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- Self-microemulsifying_drug_delivery_system abstract "A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling. It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant potential for use in drug delivery, and SMEDDS (including so-called "U-type" microemulsions) are the best of these systems identified to date. SMEDDS are of particular value in increasing the absorption of lipophilic drugs taken by mouth.SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, tacrolimus, berberine hydrochloride, nobiletin, piroxicam, anti-malaria drugs beta-Artemether and halofantrine, anti-HIV drug UC 781, nimodipine, exemestane, anti-cancer drugs 9-nitrocamptothecin (9-NC) paclitaxel, and seocalcitol, alprostadil (intraurethral use), probucol, itraconazole, fenofibrate, acyclovir, simvastatin, xibornol, silymarin, alpha-asarone, enilconazole, puerarin (an isoflavone found in Pueraria lobata), atorvastatin, heparin, carvedilol, ketoconazole, gentamicin, labrasol, flurbiprofen, celecoxib, danazol, cyclosporine, and idebenone.Actual applications of Self-microemulsifying drug delivery system' (SMEDDS) remain rare. The first drug marketed as a SMEDDS was cyclosporin, and it had significantly improved bioavailability compared with the conventional solution. In the last decade, several SMEDDS loaded with antiviral drugs (ritonavir, saquinavir) were tested for treatment of HIV infection, but the relative improvement in clinical benefit was not significant. The SMEDDS formulation of ritonavir (soft capsules) has been withdrawn in some countries.SMEDDS offer numerous advantages: spontaneous formation, ease of manufacture, thermodynamic stability, and improved solubilization of bioactive materials. Improved solubility contributes to faster release rates and greater bioavailability. For many drugs taken by mouth, faster release rates improve the drug acceptance by consumers. Greater bioavailability means that less drug need be used; this may lower cost, and does lower the stomach irritation and toxicity of drugs taken by mouth.For oral use, SMEDDS may be formulated as liquids or solids, the solids packaged in capsules or tablets. Limited studies comparing these report that in terms of bioavailability liquid SMEDDS are superior to solid SMEDDS, which are superior to conventional tablets. Liquid SMEDDS have also shown value in injectable (IV and urethral) formulations and in a topical (oral) spray.".
- Self-microemulsifying_drug_delivery_system wikiPageExternalLink article.asp?issn=0973-8398;year=2015;volume=9;issue=1;spage=13;epage=18;aulast=Singh.
- Self-microemulsifying_drug_delivery_system wikiPageExternalLink 17425247.2015.999038.
- Self-microemulsifying_drug_delivery_system wikiPageExternalLink S0032591014008870.
- Self-microemulsifying_drug_delivery_system wikiPageID "21869194".
- Self-microemulsifying_drug_delivery_system wikiPageLength "26746".
- Self-microemulsifying_drug_delivery_system wikiPageOutDegree "59".
- Self-microemulsifying_drug_delivery_system wikiPageRevisionID "679425800".
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink 9-nitrocamptothecin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Aciclovir.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Acyclovir.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Alprostadil.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Anethole.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Anethole_trithione.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Anise.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Asarone.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Atorvastatin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Berberine.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Beta-Artemether.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Cancer.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Carvedilol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Category:Dosage_forms.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Category:Drug_delivery_devices.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Celecoxib.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Ciclosporin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Curcumin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Cyclosporin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Cyclosporine.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Danazol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Distilled_beverage.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Drug_delivery.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Enilconazole.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Excipient.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Exemestane.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Fenofibrate.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Flurbiprofen.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Gentamicin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink HIV.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Halofantrine.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Heparin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Hydrochloride.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Idebenone.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Isoflavone.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Isoflavones.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Itraconazole.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Ketoconazole.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Labrasol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Lipophilicity.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Liquor.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Malaria.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Microemulsion.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Nimodipine.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Nobiletin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Oridonin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Ouzo_effect.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Paclitaxel.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Piroxicam.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Probucol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Prostaglandin_E1.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Pueraria_lobata.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Pueraria_montana.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Puerarin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Ritonavir.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Saquinavir.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Seocalcitol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Silibinin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Silymarin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Simvastatin.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Tacrolimus.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink UC_781.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Urethra.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Vinpocetine.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLink Xibornol.
- Self-microemulsifying_drug_delivery_system wikiPageWikiLinkText "Self-microemulsifying drug delivery system".
- Self-microemulsifying_drug_delivery_system wikiPageWikiLinkText "self-microemulsifying drug delivery system".
- Self-microemulsifying_drug_delivery_system hasPhotoCollection Self-microemulsifying_drug_delivery_system.
- Self-microemulsifying_drug_delivery_system wikiPageUsesTemplate Template:Doi.
- Self-microemulsifying_drug_delivery_system wikiPageUsesTemplate Template:Dosage_forms.
- Self-microemulsifying_drug_delivery_system wikiPageUsesTemplate Template:Reflist.
- Self-microemulsifying_drug_delivery_system subject Category:Dosage_forms.
- Self-microemulsifying_drug_delivery_system subject Category:Drug_delivery_devices.
- Self-microemulsifying_drug_delivery_system hypernym System.
- Self-microemulsifying_drug_delivery_system type Article.
- Self-microemulsifying_drug_delivery_system type Drug.
- Self-microemulsifying_drug_delivery_system type Article.
- Self-microemulsifying_drug_delivery_system type Drug.
- Self-microemulsifying_drug_delivery_system comment "A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling. It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors.".
- Self-microemulsifying_drug_delivery_system label "Self-microemulsifying drug delivery system".
- Self-microemulsifying_drug_delivery_system sameAs m.05p0fpk.
- Self-microemulsifying_drug_delivery_system sameAs Q7448149.
- Self-microemulsifying_drug_delivery_system sameAs Q7448149.
- Self-microemulsifying_drug_delivery_system wasDerivedFrom Self-microemulsifying_drug_delivery_system?oldid=679425800.
- Self-microemulsifying_drug_delivery_system isPrimaryTopicOf Self-microemulsifying_drug_delivery_system.