Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Ro5-4864> ?p ?o }
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- Ro5-4864 abstract "Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative, the 4'-chloro derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity. In vitro studies and rodent models also suggest the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer effects.".
- Ro5-4864 atcPrefix "none".
- Ro5-4864 casNumber "14439-61-3".
- Ro5-4864 iupacName "7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one".
- Ro5-4864 pubchem "1688".
- Ro5-4864 thumbnail Ro5-4864.svg?width=300.
- Ro5-4864 wikiPageID "29148689".
- Ro5-4864 wikiPageLength "9170".
- Ro5-4864 wikiPageOutDegree "20".
- Ro5-4864 wikiPageRevisionID "673940368".
- Ro5-4864 wikiPageWikiLink Analgesic.
- Ro5-4864 wikiPageWikiLink Antidepressant.
- Ro5-4864 wikiPageWikiLink Anxiogenic.
- Ro5-4864 wikiPageWikiLink Benzodiazepine.
- Ro5-4864 wikiPageWikiLink Category:Benzodiazepines.
- Ro5-4864 wikiPageWikiLink Category:Chloroarenes.
- Ro5-4864 wikiPageWikiLink Category:Hoffmann-La_Roche.
- Ro5-4864 wikiPageWikiLink Category:Lactams.
- Ro5-4864 wikiPageWikiLink Category:TSPO_ligands.
- Ro5-4864 wikiPageWikiLink Convulsant.
- Ro5-4864 wikiPageWikiLink Diazepam.
- Ro5-4864 wikiPageWikiLink Diclazepam.
- Ro5-4864 wikiPageWikiLink GABAA_receptor.
- Ro5-4864 wikiPageWikiLink In_vitro.
- Ro5-4864 wikiPageWikiLink Model_organism.
- Ro5-4864 wikiPageWikiLink Neuroprotection.
- Ro5-4864 wikiPageWikiLink Neuroprotective.
- Ro5-4864 wikiPageWikiLink PK-11195.
- Ro5-4864 wikiPageWikiLink Receptor_(biochemistry).
- Ro5-4864 wikiPageWikiLink Rodent_model.
- Ro5-4864 wikiPageWikiLink Sedative.
- Ro5-4864 wikiPageWikiLink TSPO_(protein).
- Ro5-4864 wikiPageWikiLink Translocator_protein.
- Ro5-4864 wikiPageWikiLinkText "Ro5-4864".
- Ro5-4864 atcPrefix "none".
- Ro5-4864 c "16".
- Ro5-4864 casNumber "14439".
- Ro5-4864 chemspiderid "1625".
- Ro5-4864 cl "2".
- Ro5-4864 h "12".
- Ro5-4864 hasPhotoCollection Ro5-4864.
- Ro5-4864 inchi "1".
- Ro5-4864 inchikey "PUMYFTJOWAJIKF-UHFFFAOYAB".
- Ro5-4864 iupacName "7".
- Ro5-4864 legalStatus "Not FDA approved".
- Ro5-4864 molecularWeight "319.185".
- Ro5-4864 n "2".
- Ro5-4864 o "1".
- Ro5-4864 pubchem "1688".
- Ro5-4864 smiles "Clc3cccCc2ccccc2N1C".
- Ro5-4864 stdinchi "1".
- Ro5-4864 stdinchikey "PUMYFTJOWAJIKF-UHFFFAOYSA-N".
- Ro5-4864 verifiedrevid "451564612".
- Ro5-4864 width "150".
- Ro5-4864 wikiPageUsesTemplate Template:Benzodiazepines.
- Ro5-4864 wikiPageUsesTemplate Template:Drugbox.
- Ro5-4864 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Ro5-4864 wikiPageUsesTemplate Template:Npsn.
- Ro5-4864 wikiPageUsesTemplate Template:Reflist.
- Ro5-4864 subject Category:Benzodiazepines.
- Ro5-4864 subject Category:Chloroarenes.
- Ro5-4864 subject Category:Hoffmann-La_Roche.
- Ro5-4864 subject Category:Lactams.
- Ro5-4864 subject Category:TSPO_ligands.
- Ro5-4864 hypernym Drug.
- Ro5-4864 type Article.
- Ro5-4864 type ChemicalSubstance.
- Ro5-4864 type Company.
- Ro5-4864 type Drug.
- Ro5-4864 type Amide.
- Ro5-4864 type Anticonvulsant.
- Ro5-4864 type Article.
- Ro5-4864 type Benzodiazepine.
- Ro5-4864 type Chemical.
- Ro5-4864 type Company.
- Ro5-4864 type Drug.
- Ro5-4864 type Heterocycle.
- Ro5-4864 type Lactam.
- Ro5-4864 type Ligand.
- Ro5-4864 type Modulator.
- Ro5-4864 type Organohalide.
- Ro5-4864 type Organohalide.
- Ro5-4864 type ChemicalObject.
- Ro5-4864 type Thing.
- Ro5-4864 type Q8386.
- Ro5-4864 comment "Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative, the 4'-chloro derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO).".
- Ro5-4864 label "Ro5-4864".
- Ro5-4864 sameAs m.0dllpt_.
- Ro5-4864 sameAs Ro5-4864.
- Ro5-4864 sameAs Ro5-4864.
- Ro5-4864 sameAs Q7339205.
- Ro5-4864 sameAs Q7339205.
- Ro5-4864 wasDerivedFrom Ro5-4864?oldid=673940368.
- Ro5-4864 depiction Ro5-4864.svg.
- Ro5-4864 isPrimaryTopicOf Ro5-4864.
