Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/STIM2> ?p ?o }
- STIM2 abstract "Stromal interaction molecule 2 (STIM2) is a protein that in humans is encoded by the STIM2 gene.This gene is a member of the stromal interaction molecule (STIM) family which comprises only two members together with its homologue STIM1, and likely arose from a common ancestral gene. They encode type 1 transmembrane proteins that are located in the sarco/endoplasmic reticulum (SR / ER) into the cell. Alternative translation initiation from an AUG and a non-AUG (UUG) start site results in the production of two different STIM2 isoforms.Both members of the STIM family were identified in 2005 as free-calcium (Ca2+) sensors which participate in a mechanism of Ca2+ entry into the cell referred to as store-operated Ca2+ entry (SOCE). Many cellular processes and signaling pathways are started by previous release of Ca2+ stored in subcellular organelles, which needs of a continuous refilling. SOCE is considered the mechanism of store refilling and an essential mechanism of Ca2+ signaling in non-electrically excitable cells. While STIM1 triggers SOCE, research on STIM2 function suggests a major role as feedback regulator that stabilizes basal cytosolic and S/ER Ca2+ concentration [Ca2+]. STIM2 detects small decreases in Ca2+ content stored in the S/ER, switches to the activated state and interacts with so called store-operated Ca2+ (SOC) channels located in the plasma membrane, such as Orai or TRPC channels, allowing SOCE. Although the functional role of STIM2 has been elusive for many years, studies performed in 2009-2010 on murine models suggested that STIM2 participates in processes of the development and functioning of many cell types, including smooth muscle myoblasts, cells of the immune system and neurons, and is involved in tumorigenesis, the development of autoimmune diseases and mechanisms of neuronal damage after transient ischemic conditions.".
- STIM2 entrezgene "57620".
- STIM2 wikiPageID "15224791".
- STIM2 wikiPageLength "32955".
- STIM2 wikiPageOutDegree "103".
- STIM2 wikiPageRevisionID "619646824".
- STIM2 wikiPageWikiLink Alpha_helix.
- STIM2 wikiPageWikiLink Amino_acid.
- STIM2 wikiPageWikiLink Autoimmune_disease.
- STIM2 wikiPageWikiLink BLAST.
- STIM2 wikiPageWikiLink Brain_ischemia.
- STIM2 wikiPageWikiLink C-terminus.
- STIM2 wikiPageWikiLink Calcium_in_biology.
- STIM2 wikiPageWikiLink Calcium_release_activated_channel.
- STIM2 wikiPageWikiLink Calmodulin.
- STIM2 wikiPageWikiLink Carcinogenesis.
- STIM2 wikiPageWikiLink Cell_culture.
- STIM2 wikiPageWikiLink Cell_membrane.
- STIM2 wikiPageWikiLink Cell_nucleus.
- STIM2 wikiPageWikiLink Centromere.
- STIM2 wikiPageWikiLink Choanoflagellate.
- STIM2 wikiPageWikiLink Coiled_coil.
- STIM2 wikiPageWikiLink Cytosol.
- STIM2 wikiPageWikiLink Drosophila_melanogaster.
- STIM2 wikiPageWikiLink EF_hand.
- STIM2 wikiPageWikiLink ERM_protein_family.
- STIM2 wikiPageWikiLink Endoplasmic_reticulum.
- STIM2 wikiPageWikiLink Eukaryote.
- STIM2 wikiPageWikiLink Eukaryotes.
- STIM2 wikiPageWikiLink Exon.
- STIM2 wikiPageWikiLink Gene.
- STIM2 wikiPageWikiLink Gene_knockdown.
- STIM2 wikiPageWikiLink Glioblastoma_multiforme.
- STIM2 wikiPageWikiLink Glycosylation.
- STIM2 wikiPageWikiLink HEK_293_cells.
- STIM2 wikiPageWikiLink HEK_cell.
- STIM2 wikiPageWikiLink Hippocampus.
- STIM2 wikiPageWikiLink Histidine.
- STIM2 wikiPageWikiLink Homeostasis.
- STIM2 wikiPageWikiLink Immune_system.
- STIM2 wikiPageWikiLink Immunoprecipitation.
- STIM2 wikiPageWikiLink Inositol_trisphosphate_receptor.
- STIM2 wikiPageWikiLink Interferon-gamma.
- STIM2 wikiPageWikiLink Interferon_gamma.
- STIM2 wikiPageWikiLink Interleukin_2.
- STIM2 wikiPageWikiLink Intron.
- STIM2 wikiPageWikiLink Ischemia.
- STIM2 wikiPageWikiLink Knockout_mouse.
- STIM2 wikiPageWikiLink Lumen_(anatomy).
- STIM2 wikiPageWikiLink Lysine.
- STIM2 wikiPageWikiLink MRNA.
- STIM2 wikiPageWikiLink Messenger_RNA.
- STIM2 wikiPageWikiLink Monosiga.
- STIM2 wikiPageWikiLink Myoblasts.
- STIM2 wikiPageWikiLink Myocyte.
- STIM2 wikiPageWikiLink Myogenesis.
- STIM2 wikiPageWikiLink N-terminus.
- STIM2 wikiPageWikiLink NFAT.
- STIM2 wikiPageWikiLink Neurodegeneration.
- STIM2 wikiPageWikiLink Neuron.
- STIM2 wikiPageWikiLink Neurons.
- STIM2 wikiPageWikiLink Neuroprotection.
- STIM2 wikiPageWikiLink ORAI1.
- STIM2 wikiPageWikiLink Organelle.
- STIM2 wikiPageWikiLink Organelles.
- STIM2 wikiPageWikiLink Peptide.
- STIM2 wikiPageWikiLink Peptides.
- STIM2 wikiPageWikiLink Phosphatidylinositol.
- STIM2 wikiPageWikiLink Phosphorylation.
- STIM2 wikiPageWikiLink Plasma_membrane.
- STIM2 wikiPageWikiLink Prokaryote.
- STIM2 wikiPageWikiLink Proline.
- STIM2 wikiPageWikiLink Protein.
- STIM2 wikiPageWikiLink Protein_domain.
- STIM2 wikiPageWikiLink Protein_isoform.
- STIM2 wikiPageWikiLink SERCA.
- STIM2 wikiPageWikiLink SOC_channels.
- STIM2 wikiPageWikiLink STIM1.
- STIM2 wikiPageWikiLink Serine.
- STIM2 wikiPageWikiLink Small_interfering_RNA.
- STIM2 wikiPageWikiLink Spatial_memory.
- STIM2 wikiPageWikiLink Store-Operated_Calcium_channel.
- STIM2 wikiPageWikiLink Submandibular_gland.
- STIM2 wikiPageWikiLink Synapse.
- STIM2 wikiPageWikiLink TRPC.
- STIM2 wikiPageWikiLink T_cell.
- STIM2 wikiPageWikiLink T_cells.
- STIM2 wikiPageWikiLink T_helper_17_cell.
- STIM2 wikiPageWikiLink T_helper_cell.
- STIM2 wikiPageWikiLink Thapsigargin.
- STIM2 wikiPageWikiLink Transmembrane_domain.
- STIM2 wikiPageWikiLink Transmembrane_protein.
- STIM2 wikiPageWikiLink File:Stim_familly_wiki.jpg.
- STIM2 wikiPageWikiLinkText "STIM2".
- STIM2 hasPhotoCollection STIM2.
- STIM2 wikiPageUsesTemplate Template:PBB.
- STIM2 wikiPageUsesTemplate Template:Reflist.
- STIM2 hypernym Protein.
- STIM2 type Biomolecule.
- STIM2 type Protein.