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- Sema_domain abstract "The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins.CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23.The Sema domain is characterised by a conserved set of cysteine residues, which form four disulfide bonds to stabilise the structure. The Sema domain fold is a variation of the beta propeller topology, with seven blades radiallyarranged around a central axis. Each blade contains a four- stranded (strands A to D) antiparallel beta sheet. The inner strand of each blade (A) lines the channel at the centre of the propeller, with strands B and C of the same repeat radiating outward, and strand D of the next repeat forming the outer edge of the blade. The large size of the Sema domain is not due to a single inserted domain but results from the presence of additional secondary structure elements inserted in most of the blades. The Sema domain uses a 'loop and hook' system to close the circle between the first and the last blades. The blades are constructed sequentially with an N-terminal beta- strand closing the circle by providing the outermost strand (D) of the seventh (C-terminal) blade. The beta-propeller is further stabilized by an extension of the N-terminus, providing an additional, fifth beta-strand on the outer edge of blade 6.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).".
- Sema_domain symbol "Sema".
- Sema_domain thumbnail PBB_Protein_SEMA3A_image.jpg?width=300.
- Sema_domain wikiPageExternalLink )..
- Sema_domain wikiPageID "14693740".
- Sema_domain wikiPageLength "4390".
- Sema_domain wikiPageOutDegree "41".
- Sema_domain wikiPageRevisionID "601216747".
- Sema_domain wikiPageWikiLink Axon_guidance.
- Sema_domain wikiPageWikiLink B_cell.
- Sema_domain wikiPageWikiLink C-Met.
- Sema_domain wikiPageWikiLink CD23.
- Sema_domain wikiPageWikiLink Category:Protein_domains.
- Sema_domain wikiPageWikiLink Category:Protein_families.
- Sema_domain wikiPageWikiLink Category:Single-pass_transmembrane_proteins.
- Sema_domain wikiPageWikiLink MST1R.
- Sema_domain wikiPageWikiLink PLXNA1.
- Sema_domain wikiPageWikiLink PLXNA2.
- Sema_domain wikiPageWikiLink PLXNA3.
- Sema_domain wikiPageWikiLink PLXNA4.
- Sema_domain wikiPageWikiLink PLXNB1.
- Sema_domain wikiPageWikiLink PLXNB2.
- Sema_domain wikiPageWikiLink PLXNB3.
- Sema_domain wikiPageWikiLink PLXND1.
- Sema_domain wikiPageWikiLink PTPase.
- Sema_domain wikiPageWikiLink Plexin_A1.
- Sema_domain wikiPageWikiLink Protein_domain.
- Sema_domain wikiPageWikiLink Protein_family.
- Sema_domain wikiPageWikiLink Protein_kinase.
- Sema_domain wikiPageWikiLink SEMA3A.
- Sema_domain wikiPageWikiLink SEMA3B.
- Sema_domain wikiPageWikiLink SEMA3C.
- Sema_domain wikiPageWikiLink SEMA3D.
- Sema_domain wikiPageWikiLink SEMA3E.
- Sema_domain wikiPageWikiLink SEMA3F.
- Sema_domain wikiPageWikiLink SEMA3G.
- Sema_domain wikiPageWikiLink SEMA4A.
- Sema_domain wikiPageWikiLink SEMA4B.
- Sema_domain wikiPageWikiLink SEMA4C.
- Sema_domain wikiPageWikiLink SEMA4D.
- Sema_domain wikiPageWikiLink SEMA4F.
- Sema_domain wikiPageWikiLink SEMA4G.
- Sema_domain wikiPageWikiLink SEMA5A.
- Sema_domain wikiPageWikiLink SEMA5B.
- Sema_domain wikiPageWikiLink SEMA6A.
- Sema_domain wikiPageWikiLink SEMA6B.
- Sema_domain wikiPageWikiLink SEMA6C.
- Sema_domain wikiPageWikiLink SEMA6D.
- Sema_domain wikiPageWikiLink SEMA7A.
- Sema_domain wikiPageWikiLink Semaphorin.
- Sema_domain wikiPageWikiLink Serine_kinase.
- Sema_domain wikiPageWikiLink Structural_domain.
- Sema_domain wikiPageWikiLinkText "Sema domain".
- Sema_domain wikiPageWikiLinkText "sema domain".
- Sema_domain caption "Sema domain, immunoglobulin domain , short basic domain".
- Sema_domain hasPhotoCollection Sema_domain.
- Sema_domain interpro "IPR001627".
- Sema_domain pdb "B:55-500 A:55-500 A:50-482 A:57-498".
- Sema_domain pfam "PF01403".
- Sema_domain prosite "PDOC51004".
- Sema_domain scop "1".
- Sema_domain symbol "Sema".
- Sema_domain width "250".
- Sema_domain wikiPageUsesTemplate Template:InterPro_content.
- Sema_domain wikiPageUsesTemplate Template:Pfam_box.
- Sema_domain wikiPageUsesTemplate Template:Reflist.
- Sema_domain wikiPageUsesTemplate Template:Uniprot.
- Sema_domain subject Category:Protein_domains.
- Sema_domain subject Category:Protein_families.
- Sema_domain subject Category:Single-pass_transmembrane_proteins.
- Sema_domain hypernym Domain.
- Sema_domain type Biomolecule.
- Sema_domain type Protein.
- Sema_domain type Chemical.
- Sema_domain type Domain.
- Sema_domain type Thing.
- Sema_domain type Q206229.
- Sema_domain type Q8054.
- Sema_domain comment "The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins.CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity.".
- Sema_domain label "Sema domain".
- Sema_domain sameAs m.03gtb1_.
- Sema_domain sameAs Q7448981.
- Sema_domain sameAs Q7448981.
- Sema_domain wasDerivedFrom Sema_domain?oldid=601216747.
- Sema_domain depiction PBB_Protein_SEMA3A_image.jpg.
- Sema_domain isPrimaryTopicOf Sema_domain.