Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/SDC4> ?p ?o }
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- SDC4 abstract "Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.Syndecans have similar structural features: Attach to heparan sulfate chains – interacting factors (e.g. Matrix molecules, growth factors, and enzymes)Chondroitin sulfate chainTransmembrane domain – self-associationC1 domain – actin-association cytoskeletonVariable domain – syndecan-specificC2 domain – attach to PDZ proteinsSyndecans normally form homodimers or multimers. Their biological function includes cell growth regulation, differentiation, and adhesion.Syndecan-4 has more widespread distribution than other syndecans and it is the only syndecan that has been found consistently in focal adhesions.".
- SDC4 entrezgene "6385".
- SDC4 wikiPageID "14145006".
- SDC4 wikiPageLength "15254".
- SDC4 wikiPageOutDegree "7".
- SDC4 wikiPageRevisionID "610198248".
- SDC4 wikiPageWikiLink Gene.
- SDC4 wikiPageWikiLink Heparan_sulfate.
- SDC4 wikiPageWikiLink Osteoarthritis.
- SDC4 wikiPageWikiLink Protein.
- SDC4 wikiPageWikiLink Proteoglycan.
- SDC4 wikiPageWikiLink Pseudogene.
- SDC4 wikiPageWikiLink Syndecan.
- SDC4 wikiPageWikiLinkText "-4".
- SDC4 wikiPageWikiLinkText "SDC4".
- SDC4 wikiPageWikiLinkText "syndecan-4".
- SDC4 hasPhotoCollection SDC4.
- SDC4 wikiPageUsesTemplate Template:Cite_journal.
- SDC4 wikiPageUsesTemplate Template:PBB.
- SDC4 wikiPageUsesTemplate Template:PDB_Gallery.
- SDC4 wikiPageUsesTemplate Template:Refbegin.
- SDC4 wikiPageUsesTemplate Template:Refend.
- SDC4 wikiPageUsesTemplate Template:Reflist.
- SDC4 hypernym Protein.
- SDC4 type Biomolecule.
- SDC4 type Protein.
- SDC4 type Thing.
- SDC4 type Q206229.
- SDC4 type Q8054.
- SDC4 comment "Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells.".
- SDC4 label "SDC4".
- SDC4 sameAs Sindecán-4.
- SDC4 sameAs m.03cv_8r.
- SDC4 sameAs Синдекан_4.
- SDC4 sameAs Q4420086.
- SDC4 sameAs Q4420086.
- SDC4 wasDerivedFrom SDC4?oldid=610198248.
- SDC4 isPrimaryTopicOf SDC4.