Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/STIL> ?p ?o }
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- STIL abstract "SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.Homozygous mutations in the STIL gene cause primary microcephaly (small brain) in humans.".
- STIL entrezgene "6491".
- STIL wikiPageID "14769408".
- STIL wikiPageLength "8079".
- STIL wikiPageOutDegree "2".
- STIL wikiPageRevisionID "679041832".
- STIL wikiPageWikiLink Gene.
- STIL wikiPageWikiLink Protein.
- STIL wikiPageWikiLinkText "STIL".
- STIL hasPhotoCollection STIL.
- STIL requireManualInspection "no".
- STIL summaryText "This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V--J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.".
- STIL updateCitations "yes".
- STIL updatePage "yes".
- STIL updateProteinBox "yes".
- STIL updateSummary "yes".
- STIL wikiPageUsesTemplate Template:Gene-1-stub.
- STIL wikiPageUsesTemplate Template:PBB.
- STIL wikiPageUsesTemplate Template:PBB_Controls.
- STIL wikiPageUsesTemplate Template:PBB_Further_reading.
- STIL wikiPageUsesTemplate Template:PBB_Summary.
- STIL wikiPageUsesTemplate Template:Refbegin.
- STIL wikiPageUsesTemplate Template:Refend.
- STIL wikiPageUsesTemplate Template:Reflist.
- STIL wikiPageUsesTemplate Template:Underlinked.
- STIL hypernym Protein.
- STIL type Article.
- STIL type Biomolecule.
- STIL type Protein.
- STIL type Article.
- STIL type Thing.
- STIL type Q206229.
- STIL type Q8054.
- STIL comment "SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase.".
- STIL label "STIL".
- STIL sameAs m.03gxcfn.
- STIL sameAs Q7394741.
- STIL sameAs Q7394741.
- STIL wasDerivedFrom STIL?oldid=679041832.
- STIL isPrimaryTopicOf STIL.