Serine_hydrolase wikiPageWikiLink Saponification.
- Serine_hydrolase wikiPageWikiLink Serine.
- Serine_hydrolase wikiPageWikiLink Serine_protease.
- Serine_hydrolase wikiPageWikiLink Sialic_acid_acetylesterase.
- Serine_hydrolase wikiPageWikiLink Substrate_(biochemistry).
- Serine_hydrolase wikiPageWikiLink Substrate_(chemistry).
- Serine_hydrolase wikiPageWikiLink Subtilisin.
- Serine_hydrolase wikiPageWikiLink Thioester.
- Serine_hydrolase wikiPageWikiLink Thioesterase.
- Serine_hydrolase wikiPageWikiLink Trypsin.
- Serine_hydrolase wikiPageWikiLinkText "Serine hydrolase".
- Serine_hydrolase wikiPageWikiLinkText "serine hydrolase".
- Serine_hydrolase hasPhotoCollection Serine_hydrolase.
- Serine_hydrolase wikiPageUsesTemplate Template:Enzymes.
- Serine_hydrolase wikiPageUsesTemplate Template:Esterases.
- Serine_hydrolase wikiPageUsesTemplate Template:Reflist.
- Serine_hydrolase subject Category:EC_3.1.
- Serine_hydrolase subject Category:Hydrolases.
- Serine_hydrolase hypernym Families.
- Serine_hydrolase type Mollusca.
- Serine_hydrolase comment "The serine hydrolase superfamily is one of the largest known enzyme families comprising approximately ~200 enzymes or 1% of the genes in the human proteome. A characteristic defining feature of this superfamily is the presence of an active site nucleophilic serine that is used for the hydrolysis of substrates.".
- Serine_hydrolase label "Serine hydrolase".
- Serine_hydrolase sameAs Hidrolasa_serina.
- Serine_hydrolase sameAs m.02q5x7c.
- Serine_hydrolase sameAs Q7454849.
- Serine_hydrolase sameAs Q7454849.
- Serine_hydrolase wasDerivedFrom Serine_hydrolase?oldid=619651991.
- Serine_hydrolase isPrimaryTopicOf Serine_hydrolase.