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- Ro64-6198 abstract "Ro64-6198 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over other opioid receptors. It produces anxiolytic effects in animal studies equivalent to those of benzodiazepine drugs, but has no anticonvulsant effects and does not produce any overt effects on behaviour. However it does impair short-term memory, and counteracts stress-induced anorexia. It also has antitussive effects, and reduces the rewarding and analgesic effects of morphine, although it did not prevent the development of dependence. It has been shown to reduce alcohol self-administration in animals and suppressed relapses in animal models of alcoholism, and ORL-1 agonists may have application in the treatment of alcoholism.Ro64-6198 was able to be recognised as a discriminative stimulus by rats distinct from other opioid receptor ligands, but was not able to produce the conditioned place preference thought to be indicative of addictive potential. Consequently while the role of ORL-1 receptors in the body is complex and remains poorly understood, Ro64-6198 has demonstrated multiple pharmacological actions and has been very useful in the study of the ORL-1 receptor system, especially in relation to anxiety and anorexia; however, due to poor oral bioavailability, Ro 64-6198 will most likely not be pursued clinically. Studies in primates showed it to have analgesic effects but without producing respiratory depression or reinforcing effects.".
- Ro64-6198 iupacName "8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one".
- Ro64-6198 pubchem "9844019".
- Ro64-6198 thumbnail Ro64-6198_structure.png?width=300.
- Ro64-6198 wikiPageID "20159014".
- Ro64-6198 wikiPageLength "8111".
- Ro64-6198 wikiPageOutDegree "14".
- Ro64-6198 wikiPageRevisionID "637059501".
- Ro64-6198 wikiPageWikiLink Analgesic.
- Ro64-6198 wikiPageWikiLink Anticonvulsant.
- Ro64-6198 wikiPageWikiLink Antitussive.
- Ro64-6198 wikiPageWikiLink Anxiolytic.
- Ro64-6198 wikiPageWikiLink Benzodiazepine.
- Ro64-6198 wikiPageWikiLink Category:Hoffmann-La_Roche.
- Ro64-6198 wikiPageWikiLink Category:Lactams.
- Ro64-6198 wikiPageWikiLink Category:Nitrogen_heterocycles.
- Ro64-6198 wikiPageWikiLink Category:Nociceptin_receptor_agonists.
- Ro64-6198 wikiPageWikiLink Category:Opioids.
- Ro64-6198 wikiPageWikiLink Conditioned_place_preference.
- Ro64-6198 wikiPageWikiLink Cough_medicine.
- Ro64-6198 wikiPageWikiLink Hypoventilation.
- Ro64-6198 wikiPageWikiLink Nociceptin_receptor.
- Ro64-6198 wikiPageWikiLink Respiratory_depression.
- Ro64-6198 wikiPageWikiLinkText "Ro64-6198".
- Ro64-6198 c "26".
- Ro64-6198 chemspiderid "8019734".
- Ro64-6198 h "31".
- Ro64-6198 hasPhotoCollection Ro64-6198.
- Ro64-6198 inchi "1".
- Ro64-6198 inchikey "JLFMYEAXZNPWBK-REWPJTCUBE".
- Ro64-6198 iupacName "8".
- Ro64-6198 iupharLigand "1684".
- Ro64-6198 molecularWeight "401.543".
- Ro64-6198 n "3".
- Ro64-6198 o "1".
- Ro64-6198 pubchem "9844019".
- Ro64-6198 smiles "C1C[C@H]2CC[C@@H]N4CCC5CNCN5C6=CC=CC=C6".
- Ro64-6198 stdinchi "1".
- Ro64-6198 stdinchikey "JLFMYEAXZNPWBK-REWPJTCUSA-N".
- Ro64-6198 synonyms "Ro64-6198".
- Ro64-6198 verifiedfields "changed".
- Ro64-6198 verifiedrevid "451981063".
- Ro64-6198 width "200".
- Ro64-6198 wikiPageUsesTemplate Template:Drugbox.
- Ro64-6198 wikiPageUsesTemplate Template:Opioidergics.
- Ro64-6198 wikiPageUsesTemplate Template:Reflist.
- Ro64-6198 subject Category:Hoffmann-La_Roche.
- Ro64-6198 subject Category:Lactams.
- Ro64-6198 subject Category:Nitrogen_heterocycles.
- Ro64-6198 subject Category:Nociceptin_receptor_agonists.
- Ro64-6198 subject Category:Opioids.
- Ro64-6198 hypernym Drug.
- Ro64-6198 type Article.
- Ro64-6198 type ChemicalSubstance.
- Ro64-6198 type Company.
- Ro64-6198 type Drug.
- Ro64-6198 type Alkaloid.
- Ro64-6198 type Amide.
- Ro64-6198 type Analgesic.
- Ro64-6198 type Article.
- Ro64-6198 type Chemical.
- Ro64-6198 type Company.
- Ro64-6198 type Drug.
- Ro64-6198 type Heterocycle.
- Ro64-6198 type Lactam.
- Ro64-6198 type Opioid.
- Ro64-6198 type ChemicalObject.
- Ro64-6198 type Thing.
- Ro64-6198 type Q8386.
- Ro64-6198 comment "Ro64-6198 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over other opioid receptors. It produces anxiolytic effects in animal studies equivalent to those of benzodiazepine drugs, but has no anticonvulsant effects and does not produce any overt effects on behaviour.".
- Ro64-6198 label "Ro64-6198".
- Ro64-6198 sameAs m.04y67kd.
- Ro64-6198 sameAs Ro64-6198.
- Ro64-6198 sameAs Ro64-6198.
- Ro64-6198 sameAs Q7339209.
- Ro64-6198 sameAs Q7339209.
- Ro64-6198 wasDerivedFrom Ro64-6198?oldid=637059501.
- Ro64-6198 depiction Ro64-6198_structure.png.
- Ro64-6198 isPrimaryTopicOf Ro64-6198.