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- Reticulon abstract "Reticulons (RTNs in vertebrates and reticulon-like proteins or RNTls in other eukaryotes) are a group of evolutionary conservative proteins residing predominantly in endoplasmic reticulum, primarily playing a role in promoting membrane curvature. In addition reticulons may play a role in nuclear pore complex formation, vesicle formation, and other processes yet to be defined. Some studies link RTNs with Alzheimer's disease and amyotrophic lateral sclerosis.All eukaryotes studied so far carry RTN genes in their genomes, the reticulons are absent only in archaea and bacteria. Mammals have four reticulon genes, RTN1, RTN2, RTN3, RTN4.The genes possess a number of exons and introns and are accordingly spliced into many isoforms. C-terminal region of RTNs contains a highly conservative reticulon homology domain (RHD) while other parts of the protein may vary even within a single organism.A peculiar feature of RTN4's isoform RTN4A (Nogo-A) is its ability to inhibit axonal growth. This reticulon subform is curiously absent in fish, a taxon known for the heightened ability of its CNS to regenerate after injury.Transmembrane 33 (TMEM33) exogenously suppresses reticulon 4C function and therefore may play a role in dictating membrane curvature through inhibition of reticulon function.".
- Reticulon wikiPageExternalLink F2.
- Reticulon wikiPageID "21045203".
- Reticulon wikiPageLength "3069".
- Reticulon wikiPageOutDegree "29".
- Reticulon wikiPageRevisionID "661561257".
- Reticulon wikiPageWikiLink Alzheimers_disease.
- Reticulon wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Reticulon wikiPageWikiLink Archaea.
- Reticulon wikiPageWikiLink Axon.
- Reticulon wikiPageWikiLink Bacteria.
- Reticulon wikiPageWikiLink C-terminal.
- Reticulon wikiPageWikiLink C-terminus.
- Reticulon wikiPageWikiLink Category:Proteins.
- Reticulon wikiPageWikiLink Central_nervous_system.
- Reticulon wikiPageWikiLink Conserved_sequence.
- Reticulon wikiPageWikiLink Endoplasmic_reticulum.
- Reticulon wikiPageWikiLink Eukaryote.
- Reticulon wikiPageWikiLink Exon.
- Reticulon wikiPageWikiLink Fish.
- Reticulon wikiPageWikiLink Genome.
- Reticulon wikiPageWikiLink Homology_domain.
- Reticulon wikiPageWikiLink Intron.
- Reticulon wikiPageWikiLink Isoform.
- Reticulon wikiPageWikiLink Lipid_bilayer.
- Reticulon wikiPageWikiLink Mammal.
- Reticulon wikiPageWikiLink Nuclear_pore.
- Reticulon wikiPageWikiLink Nuclear_pore_complex.
- Reticulon wikiPageWikiLink Protein.
- Reticulon wikiPageWikiLink Protein_isoform.
- Reticulon wikiPageWikiLink RTN1.
- Reticulon wikiPageWikiLink RTN2.
- Reticulon wikiPageWikiLink RTN3.
- Reticulon wikiPageWikiLink RTN4.
- Reticulon wikiPageWikiLink Reticulon_4.
- Reticulon wikiPageWikiLink TMEM33.
- Reticulon wikiPageWikiLink Taxon.
- Reticulon wikiPageWikiLink Vertebrate.
- Reticulon wikiPageWikiLink Vesicle_(biology).
- Reticulon wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Reticulon wikiPageWikiLinkText "Reticulon".
- Reticulon wikiPageWikiLinkText "reticulon".
- Reticulon hasPhotoCollection Reticulon.
- Reticulon wikiPageUsesTemplate Template:Protein-stub.
- Reticulon wikiPageUsesTemplate Template:Reflist.
- Reticulon subject Category:Proteins.
- Reticulon hypernym Group.
- Reticulon type Band.
- Reticulon type Biomolecule.
- Reticulon type Biomolecule.
- Reticulon type Nutrient.
- Reticulon comment "Reticulons (RTNs in vertebrates and reticulon-like proteins or RNTls in other eukaryotes) are a group of evolutionary conservative proteins residing predominantly in endoplasmic reticulum, primarily playing a role in promoting membrane curvature. In addition reticulons may play a role in nuclear pore complex formation, vesicle formation, and other processes yet to be defined.".
- Reticulon label "Reticulon".
- Reticulon sameAs m.05b19xg.
- Reticulon sameAs Ретикулон.
- Reticulon sameAs Q4393691.
- Reticulon sameAs Q4393691.
- Reticulon wasDerivedFrom Reticulon?oldid=661561257.
- Reticulon isPrimaryTopicOf Reticulon.