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- ROD-188 abstract "ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche. Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor. ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors.".
- ROD-188 atcPrefix "none".
- ROD-188 iupacName "(5R)-5-{(1R)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}dihydrofuran-2(3H)-one".
- ROD-188 pubchem "9842377".
- ROD-188 thumbnail ROD-188.png?width=300.
- ROD-188 wikiPageID "18455273".
- ROD-188 wikiPageLength "2281".
- ROD-188 wikiPageOutDegree "15".
- ROD-188 wikiPageRevisionID "676759298".
- ROD-188 wikiPageWikiLink Agonist.
- ROD-188 wikiPageWikiLink Antagonist_(pharmacology).
- ROD-188 wikiPageWikiLink Barbiturate.
- ROD-188 wikiPageWikiLink Barbiturates.
- ROD-188 wikiPageWikiLink Benzodiazepine.
- ROD-188 wikiPageWikiLink Benzodiazepines.
- ROD-188 wikiPageWikiLink Bicuculline.
- ROD-188 wikiPageWikiLink Category:GABAA-rho_receptor_negative_allosteric_modulators.
- ROD-188 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- ROD-188 wikiPageWikiLink Category:Lactones.
- ROD-188 wikiPageWikiLink Category:Sedatives.
- ROD-188 wikiPageWikiLink Category:Tetrahydrofurans.
- ROD-188 wikiPageWikiLink Category:Tetrahydroisoquinolines.
- ROD-188 wikiPageWikiLink GABAA_receptor.
- ROD-188 wikiPageWikiLink Muscimol.
- ROD-188 wikiPageWikiLink Receptor_antagonist.
- ROD-188 wikiPageWikiLink Sedative.
- ROD-188 wikiPageWikiLinkText "ROD-188".
- ROD-188 atcPrefix "none".
- ROD-188 c "20".
- ROD-188 h "21".
- ROD-188 hasPhotoCollection ROD-188.
- ROD-188 iupacName "-5".
- ROD-188 legalStatus "Uncontrolled".
- ROD-188 molecularWeight "371.449".
- ROD-188 n "1".
- ROD-188 o "4".
- ROD-188 pubchem "9842377".
- ROD-188 s "1".
- ROD-188 smiles "CC1=CC=CC=C1".
- ROD-188 verifiedrevid "448134172".
- ROD-188 watchedfields "changed".
- ROD-188 wikiPageUsesTemplate Template:Drugbox.
- ROD-188 wikiPageUsesTemplate Template:GABAAR_PAMs.
- ROD-188 wikiPageUsesTemplate Template:GABAergics.
- ROD-188 wikiPageUsesTemplate Template:Hypnotics.
- ROD-188 wikiPageUsesTemplate Template:Reflist.
- ROD-188 wikiPageUsesTemplate Template:Sedative-stub.
- ROD-188 subject Category:GABAA-rho_receptor_negative_allosteric_modulators.
- ROD-188 subject Category:GABAA_receptor_positive_allosteric_modulators.
- ROD-188 subject Category:Lactones.
- ROD-188 subject Category:Sedatives.
- ROD-188 subject Category:Tetrahydrofurans.
- ROD-188 subject Category:Tetrahydroisoquinolines.
- ROD-188 hypernym Drug.
- ROD-188 type Article.
- ROD-188 type ChemicalSubstance.
- ROD-188 type Drug.
- ROD-188 type Agonist.
- ROD-188 type Article.
- ROD-188 type Chemical.
- ROD-188 type Drug.
- ROD-188 type Ester.
- ROD-188 type Ether.
- ROD-188 type Heterocycle.
- ROD-188 type Lactone.
- ROD-188 type ChemicalObject.
- ROD-188 type Thing.
- ROD-188 type Q8386.
- ROD-188 comment "ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche. Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor.".
- ROD-188 label "ROD-188".
- ROD-188 sameAs m.04f32n4.
- ROD-188 sameAs ROD-188.
- ROD-188 sameAs ROD-188.
- ROD-188 sameAs Q7277345.
- ROD-188 sameAs Q7277345.
- ROD-188 wasDerivedFrom ROD-188?oldid=676759298.
- ROD-188 depiction ROD-188.png.
- ROD-188 isPrimaryTopicOf ROD-188.