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- Roxindole abstract "Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia. In clinical trials its antipsychotic efficacy was only modest but it was unexpectedly found to produce potent and rapid antidepressant and anxiolytic effects. As a result, roxindole was further researched for the treatment of depression instead. It has also been investigated as a therapy for Parkinson's disease and prolactinoma.Roxindole acts as an agonist at the following receptors: D2 receptor (pKi = 8.55) D3 receptor (pKi = 8.93) D4 receptor (pKi = 8.23) 5-HT1A receptor (pKi = 9.42)At D2 and possibly D3 receptors roxindole is a partial agonist with preferential actions at autoreceptors and has been touted as a 'selective' autoreceptor agonist, hence the justification of its application as an antipsychotic. Weaker activity at the serotonin 1B and 1D receptors has been seen. It is also a serotonin reuptake inhibitor (IC50 = 1.4 nM) and has been reported to act as a 5-HT2A receptor antagonist as well.".
- Roxindole atcPrefix "none".
- Roxindole casNumber "112192-04-8".
- Roxindole fdaUniiCode "43227SMS0O".
- Roxindole iupacName "3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol".
- Roxindole pubchem "219050".
- Roxindole thumbnail Roxindole.png?width=300.
- Roxindole wikiPageID "26523915".
- Roxindole wikiPageLength "10024".
- Roxindole wikiPageOutDegree "26".
- Roxindole wikiPageRevisionID "665797182".
- Roxindole wikiPageWikiLink 5-HT1A_receptor.
- Roxindole wikiPageWikiLink 5-HT2A_receptor.
- Roxindole wikiPageWikiLink Agonist.
- Roxindole wikiPageWikiLink Antidepressant.
- Roxindole wikiPageWikiLink Antipsychotic.
- Roxindole wikiPageWikiLink Anxiolytic.
- Roxindole wikiPageWikiLink Autoreceptor.
- Roxindole wikiPageWikiLink Binding_selectivity.
- Roxindole wikiPageWikiLink Category:Indoles.
- Roxindole wikiPageWikiLink Category:Phenols.
- Roxindole wikiPageWikiLink Category:Pyridines.
- Roxindole wikiPageWikiLink Clinical_trial.
- Roxindole wikiPageWikiLink D2_receptor.
- Roxindole wikiPageWikiLink D3_receptor.
- Roxindole wikiPageWikiLink D4_receptor.
- Roxindole wikiPageWikiLink Dopamine_receptor_D2.
- Roxindole wikiPageWikiLink Dopamine_receptor_D3.
- Roxindole wikiPageWikiLink Dopamine_receptor_D4.
- Roxindole wikiPageWikiLink Dopaminergic.
- Roxindole wikiPageWikiLink Drug.
- Roxindole wikiPageWikiLink Major_depression.
- Roxindole wikiPageWikiLink Major_depressive_disorder.
- Roxindole wikiPageWikiLink Parkinsons_disease.
- Roxindole wikiPageWikiLink Partial_agonist.
- Roxindole wikiPageWikiLink Prolactinoma.
- Roxindole wikiPageWikiLink Receptor_(biochemistry).
- Roxindole wikiPageWikiLink Receptor_antagonist.
- Roxindole wikiPageWikiLink Schizophrenia.
- Roxindole wikiPageWikiLink Serotonergic.
- Roxindole wikiPageWikiLink Serotonin_reuptake_inhibitor.
- Roxindole wikiPageWikiLinkText "Roxindole".
- Roxindole atcPrefix "none".
- Roxindole c "23".
- Roxindole casNumber "112192".
- Roxindole chemspiderid "189880".
- Roxindole h "26".
- Roxindole hasPhotoCollection Roxindole.
- Roxindole iupacName "3".
- Roxindole iupharLigand "52".
- Roxindole molecularWeight "346.47".
- Roxindole n "2".
- Roxindole o "1".
- Roxindole pubchem "219050".
- Roxindole smiles "Oc1ccc2ccCCCCN4C/C=CCC4".
- Roxindole unii "43227".
- Roxindole wikiPageUsesTemplate Template:Antidepressants.
- Roxindole wikiPageUsesTemplate Template:Antiparkinson.
- Roxindole wikiPageUsesTemplate Template:Antipsychotics.
- Roxindole wikiPageUsesTemplate Template:Anxiolytics.
- Roxindole wikiPageUsesTemplate Template:Dopaminergics.
- Roxindole wikiPageUsesTemplate Template:Drugbox.
- Roxindole wikiPageUsesTemplate Template:Reflist.
- Roxindole wikiPageUsesTemplate Template:Serotonergics.
- Roxindole subject Category:Indoles.
- Roxindole subject Category:Phenols.
- Roxindole subject Category:Pyridines.
- Roxindole hypernym Drug.
- Roxindole type ChemicalSubstance.
- Roxindole type Drug.
- Roxindole type Alcohol.
- Roxindole type Drug.
- Roxindole type Heterocycle.
- Roxindole type ChemicalObject.
- Roxindole type Thing.
- Roxindole type Q8386.
- Roxindole comment "Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia. In clinical trials its antipsychotic efficacy was only modest but it was unexpectedly found to produce potent and rapid antidepressant and anxiolytic effects. As a result, roxindole was further researched for the treatment of depression instead.".
- Roxindole label "Roxindole".
- Roxindole sameAs m.0bh6z7m.
- Roxindole sameAs Roksindol.
- Roxindole sameAs Roksindol.
- Roxindole sameAs Q7372445.
- Roxindole sameAs Q7372445.
- Roxindole wasDerivedFrom Roxindole?oldid=665797182.
- Roxindole depiction Roxindole.png.
- Roxindole isPrimaryTopicOf Roxindole.