Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/S-14671> ?p ?o }
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- S-14671 abstract "S-14671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8). It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.In producing 5-HT1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14671 is active at doses as low as 5 µg subcutaneously, and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone. Other 5-HT1A-mediated effects of S-14671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.S-14671 has been found to possess powerful efficacy in the rodent forced swim test and in the pigeon conflict test, indicating marked antidepressant and anxiolytic effects, respectively, of which are also 5-HT1A-mediated. It has never been trialed in humans, perhaps due to its potency being too great.".
- S-14671 atcPrefix "none".
- S-14671 casNumber "135722-27-9".
- S-14671 iupacName "N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}thiophene-2-carboxamide".
- S-14671 pubchem "131907".
- S-14671 thumbnail S-14671-structure.png?width=300.
- S-14671 wikiPageID "28482815".
- S-14671 wikiPageLength "4586".
- S-14671 wikiPageOutDegree "40".
- S-14671 wikiPageRevisionID "679037576".
- S-14671 wikiPageWikiLink 5-HT1A_receptor.
- S-14671 wikiPageWikiLink 5-HT1B_receptor.
- S-14671 wikiPageWikiLink 5-HT2A_receptor.
- S-14671 wikiPageWikiLink 5-HT2C_receptor.
- S-14671 wikiPageWikiLink 5-HT3_receptor.
- S-14671 wikiPageWikiLink 8-OH-DPAT.
- S-14671 wikiPageWikiLink Activity_(chemistry).
- S-14671 wikiPageWikiLink Affinity_(pharmacology).
- S-14671 wikiPageWikiLink Agonist.
- S-14671 wikiPageWikiLink Analgesic.
- S-14671 wikiPageWikiLink Antidepressant.
- S-14671 wikiPageWikiLink Antinociception.
- S-14671 wikiPageWikiLink Anxiolytic.
- S-14671 wikiPageWikiLink Behavioural_despair_test.
- S-14671 wikiPageWikiLink Binding_site.
- S-14671 wikiPageWikiLink Buspirone.
- S-14671 wikiPageWikiLink CSP-2503.
- S-14671 wikiPageWikiLink Category:Carboxamides.
- S-14671 wikiPageWikiLink Category:Naphthol_ethers.
- S-14671 wikiPageWikiLink Category:Phenol_ethers.
- S-14671 wikiPageWikiLink Category:Piperazines.
- S-14671 wikiPageWikiLink Category:Thiophenes.
- S-14671 wikiPageWikiLink Chemical_derivative.
- S-14671 wikiPageWikiLink Clinical_trial.
- S-14671 wikiPageWikiLink Conflict_test.
- S-14671 wikiPageWikiLink Corticosterone.
- S-14671 wikiPageWikiLink Derivative_(chemistry).
- S-14671 wikiPageWikiLink Dorsal_raphe_nucleus.
- S-14671 wikiPageWikiLink Dose_(biochemistry).
- S-14671 wikiPageWikiLink Efficacy.
- S-14671 wikiPageWikiLink Electrical_activity.
- S-14671 wikiPageWikiLink Electrical_phenomena.
- S-14671 wikiPageWikiLink Flesinoxan.
- S-14671 wikiPageWikiLink Forced_swim_test.
- S-14671 wikiPageWikiLink Hypothermia.
- S-14671 wikiPageWikiLink In_vivo.
- S-14671 wikiPageWikiLink Ligand_(biochemistry).
- S-14671 wikiPageWikiLink Morphine.
- S-14671 wikiPageWikiLink Naphthylpiperazine.
- S-14671 wikiPageWikiLink Potency_(pharmacology).
- S-14671 wikiPageWikiLink Receptor_antagonist.
- S-14671 wikiPageWikiLink Secretion.
- S-14671 wikiPageWikiLink Subcutaneous_injection.
- S-14671 wikiPageWikiLink Thermodynamic_activity.
- S-14671 wikiPageWikiLinkText "S-14671".
- S-14671 alt "Skeletal formula of S-14671".
- S-14671 alt "Space-filling model of the S-14671 molecule".
- S-14671 atcPrefix "none".
- S-14671 c "22".
- S-14671 casNumber "135722".
- S-14671 chemspiderid "116529".
- S-14671 h "25".
- S-14671 hasPhotoCollection S-14671.
- S-14671 image "S-14,671-3D-spacefill.png".
- S-14671 iupacName "N-{2-[4-piperazin-1-yl]ethyl}thiophene-2-carboxamide".
- S-14671 iupharLigand "25".
- S-14671 molecularWeight "395.52".
- S-14671 n "3".
- S-14671 o "2".
- S-14671 pubchem "131907".
- S-14671 s "1".
- S-14671 width "230".
- S-14671 wikiPageUsesTemplate Template:Citation_needed.
- S-14671 wikiPageUsesTemplate Template:Drugbox.
- S-14671 wikiPageUsesTemplate Template:Piperazines.
- S-14671 wikiPageUsesTemplate Template:Reflist.
- S-14671 wikiPageUsesTemplate Template:Serotonergics.
- S-14671 wikiPageUsesTemplate Template:Technical.
- S-14671 subject Category:Carboxamides.
- S-14671 subject Category:Naphthol_ethers.
- S-14671 subject Category:Phenol_ethers.
- S-14671 subject Category:Piperazines.
- S-14671 subject Category:Thiophenes.
- S-14671 type ChemicalSubstance.
- S-14671 type Drug.
- S-14671 type ChemicalObject.
- S-14671 type Thing.
- S-14671 type Q8386.
- S-14671 comment "S-14671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).".
- S-14671 label "S-14671".
- S-14671 sameAs m.0crhbd2.
- S-14671 sameAs S-14,671.
- S-14671 sameAs S-14,671.
- S-14671 sameAs Q7387033.
- S-14671 sameAs Q7387033.
- S-14671 wasDerivedFrom S-14671?oldid=679037576.
- S-14671 depiction S-14671-structure.png.
- S-14671 isPrimaryTopicOf S-14671.