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- Semisynthesis abstract "Semisynthesis or partial chemical synthesis is a type of chemical synthesis that uses compounds isolated from natural sources (e.g. plant material or bacterial or cell cultures) as starting materials. These natural biomolecules are often large and complex molecules. This is opposed to a total synthesis where large molecules are synthesized through a stepwise combination of small and inexpensive (usually petrochemical) building blocks.Semisynthesis is usually used when the precursor molecule is too structurally complex, too costly, or too difficult to be produced by total synthesis. From a synthesis viewpoint, life is capable of biosynthesizing structurally complex chemical compound. In some cases, with a small agricultural investment, a plant can be grown to produce chemical intermediates that chemical synthesis would struggle to produce. Elaboration of these intermediates with synthetic chemistry can then cost-effectively provide the complex final targets.Drugs derived from natural sources are usually produced by harvesting the natural source or through semisynthetic methods: one example is the semisynthesis of LSD from ergotamine, which is isolated from ergot fungus cultures. The commercial production of paclitaxel is also based on semisynthesis (see paclitaxel total synthesis). The antimalarial drug artemether (a component of Coartem) is a semisynthetic drug derived from naturally occurring artemisinin. Artemisinin contains an undesirable lactone group and which is replaced by an acetal through organic reduction with potassium borohydride and methoxylation:Artemether semisynthesis from artemisinin↑".
- Semisynthesis thumbnail ArtemetherSynthesis.png?width=300.
- Semisynthesis wikiPageID "782890".
- Semisynthesis wikiPageLength "2275".
- Semisynthesis wikiPageOutDegree "31".
- Semisynthesis wikiPageRevisionID "681336455".
- Semisynthesis wikiPageWikiLink Acetal.
- Semisynthesis wikiPageWikiLink Artemether.
- Semisynthesis wikiPageWikiLink lumefantrine.
- Semisynthesis wikiPageWikiLink Artemisinin.
- Semisynthesis wikiPageWikiLink Bacteria.
- Semisynthesis wikiPageWikiLink Biomolecule.
- Semisynthesis wikiPageWikiLink Biosynthesis.
- Semisynthesis wikiPageWikiLink Borohydride.
- Semisynthesis wikiPageWikiLink Category:Chemical_synthesis.
- Semisynthesis wikiPageWikiLink Category:Medicinal_chemistry.
- Semisynthesis wikiPageWikiLink Cell_culture.
- Semisynthesis wikiPageWikiLink Chemical_synthesis.
- Semisynthesis wikiPageWikiLink Coartem.
- Semisynthesis wikiPageWikiLink Drug_development.
- Semisynthesis wikiPageWikiLink Drug_discovery.
- Semisynthesis wikiPageWikiLink Ergot.
- Semisynthesis wikiPageWikiLink Ergotamine.
- Semisynthesis wikiPageWikiLink Fungus.
- Semisynthesis wikiPageWikiLink LSD.
- Semisynthesis wikiPageWikiLink Lactone.
- Semisynthesis wikiPageWikiLink Life.
- Semisynthesis wikiPageWikiLink Lysergic_acid_diethylamide.
- Semisynthesis wikiPageWikiLink Methoxy.
- Semisynthesis wikiPageWikiLink Molecule.
- Semisynthesis wikiPageWikiLink Natural_product.
- Semisynthesis wikiPageWikiLink Natural_source.
- Semisynthesis wikiPageWikiLink Organic_redox_reaction.
- Semisynthesis wikiPageWikiLink Organic_reduction.
- Semisynthesis wikiPageWikiLink Paclitaxel.
- Semisynthesis wikiPageWikiLink Paclitaxel_total_synthesis.
- Semisynthesis wikiPageWikiLink Plant.
- Semisynthesis wikiPageWikiLink Reactant.
- Semisynthesis wikiPageWikiLink Reagent.
- Semisynthesis wikiPageWikiLink Total_synthesis.
- Semisynthesis wikiPageWikiLink File:ArtemetherSynthesis.png.
- Semisynthesis wikiPageWikiLinkText "Semisynthesis".
- Semisynthesis wikiPageWikiLinkText "semi-synthesis".
- Semisynthesis wikiPageWikiLinkText "semi-synthetic".
- Semisynthesis wikiPageWikiLinkText "semi-synthetically".
- Semisynthesis wikiPageWikiLinkText "semisyntheses".
- Semisynthesis wikiPageWikiLinkText "semisynthesis".
- Semisynthesis wikiPageWikiLinkText "semisynthesized".
- Semisynthesis wikiPageWikiLinkText "semisynthetic".
- Semisynthesis hasPhotoCollection Semisynthesis.
- Semisynthesis wikiPageUsesTemplate Template:Chemical_synthesis.
- Semisynthesis wikiPageUsesTemplate Template:Reflist.
- Semisynthesis subject Category:Chemical_synthesis.
- Semisynthesis subject Category:Medicinal_chemistry.
- Semisynthesis hypernym Synthesis.
- Semisynthesis type ProgrammingLanguage.
- Semisynthesis type Process.
- Semisynthesis type Reaction.
- Semisynthesis type Science.
- Semisynthesis comment "Semisynthesis or partial chemical synthesis is a type of chemical synthesis that uses compounds isolated from natural sources (e.g. plant material or bacterial or cell cultures) as starting materials. These natural biomolecules are often large and complex molecules.".
- Semisynthesis label "Semisynthesis".
- Semisynthesis sameAs Semisíntesi.
- Semisynthesis sameAs Partialsynthese.
- Semisynthesis sameAs Poolsüntees.
- Semisynthesis sameAs Hémisynthèse.
- Semisynthesis sameAs 半合成.
- Semisynthesis sameAs Semisynthese.
- Semisynthesis sameAs Semissíntese.
- Semisynthesis sameAs m.03c0ky.
- Semisynthesis sameAs Polusinteza.
- Semisynthesis sameAs Polusinteza.
- Semisynthesis sameAs Q901154.
- Semisynthesis sameAs Q901154.
- Semisynthesis sameAs 半合成.
- Semisynthesis wasDerivedFrom Semisynthesis?oldid=681336455.
- Semisynthesis depiction ArtemetherSynthesis.png.
- Semisynthesis isPrimaryTopicOf Semisynthesis.