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- Self-complementary_adeno-associated_virus_(scAAV) abstract "Self-complementary adeno-associated virus (scAAV) is a viral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. Use of recombinant AAV (rAAV) has been successful in clinical trials addressing a variety of diseases. This lab-made progeny of rAAV is termed "self-complementary" because the coding region has been designed to form an intra-molecular double-stranded DNA template. A rate-limiting step for the standard AAV genome involves the second-strand synthesis since the typical AAV genome is a single-stranded DNA template. However, this is not the case for scAAV genomes. Upon infection, rather than waiting for cell mediated synthesis of the second strand, the two complementary halves of scAAV will associate to form one double stranded DNA (dsDNA) unit that is ready for immediate replication and transcription. The caveat of this construct is that instead of the full coding capacity found in rAAV (4.7-6kb) scAAV can only hold about half of that amount (≈2.4kb).In gene therapy application utilizing rAAV, the virus transduces the cell with a single stranded DNA (ssDNA) flanked by two Inverted Terminal Repeats (ITRs). These ITRs form hairpins at the end of the sequence to serve as primers to initiate synthesis of the second strand before subsequent steps of infection can begin. The second strand synthesis is considered to be one of several blocks to efficient infection. Additional advantages of scAAV include increased and prolonged transgene expression in vitro and in vivo, as well as "higher in vivo DNA stability and more effective circularization."".
- Self-complementary_adeno-associated_virus_(scAAV) colourName "violet".
- Self-complementary_adeno-associated_virus_(scAAV) family Parvoviridae.
- Self-complementary_adeno-associated_virus_(scAAV) family Parvovirinae.
- Self-complementary_adeno-associated_virus_(scAAV) genus Dependoparvovirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageID "38798999".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageLength "11077".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageOutDegree "41".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageRevisionID "664542226".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Adeno-associated_virus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Adenoviridae.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Adenovirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Base_pair.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Carcinogen.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Category:Genetic_engineering.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Category:Parvovirinae.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Clinical_research.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Clinical_trial.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Clinical_trials.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Coding_region.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink DNA.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink DNA_replication.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink DNA_synthesis.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Dependoparvovirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Dependovirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Exogeny.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Gene_expression.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Gene_therapy.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Genome.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Helper_virus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Herpesviridae.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Herpesvirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Immune_system.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink In_vitro.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink In_vivo.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Infection.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Nonenveloped.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Open_reading_frame.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Parvoviridae.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Parvovirinae.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Parvovirus.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Plasmid.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Primer_(molecular_biology).
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Rate-determining_step.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Recombinant_DNA.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Serotype.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Transcription_(genetics).
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Transduction_(genetics).
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Transgene.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink UV.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Ultraviolet.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Viral_envelope.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Viral_vector.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLink Virus_latency.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLinkText "Self-complementary adeno-associated virus (scAAV)".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLinkText "scAAV".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageWikiLinkText "self-complementary adeno-associated virus (scAAV)".
- Self-complementary_adeno-associated_virus_(scAAV) color "violet".
- Self-complementary_adeno-associated_virus_(scAAV) familia "Parvoviridae".
- Self-complementary_adeno-associated_virus_(scAAV) genus "Dependovirus".
- Self-complementary_adeno-associated_virus_(scAAV) hasPhotoCollection Self-complementary_adeno-associated_virus_(scAAV).
- Self-complementary_adeno-associated_virus_(scAAV) name "adeno-associated virus".
- Self-complementary_adeno-associated_virus_(scAAV) name "self-complementary".
- Self-complementary_adeno-associated_virus_(scAAV) species "self-complementary adeno-associated virus".
- Self-complementary_adeno-associated_virus_(scAAV) subfamilia "Parvovirinae".
- Self-complementary_adeno-associated_virus_(scAAV) virusGroup "II".
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageUsesTemplate Template:Reflist.
- Self-complementary_adeno-associated_virus_(scAAV) wikiPageUsesTemplate Template:Taxobox.
- Self-complementary_adeno-associated_virus_(scAAV) subject Category:Genetic_engineering.
- Self-complementary_adeno-associated_virus_(scAAV) subject Category:Parvovirinae.
- Self-complementary_adeno-associated_virus_(scAAV) hypernym Vector.
- Self-complementary_adeno-associated_virus_(scAAV) type Insect.
- Self-complementary_adeno-associated_virus_(scAAV) type Species.
- Self-complementary_adeno-associated_virus_(scAAV) type Thing.
- Self-complementary_adeno-associated_virus_(scAAV) comment "Self-complementary adeno-associated virus (scAAV) is a viral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. Use of recombinant AAV (rAAV) has been successful in clinical trials addressing a variety of diseases. This lab-made progeny of rAAV is termed "self-complementary" because the coding region has been designed to form an intra-molecular double-stranded DNA template.".
- Self-complementary_adeno-associated_virus_(scAAV) label "Self-complementary adeno-associated virus (scAAV)".
- Self-complementary_adeno-associated_virus_(scAAV) sameAs m.0rpgzq0.
- Self-complementary_adeno-associated_virus_(scAAV) sameAs Q7447959.
- Self-complementary_adeno-associated_virus_(scAAV) sameAs Q7447959.
- Self-complementary_adeno-associated_virus_(scAAV) wasDerivedFrom Self-complementary_adeno-associated_virus_(scAAV)?oldid=664542226.
- Self-complementary_adeno-associated_virus_(scAAV) isPrimaryTopicOf Self-complementary_adeno-associated_virus_(scAAV).
- Self-complementary_adeno-associated_virus_(scAAV) name "adeno-associated virus".
- Self-complementary_adeno-associated_virus_(scAAV) name "self-complementary".