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- SecY_protein abstract "The SecY protein is the main transmembrane subunit of the eubacterial Sec or Type II secretory pathway and a protein-secreting ATPase complex, also known as a translocon. Secretion of some proteins carrying a signal-peptide across the inner membrane in Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component within the membrane. From there, the mature proteins are either targeted to the outer membrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterial chromosome.The translocase pathway comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF). The chaperone protein SecB is a highly acidic homotetrameric protein that exists as a "dimer of dimers" in the bacterial cytoplasm. SecB maintains preproteins in an unfolded state after translation, and targets these to the peripheral membrane protein ATPase SecA for secretion. The structure of the Escherichia coli SecYEG assembly revealed a sandwich of two membranes interacting through the extensive cytoplasmic domains. Each membrane is composed of dimers of SecYEG. The monomeric complex contains 15 transmembrane helices.The eubacterial secY protein interacts with the signal sequences of secretory proteins as well as with two other components ofthe protein translocation system: secA and secE. SecY is an integral plasma membrane protein of 419 to 492 amino acid residues that apparently contains 10 transmembrane (TM), 6 cytoplasmic and 5 periplasmic regions.Cytoplasmic regions 2 and 3, and TM domains 1, 2, 4, 5, 7 and 10 are well conserved: the conserved cytoplasmic regions are believed to interact with cytoplasmic secretion factors, while the TM domains may participate in protein export. Homologs of secY are found in archaebacteria. SecY is also encoded in the chloroplast genome of some algae where it could be involved in a prokaryotic-like protein export system across the two membranes of the chloroplast endoplasmic reticulum (CER) which is present in chromophyte and cryptophyte algae.".
- SecY_protein symbol "SecY".
- SecY_protein thumbnail PDB_1rh5_EBI.jpg?width=300.
- SecY_protein wikiPageID "14668187".
- SecY_protein wikiPageLength "5649".
- SecY_protein wikiPageOutDegree "18".
- SecY_protein wikiPageRevisionID "679044468".
- SecY_protein wikiPageWikiLink Category:Protein_domains.
- SecY_protein wikiPageWikiLink Category:Protein_families.
- SecY_protein wikiPageWikiLink Category:Protein_targeting.
- SecY_protein wikiPageWikiLink Category:Secretion.
- SecY_protein wikiPageWikiLink Category:Transmembrane_proteins.
- SecY_protein wikiPageWikiLink Chaperone_(protein).
- SecY_protein wikiPageWikiLink Chaperone_protein.
- SecY_protein wikiPageWikiLink Gram-negative_bacteria.
- SecY_protein wikiPageWikiLink Inner_membrane.
- SecY_protein wikiPageWikiLink Protein-secreting_ATPase.
- SecY_protein wikiPageWikiLink SEC61A1.
- SecY_protein wikiPageWikiLink SEC61A2.
- SecY_protein wikiPageWikiLink Sec61_alpha_1.
- SecY_protein wikiPageWikiLink SecA.
- SecY_protein wikiPageWikiLink SecB.
- SecY_protein wikiPageWikiLink SecY-related_translocase.
- SecY_protein wikiPageWikiLink Secretory_pathway.
- SecY_protein wikiPageWikiLink Signal_peptide.
- SecY_protein wikiPageWikiLink Translocon.
- SecY_protein wikiPageWikiLink Transmembrane.
- SecY_protein wikiPageWikiLink Transmembrane_protein.
- SecY_protein wikiPageWikiLinkText "SecY protein".
- SecY_protein wikiPageWikiLinkText "SecY".
- SecY_protein caption "Structure of a protein-conducting channel.".
- SecY_protein hasPhotoCollection SecY_protein.
- SecY_protein interpro "IPR002208".
- SecY_protein name "eubacterial secY protein".
- SecY_protein opmFamily "19".
- SecY_protein opmProtein "1".
- SecY_protein pdb "A:69-417 A:69-417".
- SecY_protein pfam "PF00344".
- SecY_protein prosite "PDOC00612".
- SecY_protein scop "1".
- SecY_protein symbol "SecY".
- SecY_protein tcdb "3".
- SecY_protein wikiPageUsesTemplate Template:InterPro.
- SecY_protein wikiPageUsesTemplate Template:Pfam_box.
- SecY_protein wikiPageUsesTemplate Template:Reflist.
- SecY_protein subject Category:Protein_domains.
- SecY_protein subject Category:Protein_families.
- SecY_protein subject Category:Protein_targeting.
- SecY_protein subject Category:Secretion.
- SecY_protein subject Category:Transmembrane_proteins.
- SecY_protein hypernym Subunit.
- SecY_protein type Biomolecule.
- SecY_protein type Protein.
- SecY_protein type Chemical.
- SecY_protein type Domain.
- SecY_protein type Thing.
- SecY_protein type Q206229.
- SecY_protein type Q8054.
- SecY_protein comment "The SecY protein is the main transmembrane subunit of the eubacterial Sec or Type II secretory pathway and a protein-secreting ATPase complex, also known as a translocon. Secretion of some proteins carrying a signal-peptide across the inner membrane in Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component within the membrane.".
- SecY_protein label "SecY protein".
- SecY_protein sameAs m.03gsf_y.
- SecY_protein sameAs Q7442852.
- SecY_protein sameAs Q7442852.
- SecY_protein wasDerivedFrom SecY_protein?oldid=679044468.
- SecY_protein depiction PDB_1rh5_EBI.jpg.
- SecY_protein isPrimaryTopicOf SecY_protein.