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- SOX_gene_family abstract "SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species. Sox genes are defined as containing the HMG box of a gene involved in sex determination called SRY, which resides on the Y-chromosome (Sox stands for Sry-related HMG box). There are 20 SOX genes present in humans and mice, and 8 present in Drosophila. Almost all Sox genes show at least 50% amino acid similarity with the HMG box in Sry. The family is divided into subgroups according to homology within the HMG domain and other structural motifs, as well as according to functional assays.The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. While many Sox genes are involved in sex determination, some are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition of epithelial granule cells in the cerebellum to their migratory state. Granule cells then differentiate to granule neurons, with Sox11 being involved in this process. It is thought that some Sox genes may be useful in the early diagnosis of childhood brain tumours due to this sequential expression in the cerebellum, making them a target for significant research.Sox proteins bind to the sequence WWCAAW and similar sequences (W=A/T). They have weak binding specificity and unusually low affinity for DNA. Sox genes are related to the Tcf/Lef1 group of genes which also contain a sequence-specific high mobility group and have a similar sequence specificity (roughly TWWCAAAG).".
- SOX_gene_family wikiPageID "3908779".
- SOX_gene_family wikiPageLength "4965".
- SOX_gene_family wikiPageOutDegree "44".
- SOX_gene_family wikiPageRevisionID "671844419".
- SOX_gene_family wikiPageWikiLink Amino_acid.
- SOX_gene_family wikiPageWikiLink Amino_acids.
- SOX_gene_family wikiPageWikiLink Body_plan.
- SOX_gene_family wikiPageWikiLink Brain_tumor.
- SOX_gene_family wikiPageWikiLink Brain_tumour.
- SOX_gene_family wikiPageWikiLink Category:Gene_families.
- SOX_gene_family wikiPageWikiLink Category:Transcription_factors.
- SOX_gene_family wikiPageWikiLink DNA.
- SOX_gene_family wikiPageWikiLink DNA-binding_domain.
- SOX_gene_family wikiPageWikiLink DNA_binding_domain.
- SOX_gene_family wikiPageWikiLink DNA_sequence.
- SOX_gene_family wikiPageWikiLink Eukaryote.
- SOX_gene_family wikiPageWikiLink Evolutionary_developmental_biology.
- SOX_gene_family wikiPageWikiLink Gene.
- SOX_gene_family wikiPageWikiLink Genes.
- SOX_gene_family wikiPageWikiLink HMG-box.
- SOX_gene_family wikiPageWikiLink High-mobility_group.
- SOX_gene_family wikiPageWikiLink High_mobility_group.
- SOX_gene_family wikiPageWikiLink Homeobox.
- SOX_gene_family wikiPageWikiLink Homology_(biology).
- SOX_gene_family wikiPageWikiLink Minor_groove.
- SOX_gene_family wikiPageWikiLink Neuron.
- SOX_gene_family wikiPageWikiLink Neuronal.
- SOX_gene_family wikiPageWikiLink Nucleic_Acids_Research.
- SOX_gene_family wikiPageWikiLink Nucleic_acid_double_helix.
- SOX_gene_family wikiPageWikiLink Nucleic_acid_sequence.
- SOX_gene_family wikiPageWikiLink Pax_genes.
- SOX_gene_family wikiPageWikiLink SOX1.
- SOX_gene_family wikiPageWikiLink SOX10.
- SOX_gene_family wikiPageWikiLink SOX11.
- SOX_gene_family wikiPageWikiLink SOX12.
- SOX_gene_family wikiPageWikiLink SOX13.
- SOX_gene_family wikiPageWikiLink SOX14.
- SOX_gene_family wikiPageWikiLink SOX15.
- SOX_gene_family wikiPageWikiLink SOX17.
- SOX_gene_family wikiPageWikiLink SOX18.
- SOX_gene_family wikiPageWikiLink SOX2.
- SOX_gene_family wikiPageWikiLink SOX21.
- SOX_gene_family wikiPageWikiLink SOX3.
- SOX_gene_family wikiPageWikiLink SOX30.
- SOX_gene_family wikiPageWikiLink SOX4.
- SOX_gene_family wikiPageWikiLink SOX5.
- SOX_gene_family wikiPageWikiLink SOX6.
- SOX_gene_family wikiPageWikiLink SOX7.
- SOX_gene_family wikiPageWikiLink SOX8.
- SOX_gene_family wikiPageWikiLink SOX9.
- SOX_gene_family wikiPageWikiLink SRY.
- SOX_gene_family wikiPageWikiLink LEF_family.
- SOX_gene_family wikiPageWikiLink Testis_determining_factor.
- SOX_gene_family wikiPageWikiLink Transcription_factor.
- SOX_gene_family wikiPageWikiLink Y-chromosome.
- SOX_gene_family wikiPageWikiLink Y_chromosome.
- SOX_gene_family wikiPageWikiLinkText "SOX gene family".
- SOX_gene_family wikiPageWikiLinkText "SOX".
- SOX_gene_family hasPhotoCollection SOX_gene_family.
- SOX_gene_family wikiPageUsesTemplate Template:Cite_journal.
- SOX_gene_family wikiPageUsesTemplate Template:Genetics-stub.
- SOX_gene_family wikiPageUsesTemplate Template:Reflist.
- SOX_gene_family wikiPageUsesTemplate Template:Transcription_factors.
- SOX_gene_family subject Category:Gene_families.
- SOX_gene_family subject Category:Transcription_factors.
- SOX_gene_family comment "SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals.".
- SOX_gene_family label "SOX gene family".
- SOX_gene_family sameAs پروتئینهای_خانواده_ساکس.
- SOX_gene_family sameAs Protéines_SOX.
- SOX_gene_family sameAs m.0b69d0.
- SOX_gene_family sameAs Q3408238.
- SOX_gene_family sameAs Q3408238.
- SOX_gene_family wasDerivedFrom SOX_gene_family?oldid=671844419.
- SOX_gene_family isPrimaryTopicOf SOX_gene_family.