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- RyhB_RNA abstract "RyhB RNA is a 90 nucleotide non-coding RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur (Ferric uptake regulator). This ncRNA gene was independently identified in two screens, named RyhB by Wasserman et al. and called SraI by Argaman et al. and was found to be expressed only in stationary phase. RyhB RNA levels are inversely correlated with mRNA levels for the sdhCDAB operon, encoding succinate dehydrogenase, as well as five other genes previously shown to be positively regulated by Fur by an unknown mechanism. These include two other genes encoding enzymes in the tricarboxylic acid cycle, acnA and fumA, two ferritin genes, ftnA and bfr, and a gene for superoxide dismutase, sodB. A number of other genes have been predicted computationally and verified as targets by microarray analysis: napF, sodA, cysE, yciS, acpS, nagZ and dadA. RyhB is bound by the Hfq protein, that increases its interaction with its target messages.A comparative genomics target prediction approach suggests that the mRNAs of eleven additional iron containing proteins are controlled by RyhB in Escherichia coli. Two of those (erpA, nirB) and two additional targets that are not directly related to iron (nagZ, marA) were verified with a GFP reporter system.It has been shown that RyhB has a role in targeting the polycistronic transcript iscRSUA for differential degradation. RyhB binds to the second cistron of iscRSUA, which encodes machinery for biosynthesis of Fe-S clusters. This binding promotes cleavage of the downstream iscSUA transcript. This cleavage leaves the 5' IscR transcript which is a transcriptional regulator responsible regulating several genes that depend on cellular Fe-S level.RyhB is an analog of the sRNA PrrF RNA found in Pseudomonas aeruginosa.".
- RyhB_RNA thumbnail RyhB_sodB.jpg?width=300.
- RyhB_RNA wikiPageExternalLink pmidlookup?view=long&pmid=16199566.
- RyhB_RNA wikiPageID "11421489".
- RyhB_RNA wikiPageLength "15271".
- RyhB_RNA wikiPageOutDegree "17".
- RyhB_RNA wikiPageRevisionID "678189813".
- RyhB_RNA wikiPageWikiLink Analogy_(biology).
- RyhB_RNA wikiPageWikiLink Category:Non-coding_RNA.
- RyhB_RNA wikiPageWikiLink Citric_acid_cycle.
- RyhB_RNA wikiPageWikiLink Convergent_evolution.
- RyhB_RNA wikiPageWikiLink Escherichia_coli.
- RyhB_RNA wikiPageWikiLink Ferritin.
- RyhB_RNA wikiPageWikiLink Hfq_protein.
- RyhB_RNA wikiPageWikiLink Microarray.
- RyhB_RNA wikiPageWikiLink Non-coding_RNA.
- RyhB_RNA wikiPageWikiLink Nucleotide.
- RyhB_RNA wikiPageWikiLink Protein.
- RyhB_RNA wikiPageWikiLink PrrF_RNA.
- RyhB_RNA wikiPageWikiLink RydB_RNA.
- RyhB_RNA wikiPageWikiLink RyeB_RNA.
- RyhB_RNA wikiPageWikiLink RyeE_RNA.
- RyhB_RNA wikiPageWikiLink RyfA_RNA.
- RyhB_RNA wikiPageWikiLink Superoxide_dismutase.
- RyhB_RNA wikiPageWikiLink File:RyhB_sodB.jpg.
- RyhB_RNA wikiPageWikiLinkText "RyhB RNA".
- RyhB_RNA wikiPageWikiLinkText "RyhB".
- RyhB_RNA hasPhotoCollection RyhB_RNA.
- RyhB_RNA id "RF00057".
- RyhB_RNA name "RyhB RNA".
- RyhB_RNA wikiPageUsesTemplate Template:Cite_journal.
- RyhB_RNA wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- RyhB_RNA wikiPageUsesTemplate Template:Refbegin.
- RyhB_RNA wikiPageUsesTemplate Template:Refend.
- RyhB_RNA wikiPageUsesTemplate Template:Reflist.
- RyhB_RNA wikiPageUsesTemplate Template:Rfam.
- RyhB_RNA subject Category:Non-coding_RNA.
- RyhB_RNA comment "RyhB RNA is a 90 nucleotide non-coding RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur (Ferric uptake regulator). This ncRNA gene was independently identified in two screens, named RyhB by Wasserman et al. and called SraI by Argaman et al. and was found to be expressed only in stationary phase.".
- RyhB_RNA label "RyhB RNA".
- RyhB_RNA sameAs m.02rb_dd.
- RyhB_RNA sameAs Q7385058.
- RyhB_RNA sameAs Q7385058.
- RyhB_RNA wasDerivedFrom RyhB_RNA?oldid=678189813.
- RyhB_RNA depiction RyhB_sodB.jpg.
- RyhB_RNA isPrimaryTopicOf RyhB_RNA.