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- RO5166017 abstract "RO-5166017 is a drug developed by Hoffmann-La Roche which acts as a potent and selective agonist for the trace amine-associated receptor 1, with no significant activity at other targets. This is important for the study of the TAAR1 receptor, as while numerous other compounds are known which act as TAAR1 agonists, such as methamphetamine, MDMA and 3-iodothyronamine, all previously known TAAR1 agonists are either weak and rapidly metabolized (endogenous ligands), or have strong pharmacological activity at other targets (amphetamines, thyronamines), making it very difficult to assess which effects are due to TAAR1 activation. The discovery of RO-5166017 allows purely TAAR1 mediated effects to be studied, and in animal studies it was shown to prevent stress-induced hyperthermia and block dopamine-dependent hyperlocomotion, as well as blocking the hyperactivity which would normally be induced by an NMDA antagonist.".
- RO5166017 iupacName "(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine".
- RO5166017 pubchem "25016538".
- RO5166017 thumbnail RO5166017_structure.png?width=300.
- RO5166017 wikiPageID "35643341".
- RO5166017 wikiPageLength "2579".
- RO5166017 wikiPageOutDegree "9".
- RO5166017 wikiPageRevisionID "639110642".
- RO5166017 wikiPageWikiLink 3-Iodothyronamine.
- RO5166017 wikiPageWikiLink 3-iodothyronamine.
- RO5166017 wikiPageWikiLink Category:TAAR1_agonists.
- RO5166017 wikiPageWikiLink EPPTB.
- RO5166017 wikiPageWikiLink Hoffmann-La_Roche.
- RO5166017 wikiPageWikiLink MDMA.
- RO5166017 wikiPageWikiLink Methamphetamine.
- RO5166017 wikiPageWikiLink NMDA_antagonist.
- RO5166017 wikiPageWikiLink NMDA_receptor_antagonist.
- RO5166017 wikiPageWikiLink O-Phenyl-3-iodotyramine.
- RO5166017 wikiPageWikiLink TAAR1.
- RO5166017 wikiPageWikiLinkText "RO5166017".
- RO5166017 c "12".
- RO5166017 h "17".
- RO5166017 hasPhotoCollection RO5166017.
- RO5166017 iupacName "-4".
- RO5166017 molecularWeight "219.282".
- RO5166017 n "3".
- RO5166017 o "1".
- RO5166017 pubchem "25016538".
- RO5166017 smiles "NC=2OCCCNc1ccccc1".
- RO5166017 width "200".
- RO5166017 wikiPageUsesTemplate Template:Drugbox.
- RO5166017 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- RO5166017 wikiPageUsesTemplate Template:Reflist.
- RO5166017 wikiPageUsesTemplate Template:TAAR_ligands.
- RO5166017 subject Category:TAAR1_agonists.
- RO5166017 hypernym Drug.
- RO5166017 type Article.
- RO5166017 type ChemicalSubstance.
- RO5166017 type Drug.
- RO5166017 type Agonist.
- RO5166017 type Article.
- RO5166017 type Chemical.
- RO5166017 type Drug.
- RO5166017 type ChemicalObject.
- RO5166017 type Thing.
- RO5166017 type Q8386.
- RO5166017 comment "RO-5166017 is a drug developed by Hoffmann-La Roche which acts as a potent and selective agonist for the trace amine-associated receptor 1, with no significant activity at other targets.".
- RO5166017 label "RO5166017".
- RO5166017 sameAs m.0jl0lqd.
- RO5166017 sameAs RO5166017.
- RO5166017 sameAs RO5166017.
- RO5166017 sameAs Q7277303.
- RO5166017 sameAs Q7277303.
- RO5166017 wasDerivedFrom RO5166017?oldid=639110642.
- RO5166017 depiction RO5166017_structure.png.
- RO5166017 isPrimaryTopicOf RO5166017.